Selected Assays
For more information on Selected Assays and links to Abstracts, follow the link provide: Selected Assays
Selected Assays
| PI Name | Title | Target/Phenotype |
|---|---|---|
| WALKER, SUZANNE | Identification of O-Glc NAc Transferase Inhibitors by NTS | O-GlcNAc Transferase |
| MUSTAEV, ARKADY | Development of the HTS Assay for E. Coli RNA Polymerase | RNA polymerase |
| MAYER, THOMAS | Cellular Assay for TNF Alpha Induced NF Kappa B Translocation | human endothelial cell |
| NISWENDER, COLLEEN M | Measurement of GPCR-mediated thallium flux through GIRK Channels | Alpha2C Adrenergic Receptor and (GIRK) channels |
| CHENG, XIAODONG | Oncogene RAS-Based Inhibitors for Pancreatic Cancer | KRAS oncogene |
| ROTHMAN, JAMES E | Aggregation and Clearance of Mutant Huntingtin | huntingtin-polyQ proteins |
| FU, HAIAN | AlphaScreen Technology for High Throughput Screening of 14-3-3/Raf-1 disrupters | 14-3-3/Raf-1 proteins |
| CHIOSIS, GABRIELA | FP Assay for Isolation of Hsp90 Inhibitors | Hsp90 |
| DIAMOND, SCOTT L | Multiplexed HTS of Serine and Cysteine Proteases | Factors IXa, Xla, Xa; Serine proteases C1s, C1r, Factor D; Cathespins B, S, G |
| MAYER, THOMAS | Cellular Assay for TNF Alpha Induced E-Selectin Expression | endothelial cell activation (P) |
| LAZO, JOHN S | Chemical Complementation Assay for MKP-1 | MKP-1 |
| GOLDFARB, DAVID S | Yeast Lifespan Chemical Screening | Aging and Lifespan (P) |
| CHEN, BENJAMIN P | Screening of DNA-PKcs Autophosphorylation Blockers via Cell-Based Approach | DNA-Dependent Protein Kinase Catalytic Subunit |
| EDWARDS, BRUCE | Assay for Formylpeptide Receptor Family Ligands | Formylpeptide Receptor |
| SANNA, M GERMANA | MLSCN HTS Assays R03 - S1P1 | S1P1 |
| ROTHMAN, JAMES E | Regulation of Neurotransmitter Transporter Recycling | Neurotransmitter Transporters: DAT, |
| MAYER, THOMAS | Cellular Assay for the Presentation of the Adhesion Molecule VCAM1 on the surface of HUVEC cells | Cell Surface Expression of VCAM1 (P) |
| PAUMET, FABIENNE | Unraveling the Molecular Mechanisms of Phagocytosis | Phagocytosis (P) |
| CHIOSIS, GABRIELA | Isolation of Inhibitors of Her-Kinase Expression | Her-Kinase Experssion (P) |
| WILLIAMS, DAVID L | HTS for Inhibitors of Schistosoma Mansoni Peroxiredoxins | Peroxiredoxins |
| WILKINSON, KEITH D | HTS Assay for Inhibitors of BAP1, a BRCA1 Associated Deubiquitinating Enzyme | BAP1 |
| ZHOU, MING | Small-Molecule Modulators of a Family of Voltage-Dependent Potassium Channel | KvBeta |
| WHITE, E. LUCILE | High Throughput Screen for Mycobacterium Tuberculosis Pantothenate Synthetase | Pantothenate Synthetase |
| APPEL, BRUCE | A Screen For Drugs That Promote Oligodendrocyte Formation in Zebrafish | Oligodendrocyte Formation (P) |
| TEITLER, MILT | Human 5HT 1E Serotonin Receptor Drug Development | 5HT 1E Serotonin Receptor |
| LAZO, JOHN S | Chemical Complementation Assay for MKP-3 | MKP-3 |
| LAZO, JOHN S | In Vitro High Throughput Screening Assay for MKP-1 | MKP-1 |
| LAZO, JOHN S | In Vitro High Throughput Screening Assay for MKP-3 | MKP-3 |
| CONN, P JEFFREY | Discovery of novel allosteric modulators of the M1 muscarinic receptor | M1 Muscarinic Receptor |
| HARSAY, EDINA | Chemical Genetics Screens to Identify Modulators of Post-Golgi Transport | Post-Golgi Transport (P) |
| KURET, JEFF A | Ligands for premortem diagnosis and treatment of Alzheimer's disease | Tau protein |
| LEWIS, KIM A. | A Screen for Novel Antimicrobials | Prodrug Converting Enzymes |
| LI, XIAOLING | High Throughput Screening of Select Orphan Nuclear Receptors | SF-1, RORa, and RORb |
| MCHENRY, CHARLES S | Conducting a HTS against a Multi-protein DNA Replication System | DNA replication apparatus |
| Mercola, Mark | Screening for Compounds That Modulate Insulin Promoter Activity in TRM-67 Cells | Insulin Expression (P) |
| Mercola, Mark | Screening for Compounds That Modules Insulin Promoter Activity in MIN-6 Cells | Insulin Expression (P) |
| MILLAN, JOSE LUIS | Pharmacological inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) | TNAP |
| Mustelin, Tomas M | HTS for LYP inhibitors-an autoimmunity target | LYP |
| Mustelin, Tomas M | HTS for HePTP Inhibitors-a leukemia target | HePTP |
| NISWENDER, COLLEEN M | Discovery of novel allosteric agonists of the M4 muscarinic receptor | M4 Muscarinic Recpetor |
| PARNIAK, MICHAEL A | HTS assays for inhibitors of HIV RNase H | HIV RNase H |
| PASQUALE, ELENA B | EphA4 Receptor Antagonists for Nervous System Repair | EphA4 |
| PAVITT, GRAHAM D | High-throughput screen for a therapeutic agent for elF2B-related disorders | Mutant elF2B (P) |
| PIAZZA, GARY A | Identification of Molecular Probes that Reverse MRP-Mediated Drug Resistance | Multidrug Resistance Protein (MRP) |
| PROSSNITZ, ERIC R | MLSCN Assay for Ligands of GRP30 and Classical Estrogen Receptors | GRP30 |
| PROSSNITZ, ERIC R | MLSCN Assay for Inhibitors of Arrestin-GPR Interactions | Arrestin-GPCR Interaction |
| REED, JOHN C | Chemical Inhibitors of anti-apoptotic protein Bfl-1 | Bfl-1 |
| REED, JOHN C | Chemical inhibitors of antigen receptor-induced NF-?Beta activation | NF-kappaB Expression (P) |
| RUBINSTEIN, AMY L | Zebrafish Lipid Metabolism Assay | Lipid Absorption and Processing (P) |
| SHARLOW, ELIZABETH R | Fluroscence polarization assay for PLK1 inhibitors | PLK1 |
| Sklar, Larry A | MLSCN Assay for Allosteric Ligands for the VLA-4 Integrin | VLA-4 |
| SKOWYRA, DOROTA | ATP Hydrolysis-dependent disassembly of the 26S proteosome as an HTS assay for flow cytometry | 26S Proteasome (P) |
| STRONGIN, ALEX Y | Inhibitors of the NS3 Proteinase of West Nile and Dengue Viruses | NS3 Proteinase |
| STURGESS, MICHAEL A | Development of a HTS assay for Inhibitors of bacterial DnaK | DnaK |
| WATTS, VAL J | Allosteric Modulators of D1 Receptors | D1 Receptor |
| Yi, Fang | Identifying novel Hsp90 Inhibitors by disrupting its cochaperone interaction using an AlphaScreen based high throughput screening assay | Hsp90/HOP |
| ZHENG, WEI | HTS for Identification of Glucocerebrosidase Activators and Inhibitors as Pharmacological Chaperones for the Potential Treatment of Gaucher Disease | Glucocerebrosidase |
| WILLIAMSON, JAMES R | High Throughput Screen for Inhibitors of the HIV Rev-RRE RNA Interaction | HIV Rev-RRE RNA complex |
| LEYH, THOMAS S. | Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae | mevalonate kinase, diphosophomevalonate kinase decarboxylase, phosphomevalonate kinase |
| THOMPSON, TODD ANTHONY | Activators of Prostate Cell Differentiation | Prostate Cell Differentiation (P) |
| KELLY, JEFFERY W | High Throughput Screening for Protein Misfolding Disease Therapeutics | Glucocerebrosidase |
| MCPIKE, MARK PATRICK | Rapid Mix and Measure HTS Assays for Anti-NCp7 Drug Discovery | NCp7-RNA Interactions |
| PELLECCHIA, MAURIZIO | Chemical Tools to Investigate the Protein Folding/Degradation Machinery | HSP70 |
| DESAI, SANJAY A | High-Throughput Screen for Antagonists of the Plasmodial Surface Anion Channel (PSAC) | Plasmodial Surface Anion Channel (PSAC) |
| YAFFE, MICHAEL B | High Throughput Screening for Inhibitors of the Polo Box Domain of Human Polo-Like kinase-1 | Plk1 |
| HOFFMANN, MICHAEL | Targeting a Protein Interaction Site on Smad Transcription Factors | Smad Transciption Factors |
| FIELDS, GREGG B | ADAMTS/MMP Drug Development | MMP-13, ADAMTS-4 |
| STRONGIN, ALEX Y | Screening Chemicals to Suppress MT1-MMP Synthesis in Cancer | MT1-MMP |
| WELLS, JAMES A | Inhibitors of Caspase-1 and Caspase-7 | Caspase-1, Caspase-7 |
| GRESHAM, HATTIE D. | Small Molecule Inhibition of Staphylococcus Aureus Virulence | S. Aureus pheromone-dependent activation of RNAIII promoter (P) |
| KATZENELLENBOGEN, JOHN A. | Screen for Coactivator Binding Inhibitors to Block Estrogen Action | Estrogen Receptor-Activated Genes (P) |
| HAMMOCK, BRUCE D | Novel sEH Inhibitors for the Therapeutic Treatment of Hypertension and Inflammation | Soluble Epoxide Hydrolase |
| AULD, DOUGLAS S | Identification of lkappaBalpha Stabilizers in a Human Lymphoma Cell Line Using A Two-Color Luciferase Based Cell Sensor Assay | NF-kappaB (P) |
| BRISSON, MARNI J | Homogeneous Flourescence Intensity High Throughput Assay for Cdc25B Phosphatase Inhibitors | Cdc25B |
| SHOICHET, BRIAN K. | Promiscuous and Specific Inhibitors of B-lactamase | B-lactamase |
| MARTINEZ, ELISABETH D | High Throughput Screens for Epigenetic Modulators | Epigenetic Modulators & Pathways |
| NICHOLSON, BENJAMIN | Identification of Compounds that Modulate Human Deubiquitinase Function | USP2a |
| SUN, YI | Synthetic Lethal Screen for Compounds to Kill Cancer Cells with p53 Mutation | Mutant p53-Containing Cells (P) |
| NIRENBERG, MARSHALL WARREN | Molecules that Enhance CREB Activity | CREB |
| SKLAR, LARRY A. | HTS for BCI-2 Family Multiplex | BCl-2 Family Proteins |
| Seidah, Nabil G. | High Throughput Screens for Targets of the Proprotein Converstases Furin, PC5, SKI-1 and PCSK9 Using Cell-based Assays | Furin |
| KUHN, PETER | EphB4-Ephrin-B2 Antagonists for Angiogenesis and Carcinogenesis Inhibition | EphB4-Ephrin-B2 |
| FRANK, DAVID A | Modulators of STAT transcription factors for the targeted therapy of cancer | STAT1, STAT3 and STAT5 pathways (P) |
| GRIFFIN, PATRICK R. | HTRF screen for identifying SRC-1 selective agonists of PPARgamma | PPARgamma |
| GU, HOWARD H | High Throughput Screening for Cocaine Antagonists | DAT |
| REED, JOHN C | High Throughput Screening Assay for Hsp70 Inhibitors | Hsp70 |
| MERCOLA, MARK | Screen for Compounds that Promote Cardiomyocyte Cell Cycle Entry | Cell Cycle Entry of Cardiomyocytes (P) |
| ROGERS, JACK T | MLSCN Screen of the Amyloid precursor protein 5'untranslated region | Amyloid precursor protein (APP) 5' UTR |
| DE FIGUEIREDO, PAUL | Drug Discovery for Bone Marrow Failure Diseases | S. Cerevisiae Model of Schwachman-Diamond Syndrome (P) |
| LIOU, HSIOU-CHI | Development of Screening Assays for NF-KB-Rel Inhibitors | NF-kappaB/Rel |
| QU, ZHICAN | Cell-Based Screening for Anti-Angiogenic Agents | Angiogenesis (P) |
| GERSHENGORN, MARVIN C | Ligand discovery for thyroid-stimulating hormone receptor (TSHR) by virtual and high throughput screening | thyroid-stimulating hormone receptor (TSHR) |
| KOLE, RYSZARD | Modulation of Alternative Splicing by HTS Identified Compounds | Human Beta-globin Intron 2 with a Thalassemic Splicing Mutation (P) |
| LEWIS, KIM | Screening C. Albicans Biofilms for Lethal Potentiators of Miconazole | Lethal Potentiators of Miconazole (P) |
| NATARAJAN, AMARNATH | HTS to Identify Small Molecule Inhibitors of Phospho-Specific Protein-Protein Interactions | BRCA1 |
| HASELBECK, ROBERT JOHN | Identification of Target-Specific | Bacillus anthracis |
| WANDINGER-NESS, ANGELA | HTS to Identify Specific Small Molecule Inhibitors and Activators of Ras and Ras-Related GTPases | Ras |
| YUAN, JUNYING | A High Throughput Screen for Inhibitors of a Novel Necrotic Cell Death Pathway | Necroptosis (P) |
| MARSHALL, WALLACE | Small Molecule Inhibitors of Cilia | Cilia (P) |
| TOBIAS, PETER S | High Throughput Screening for Toll-Like Receptors | Toll-like receptors (TLR) |
| SEVERSON, WILLIAM E | A Cell Based HTS Approach for the Discovery of New Inhibitors of the H5N1 Virus | H5N1 |
| LI, QIANJUN | A HTS Assay for Identifying Anti-Viral Drugs Against Arbovirus Infections | Arbovirus |
| NUNNARI, JODI M | Chemical Genetic Screens for Mitochondrial Division and Fusion Inhibitors | Mitochondrial Division and Fusion |
| REED, JOHN C | Chemical Antagonists of IAP-Family Anti-Apoptotic Proteins | SMAC/Inhibitor of apoptosis proteins (IAPs) binding |
| ROZANOV, DMITRI | Screening for Chemicals that Potentiate TRAIL-Induced Apoptosis of Cancer Cells | TRAIL-mediated apoptosis (P) |
| PLEMPER, RICHARD K. | High Throughput Screening-Based Identification of Measles Virus Probes | Measles Virus (P) |
| PELLETIER, JERRY | Screening for Small Molecule Inhibitors of Eukaryotic Translation Initiation | eIF4F/elF4E and eIF4F/elF4G |
| HOLMAN, THEODORE R | High Throughput and Virtual Screening for Human 12-LO, 15-LO-1, and 15-LO-2 Inhibitors | Human Lipoxygenase (hLo) Isozymes |
| WANG, QIMING JANE | IMAP-based fluorescent polarization assay for high throughput screening of protein kinase D inhibitors | protein kinase D (PKD) |
| MCNEIL, MICHAEL R | HTS Screen of TB RmlC & RmlD dTDP-Rhamnose Formation Enzymes | RmlC, RmID |
| LEISSRING, MALCOLM A | HTS for Modulators of Beta-Amyloid Catabolism by Insulin-Degrading Enzyme | Insulin Degrading Enzyme (IDE) |
| GLASS, JONATHAN DAVID | Discovering Calpain Inhibitors for Neurological Diseases | Calpain |
| PELLECCHIA, MAURIZIO | Novel Chemotypes Against Influenza A Virus | M2 Proton Channel |
| GRIMALDI, MAURIZIO | An HTS Assay Based on Neuronal Human Cells to Identify Small Molecule Activators | NF-kappaB Expression (P) |
| RON, DAVID | Screening for Inhibitors of the Integrated Stress Response | Integrated Stress Response (ISR) PERK Kinase Pathway |
| STAUFFACHER, CYNTHIA V | Scaffolds for Synthesis of Probes Directed Against Class II HMG-CoA Reductases | Class II HMG-CoA Reductase |
| MCDONOUGH, PATRICK M | High Throughput Imaging Assay for Beta-Catenin | Beta-Catenin Distribution (P) |
| MILLAN, JOSE LUIS | Activators of the Pyrophosphatase Activity of Alkaline Phosphatase | Tissue-Non-Specific Alkaline Phosphatase (TNAP) |
| COOMBS, GARY (c) | The Role of Wnts in Stem Cell | Wnt Signaling Pathway (P) |
| REED, JOHN C | Chemical Inhibitors of ER Stress | ER Stress Signaling Pathway (P) |
| SHOICHET, BRIAN K. | Promiscuous and Specific Inhibitors of Cruzain | Cruzain |
| BUGGE, THOMAS H | Quantitative High Throughput Screening for Anthrax Toxin Inhibitors | Anthrax Toxin Intoxication (P) |
| ZHENG, WEI | HTS for Identification of Inhibitors against the ERK Signaling Pathway using a Homogenous cell based assay | ERK signaling pathway (P) |
| ZHENG, WEI | HTS for Identifying the Cell-Membrane Permeable IMPase Inhibitors. | Inositol Monophosphatase |
| BALLATORE, CARLO | High Throughput Screening for Small Molecule Inhibitors of Heparin-Induced Tau Fi | Heparin-induced tau K18PL protein fibrilization |
| BURKART, MICHAEL D | A qHTS FRET-Quench Assay for 4?-Phosphopantethienyltransferases | Bacterial phosphopantetheinyl transferase (PPTase) |
| BUSHWELLWE, JOHN H | Screening for Inhibitors of Runx and CBFb Translocation Products in Leukemia | Runx1:CBFbeta, Runx1:CBFbeta-SMMHC interaction |
| COLLER, BARRY S | High Throughput Screening for Novel Inhibitors of Platelet Integrin alphallb-beta3 | Binding of human platelets to integrin alphallb-beta3 |
| DAY, BILLY W | HTS Assay for Microtubule Stabilizers | Microtubules |
| FREEZE, HUDSON H | Therapeutic Inhibitors of Phosphomannose Isomerase | Phosphomannose isomerase (PMI) |
| GARDINER, DONALD L | High Throughput Screening of Plasmodium Falciparum Aminopeptidases | Plasmodium falciparum aminopeptidases |
| HELLER, STEFAN | Identification of Modulators of the TRPML3 and TRPN1 ion Channels | TRPML3, TRPN1 ion channels |
| LARSON, RICHARD S | Multiplex Screening for ABC Transporter Inhibitors | ABCB1, ABCC1, ABCG2 transporters |
| LIU, PU PAUL | High Throughput Screening for Compounds Blocking Interaction between CBFb-SMMHC a | CBFbeta:SMMHC, RUNX1 interaction |
| MATTS, ROBERT L | High Throughput Screen for Hsp90 Inibitors | Hsp90 |
| MORRIS, JAMES CULVIN | Identification of Inhibitors of Trypanosoma Brucei | T. brucei hexokinase (TbHK) |
| PASSER, BRENT J | A High Throughput Screen to Identify Small Molecule Compounds that Augment the Spread of the oncolytic HSV-based G47? virus | oncolytic activity of HSV-1, G47? |
| SEVERSON, WILLIAM | A Cell Based HTS Approach for the Discovery of New Inhibitors of RSV | Respiratory Syncytial Virus (RSV) |
| SMITH, SUSAN M.E. | HTS to Find Inhibitors of p47phox, a Regulatory Protein of Noxes | NADPH oxidases (Nox1 and Nox2) |
| SMITHGALL, THOMAS | Targeting HIV-1 Nef with Small Molecules | HIV-1 Nef |
| STOCKWELL, BRENT R | Luciferase Screen for MDM2 E3 Ligase Inhibitors | MDM2 E3 ligase |
| YIN, XIAO-MING | High Content Cell Based Screening for Modulators of Autophagy | Autophagy pathway |
| AYAD, NAGI G | Small-molecule Inhibitors of Wee1 Degradation and Mitotic Entry | degradation of Wee1 protein |
| BROWN, STEVEN J | Development of a High Throughput Screening Galanin 3 Receptor Assay | Galanin 3 Receptor |
| DAY, BILLY W | High Throughput/Content Screens for Dynein Inhibitors | dynein-dependent nuclear translocation of glucocorticoid receptor |
| DELISA, MATTHEW P | A cell-based screen for inhibitors of intracellular Abeta aggregation | intracellular Abeta aggregation |
| DELPIRE, ERIC J | Modulators of CL-dependent Transport Processes | cation-chloride co-transporters NKCC1 and KCC2 |
| DENTON, JEROD S | Identification of novel modulators of ROMK K+ channel activity | Renal Outer Medullary 1C (ROMK1) potassium channel |
| DESHMUKH, MOHANISH | Chemical Probes for Uncovering Differential Regulators o | caspase activation in dividing and postmitotic cells |
| DEVI, LAKSHMI A | Assay to Screen Ligands:Activate Opioid Receptor | opioid receptor heterodimers |
| DINGLEDINE, RAYMOND J | Prostanoid modulators that reduce brain injury and inflammation after seizures | prostanoid receptors EP2 and DP2 |
| GUPTA, VINEET | Developing HTS Assays for Discovery of Small Molecule Regulators of Integrins | CD11b/CD18 heterodimer integrin in leukocytes |
| Guy, Rodney K. | Novel Inhibitors of Nuclear Receptor Function | interaction between nuclear receptors and co-regulators |
| JARDETZKY, THEODORE S | HTS for Small Molecule Modulators of EB Virus Protein-Protein Interactions | interaction between Epstein-Barr virus proteins gp45 and gH/gL |
| LU, YILING | Tissue Lysate Arrays for Molecular Screening | tissue lysate |
| MCNEIL, MICHAEL R | Glucosamine-1-phosphate and serine acetylases: HTS assays and configurations | two acetyl transferases: glucosamine-1-phosphate acetyl transferase (GAT) and serine acetyl transferase (SAT) |
| NEUBIG, RICHARD R | Multiplexed flow cytometry screens for RGS inhibitors | G? binding to RGS 4, 6, 7, 8, and 9 |
| NIKOLOVSKA-COLESKA, ZANETA | Discovery and characterization of novel small molecule inhibitors of Mcl-1 | Myeloid cell leukemia-1 (Mcl-1) protein |
| NISWENDER, COLLEEN M | Assay for HTS of Gi/Go-linked GPCRs: mGluR7 as the Prototype | mGluR7 recptor |
| SIDEROVSKI, DAVID P. | Real-Time Fluorescence Assay:RGS Domain GAP Activity | RGS protein GAP activity |
| WAHLESTEDT, CLAES ROBERT | Assay Development Relating to the HTS of the Neuropeptide Y-Y2 Receptor | neuropeptide Y (NPY) Y2- receptor |
| WALDMAN, TODD A | Cell-Based Screens for Cancer:Targeting PTEN | tumor suppressor PTEN-deficient human cancer cells |
| WALDMAN, TODD A | Isogenic Cell-Based Screen:Cancer-Targeting Catenin | b-catenin oncogene pathway in human cancer cells |
| WEISS, ERIC LYLE | Development of a robust high throughput assay for the discovery of RAM network in | RAM (Regulation of Ace2 and Morphogenesis) network signaling pathway in yeast |
| WILSON, ROBERT B | Friedreich Ataxia High Throughput Drug Screening Assays | mitochondrial frataxin activity in primary Friedreich’s ataxia (FRDA) fibroblasts and a yeast model |
| XIE, XINMIN SIMON | HTS Assay for Ca 3 T-type Channels Using FLIPR | three subtypes of Cav3 T-type channels |
| ZHU, MICHAEL X | High throughput screening of ligands of TRP channels | TRPC ion channels |
