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MLPCN Centers

As a central component of the Molecular Libraries Program, the Molecular Libraries Probe Production Centers Network (MLPCN) is a collaborative research network with complementary abilities that will enable generation of effective and useful small molecule chemical probes for the entire biomedical research community. The MLPCN offers HTS and probe development resources to the community under its Data Sharing and Intellectual Property (IP) policy.

The MLPCN is composed of three different types of centers:

  • Comprehensive Centers: Provide all three services: assay, cheminformatics/informatics, and medicinal chemistry within a single site. Broad, Burnham, NCGC, and Scripps are comprehensive centers.
  • Specialized Screening Centers: Handle specialized types of assays including handling assay informatics. Johns Hopkins, Southern Research Institute, and UNM are specialized screening centers.
  • Specialized Chemistry Centers: Focus on providing medicinal chemistry and cheminformatics support for performing structure-activity relationships that is typically needed to produce useful chemical probes from screening hits. These are located at Kansas and Vanderbilt.

A network environment provides improved handling of the diverse classes of outside investigator-submitted assays as well as enhanced chemistry and informatics/cheminformatics support for performing structure-activity analysis and medicinal chemistry required to convert the large number of active compounds identified by HTS screening into useful probes.

Specific Center Capabilities

Detailed listing of the specific capabilities of each center and other details can be found here.

Pilot Program

Details about the pilot phase of the Molecular Libraries Centers Network can be found here.