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MLPCN


Probe Production Phase - MLPCN

The Molecular Libraries Program (MLP) is a full-scale production program emphasizing the generation of high quality probes and biological-chemical data for high-value targets. The long-term goal of the MLP is to develop new small molecule probes that will be used as research tools with the expectation that increased knowledge and wider understanding of probe chemistry will accelerate the development of new therapeutics. These research tools may aid in the identification and analysis of protein function, signaling and metabolic pathways, and cellular function important to the maintenance of human health.

As a central component of the MLP, the Molecular Libraries Probe Production centers Network (MLPCN) is a collaborative research network with complementary abilities that will enable screening of diverse types of assays and generation of chemical probes to address a wide range of biological opportunities. Like the MLSCN, the MLPCN offers HTS and probe development resources to the community under its Data Sharing and Intellectual Property (IP) policy.

In contrast to the ten similarly structured centers of the pilot phase, the MLPCN will be composed of three different types of centers (Comprehensive Centers, Specialized Screening Centers, Specialized Chemistry Centers) working together as a network to provide improved handling of the diverse classes of investigator-submitted assays as well as enhanced chemistry support for the large number of active compounds identified by the screening centers.

(See MLSCN for more information on the pilot program).

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