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Molecular Libraries Probe Production Centers Network (MLPCN) Symposium

July 12, 2011
8am – 3:30pm
NIH Campus, Building 45, Natcher Auditorium
45 Center Drive, Bethesda, MD 20892

This symposium will showcase the accomplishments of the Molecular Libraries Probe Production Centers Network (MLPCN). The Principal Investigators of the network centers will present exciting chemical probes produced by their centers, along with the technology that makes the discovery and development process possible. Presentations will be given by comprehensive centers, specialized screening centers, and specialized chemistry centers. The symposium will conclude with a discussion on the MLPCN and its relationship to the outside scientific community and the NIH.

Dr. Stuart Schreiber
Broad Institute Comprehensive Screening Center

Dr. Min Li
Johns Hopkins Ion Channel Center

Dr. Jeffrey Aube
Kansas Specialized Chemistry Center

Dr. John Reed
Sanford-Burnham Center for Chemical Genomics

Lucile White
Southern Research Specialized Biocontainment Screening Center

Dr. Craig Lindsley
Vanderbilt Specialized Chemistry Center for Accelerated Probe Development

Dr. Hugh Rosen
The Scripps Research Institute Molecular Screening Center

Dr. Larry Sklar
University of New Mexico Center for Molecular Discovery

Dr. Christopher Austin
NIH Chemical Genomics Center

Allison Mandich

Molecular Libraries Protein-Protein Interaction Workshop

October 28 – 29, 2010
DoubleTree Hotel
Bethesda, MD

Registration is now open: click here to register online. (Meeting registration is free.)

The NIH Molecular Libraries Program (MLP; an NIH Common Fund Initiative, invites you to participate in an upcoming Workshop on Protein-Protein Interactions (PPIs) as targets for molecular screening and therapeutics development. The meeting will convene scientists and NIH program directors to address current perspectives and future directions in PPI research. Agenda is listed below (more information in the web page). Participatory breakout sessions and group discussions will address the potential of PPIs as molecular targets and how the NIH Molecular Libraries program may help to advance this field. The workshop presents an opportunity for the PPI field to provide substantive input that may influence the development of future NIH programs in this area. We look forward to your participation to help identify research gaps and opportunities in PPI research as well as general impediments to progress in this area.

Aims of the Workshop and Expected Outcomes
The workshop aims to uncover new ways of addressing the modulation of PPIs. Speakers and breakout discussion sessions are expected to address the following key questions and topics.

  • A. PPIs as targets for molecular screening and therapeutics development:
    i. New chemical/compound library approaches to the assays and techniques.
    ii. How can structural biology, computational biology and bioinformatics be used systematically to analyze the druggability of PPI surfaces?
    iii. What makes a good surface pair versus a bad surface pair for discovery of PPI inhibitors in standard small molecule collections like the Molecular Libraries Small Molecules Repository?
  • B. In the next 2-3 years: -how can the ML program influence the modulation of PPIs?
    i. How can the above information be used to select high priority PPI families that are suitable as targets for the Molecular Libraries Production Centers Network (MLPCN)? e.g. PDZ domains, heterotypic versus homotypic partners, other PPI family classes.
    ii. Recruiting new PPI-related assays.
    iii. New detection platforms.
  • C. In the longer term: -what new areas of PPIs research should NIH focus on? Can this lead to a new NIH initiative?
    i. What basic science areas applicable to PPIs would have multi-agency interest/impact?
    ii. Presentations and Breakout sessions
    iii. One Poster Session
  • Invited Speakers include:

  • Ruben Abagyan, UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences
  • Michelle Arkin, University of California, San Francisco
  • Paramjit Arora, New York University
  • David Fry, Hoffmann-La Roche Inc
  • Haian Fu, Emory University
  • Sam Gellman, University of Wisconsin, Madison
  • Jonathan Javitch, Columbia
  • René M. Lemieux, Boehringer Ingelheim Pharmaceuticals, Inc.
  • Donald P. McDonnell, Duke University Medical Center
  • Andrew M Petros, Ph.D., Abbott
  • Gregory L. Verdine, Harvard University
  • Adrian Whitty, Boston University
  • Discovery of Molecular Probes

    November 16, 2010, 6:30 – 9:00pm
    At the Society for Neuroscience Annual Meeting
    San Diego Convention Center, Rm 10
    San Diego, CA

    Registration is now open: click here to register online. (Meeting registration is free.)

    Interdisciplinary research in chemical biology and high throughput screening (HTS) has enabled discovery of novel molecular probes for neurobiological studies and drug discovery in academic settings. This has created a new opportunity for neuroscientists to perturb and measure neural signaling, elucidate pathophysiological mechanisms, and discover small molecule therapeutics. This meeting provides a venu for eminent investigators to discuss their recent research advancements in this area. The meeting highlights how interdisciplinary studies in chemical biology open up new approaches to unraveling the molecular basis of neural signaling and CNS disorders, including discovery of novel chemical modulators of synaptic transmission and membrane excitability, development of imaging probes, validation of therapeutic approaches, dissection of mechanisms underlying neural signaling pathways, and exploration of chemical diversity to generate high precision probes of receptor structure and function. The meeting also highlights how research in chemical biology can shed new light on difficult problems that are recalcitrant to conventional biological approaches.

  • Dr. Roger Y. Tsien (Department of Chemistry and Biochemistry, University of California, San Diego)
    Title: Building vs. Breeding Neurobiological Probes
  • Dr. P. Jeffrey Conn (Department of Pharmacology, Vanderbilt University Medical Center)
    Title: Discovery of Allosteric Modulators of GPCRs for Treatment of CNS Disorders.
  • Past Meetings

    Chemical Probes for Neuroscience Research and Drug Discovery

    October 16, 2009
    At the Society for Neuroscience Annual Meeting
    Chicago, IL

    Registration is now open: click here to register online. (Meeting registration is free.)

    Discovery of Disease Targets and Chemical Probes

  • G protein-Independent Receptor Signaling: New Biological and Therapeutic Targets?; Marc G. Caron, Duke University
  • Chemical Probes of Wnt/GSK-3 Signaling in the CNS; Stephen J. Haggarty; Broad Institute
  • Allosteric modulators of GPCRs as a novel approach to treatment of CNS disorders; P. Jeffrey Conn; Vanderbilt University
  • Johns Hopkins Ion Channel Center – When vast chemical diversity meets ion channel targets; Min Li, Johns Hopkins University School of Medicine
  • A Chemical Biology Approach Identifies Modulators of ER Stress: Implications for the Treatment of Neurodegenerative Diseases; Nicholas Cosford, Burnham Institute for Medical Research
  • Creating Zinc Monkey Wrenches: Disease Modification through Epigenetics; Alan P. Kozikowski, University of Illinois Chicago
  • Modulating Beta-Secretase Activity, Evolution from Inhibitors to Drugs; Jordan J. Tang, University of Oklahoma Health Science Center
  • Innovative Molecular Probes for Neuroscience Research

  • Probing Neuroreceptors and Ion Channels with Unnatural Amino Acids; Dennis A. Dougherty, California Institute of Technology
  • Rewiring GPCR Signals in vivo with RASSLs; Bruce R. Conklin, University of California, San Francisco
  • Controlling biochemical and electrical events in neurons with optogenetics; Karl Deisseroth, Stanford University
  • A chemical-genetic solution for the remote control of neuronal activity; Bryan L. Roth, University of North Carolina at Chapel Hill
  • RNA-activated fluorescence switches for RNA imaging and analyte sensing; Samie R. Jaffrey, Weill Medical College of Cornell University
  • To see the meeting program, see: Chemical Probes for Neuroscience Research and Drug Discovery

    Molecular Libraries Special Interest Groups Meeting

    December 13, 2008
    At the American Society for Cell Biology Meeting

    San Francisco, CA

    Registration is now open: click here to register online. (Meeting registration is free.)

    During this session, attendees will hear from MLPCN personnel and biologists who have used these freely available network resources. Speakers will share their experiences with the assay development aspect of the program and describe their specific projects. These projects cover research areas that are of particular interest to meeting attendees, including chromatin dynamics, stem cell development, and cancer biology.

    • Developing Cell-based Assays for High-Throughput Screening of Epigenetic Modulators. Elisabeth Martinez, University of Texas Southwestern Medical Center at Dallas

    • A High-Throughput Screen in Yeast for Compounds That Affect Aging and Age-related Diseases. David Goldfarb, University of Rochester

    • Screening of Phenotypic Responses Induced by Small Molecules in Prostate Cancer Cells Using the HyperCyt High-Throughput Flow Cytometry System. Todd Thompson, University of New Mexico

    • Parallel Multiplicative Target Screening against Diverse Bacterial Replicases: Identification of Specific Inhibitors with Broad Spectrum Potential. Charles McHenry, University of Colorado

    • Synthetic Lethal Screening and Oncogenic-RAS Signaling. Wan Seok Yang, Columbia University

    • Identification of Chemical Probes to Interrogate Complex Biology Using Integrated Biological Screening and Chemistry. Michelle Palmer, Broad Institute

    • Impacting Translational Research via uHTS: Discovery of Specific and Potent Chemical Probes via the Molecular Libraries Initiative. Peter Hodder, The Scripps Research Institute

    • From HTS & HCS to Probe Development: Challenges and successes during the MLSCN Pilot phase of the MLPCN. Thomas Chung, Burnham Institute for Medical Research

    Molecular Libraries Screening Center (MLSCN) Symposium

    April 6, 2008
    At the Society for Biomolecular Sciences Meeting
    St. Louis, MO

    Click here for more information on the MLSCN Symposium: NIH Roadmap Molecular Libraries Screening Centers Network: A Resource for the Research Community

    High Throughput Screening for Neuroscience Meeting

    November 14, 2008
    At the Society for Neuroscience Annual Meeting

    Washington, DC

    Registration is now open: click here to register online. (Meeting registration is free.)

    The High Throughput Screening for Neuroscience is a satellite event of the Annual Meeting of the Society for Neuroscience on November 14, 2008 in Washington DC. This meeting will provide a scientific forum on the burgeoning research activities applying high-throughput screening (HTS) and chemical technologies in neuroscience research. The aims are to enable the rapid translation of new scientific knowledge into tangible benefits for public health. The meeting organizer, NIH Roadmap Molecular Libraries Program (MLP), supports the discovery of new small molecular entities or classes to facilitate basic research and accelerate the development of therapeutics. Meeting participants will learn about state of the art HTS technologies and important progress made by applying HTS approaches.

      • GPCR and Transporter signaling

        • Speakers include: Bryan Roth, University of North Carolina at Chapel Hill; P. Jeffrey Conn, Vanderbilt University; Richard Neubig, University of Michigan; & Eric Delpire, Vanderbilt University
      • Ion Channel – tools and channelopathies

        • Speakers Include: William Catterall, University of Washington; Lily Jan, University of California, San Francisco; Ming Zhou, Columbia University; Grzegorz Bulaj, University of Utah
      • Rare Diseases

        • Speakers Include: Stuart Peltz, PTC therapeutics; Joel M. Gottesfeld, The Scripps Research Institute; Richard A. Gatti, University of California, Los Angeles; Elliot J. Androphy, University of Massachusetts Medical School
      • Emerging Target Areas and HTS Approaches

        • Speakers Include: Lee L. Rubin, Harvard University; Sheng Ding, The Scripps Research Institute; Stephen Haggarty, Harvard Medical School/Broad Institute
      • The Nuts and Bolts of HTS and Probe Production

        • Speakers Include: Christopher P. Austin, NIH Chemical Genomics Center; Min Li, Johns Hopkins University; Craig Lindsley, Vanderbilt University; Jeffrey Aubé, University of Kansas

        For titles and abstracts of each speakers’ talk, please see the meeting program below.

    The purpose of these travel awards is to encourage junior investigators to initiate interdisciplinary interactions with investigators in the fields of neuroscience, neuropharmacology, chemical biology, chemical informatics and drug discovery.