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Compound Submission to the SMR

The MLSCN Pilot Phase ended in June 2008.

Compound submission to the MLSMR will continue.

Please the NIH Notice for MLSMR Compound Solicitation:

NIH invites investigators in the public and private sectors to submit compounds to the NIH Molecular Libraries Small Molecule Repository (MLSMR) to be used for high throughput biological screening (HTS) by the Molecular Libraries Screening Centers Network (MLSCN).

Goals of Compound Solicitation

  1. Expansion of the MLSMR compound collection with structurally diverse compounds;
  2. Screening of these compounds against a variety of biochemical and cell-based assays by the MLSCN to identify and develop probes of biological function;
  3. Providing compound suppliers with information on the biological activities of their compounds; and
  4. Making information about the chemical structures and biological activities of the compounds freely accessible through PubChem.


By submitting small samples of compounds to the MLSMR, contributing investigators may benefit in some important ways:

  1. The MLSCN will be implementing an unprecedented number and variety of biological screening assays. While chemists frequently collaborate to obtain screening data on their compounds, providing samples to the MLSCN will greatly increase the chances of finding interesting new bioactivities.
  2. HTS hits on contributed compounds have the potential to stimulate new research programs to further develop potent, selective, and broadly useful modulators of novel biological targets.
  3. Interdisciplinary contacts will be facilitated by PubChem, which will identify the source of each compound and each assay. PubChem will be universally accessible, and the HTS data will be subject to extensive data mining. This resource may inspire biologists and chemists to develop collaborative relationships when interesting patterns of bioactivity are observed, leading to new research projects and new opportunities for grant funding.
  4. The wide variety of HTS assays implemented in the MLSCN may provide opportunities to identify new uses for well-known, bioactive compounds, including approved drugs.
  5. The materials contributed to the MLSMR will contribute to a thorough and unprecedented investigation of gene product function.