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A probe project executed by the Scripps Research Institute (TSRI), a funded center of the NIH Common Fund Molecular Libraries and Imaging Program (MLP), has become the program’s first to yield a drug candidate tested in humans. The initial probe compound resulting from the MLP efforts, an agonist of the sphingosine-1-phosphate receptor 1 (S1P1) and related molecules, was further developed outside of the MLP by TSRI and Receptos Inc., eventually resulting in administration to the first human subject in an FDA approved Phase 1 clinical safety study being undertaken by Receptos Inc. The clinical study has been initiated as a potential treatment for multiple sclerosis. More …

**New Opportunity to Access ML Resources**

NIH is soliciting projects to directly access medicinal chemistry resources provided by the MLPCN via the Fast-Track mechanism.  NIH investigator-initiated and institute-sponsored projects and activities that are currently active but lack sufficient medicinal chemistry support are eligible to apply.  More …

Overview

The Molecular Libraries Program (MLP; an NIH Roadmap Initiative) aims to enhance chemical biology efforts through High Throughput Screening (HTS) to obtain small molecule probes effective at modulating a given biological process or disease state.  More …

Molecular Libraries Probe Production Centers (MLPCN)

The flagship of the MLP is the Molecular Libraries Probe Production Centers, a network of national laboratories, whose aim is generate novel small molecule probes by performing HTS, secondary screens and medicinal chemistry. The assays for these probes are sourced from the scientific community.

Accessing the MLPCN
The scientific community can access the resources of the MLPCN through various funding initiatives that are part of the MLP.  More …
Small Molecule Probes
The small molecule probes already identified in the pilot phase of the MLP can be found here.
Access To Results
The MLPCN (as well as the pilot phase initiative) is a public resource and as such all the biological data generated as well as the identity of the small molecules (300,000+ compounds) is in the public domain.  More …
The Centers
Find details about the MLPCN centers here.

Other Supporting MLP Initiatives

The Molecular Libraries Program has other initiatives intended to further develop chemical biology. These initiatives are focused on technology development and contain future funding information.  More …

Further Development of Small Molecule Probes

NIH has many pre-existing and new efforts to further develop small molecule probes resulting from the MLPCN effort. More …

Frequently Asked Questions

More details on the Molecular Libraries program including a FAQ are available on this website and can be accessed using the menus on top.