Molecular Libraries Small Molecule Repository

The Molecular Libraries Small Molecule Repository (MLSMR) is designed to identify, acquire, maintain, and distribute to the Molecular Libraries Screening Centers Network (MLSCN)an eventual collection of approximately 500,000 chemically diverse compounds with known or unknown biological activities for use in high-throughput screening (HTS) of a diverse set of biological assays submitted by the research community and implemented within the centers. It is anticipated that a subset of the screening “hits” that are generated will be further developed by the MLSCN into optimized chemical analogs that can be used by the scientific community as bioactive Probe Guidelines to study molecular targets and cellular pathways, and potentially as starting points for therapeutics development outside of the MLSCN. The chemical structures of the compounds in the repository, along with the associated screening data obtained from the MLSCN, will be shared with the public through PubChem.