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Events


Chemical Probes for Neuroscience Research and Drug Discovery

October 16, 2009
At the Society for Neuroscience Annual Meeting
Chicago, IL

Registration is now open: click here to register online. (Meeting registration is free.)

Discovery of Disease Targets and Chemical Probes

  • G protein-Independent Receptor Signaling: New Biological and Therapeutic Targets?; Marc G. Caron, Duke University
  • Chemical Probes of Wnt/GSK-3 Signaling in the CNS; Stephen J. Haggarty; Broad Institute
  • Allosteric modulators of GPCRs as a novel approach to treatment of CNS disorders; P. Jeffrey Conn; Vanderbilt University
  • Johns Hopkins Ion Channel Center - When vast chemical diversity meets ion channel targets; Min Li, Johns Hopkins University School of Medicine
  • A Chemical Biology Approach Identifies Modulators of ER Stress: Implications for the Treatment of Neurodegenerative Diseases; Nicholas Cosford, Burnham Institute for Medical Research
  • Creating Zinc Monkey Wrenches: Disease Modification through Epigenetics; Alan P. Kozikowski, University of Illinois Chicago
  • Modulating Beta-Secretase Activity, Evolution from Inhibitors to Drugs; Jordan J. Tang, University of Oklahoma Health Science Center

    • Innovative Molecular Probes for Neuroscience Research

  • Probing Neuroreceptors and Ion Channels with Unnatural Amino Acids; Dennis A. Dougherty, California Institute of Technology
  • Rewiring GPCR Signals in vivo with RASSLs; Bruce R. Conklin, University of California, San Francisco
  • Controlling biochemical and electrical events in neurons with optogenetics; Karl Deisseroth, Stanford University
  • A chemical-genetic solution for the remote control of neuronal activity; Bryan L. Roth, University of North Carolina at Chapel Hill
  • RNA-activated fluorescence switches for RNA imaging and analyte sensing; Samie R. Jaffrey, Weill Medical College of Cornell University

    • To see the meeting program, see: Chemical Probes for Neuroscience Research and Drug Discovery

    Past Meetings

    Molecular Libraries Special Interest Groups Meeting

    December 13, 2008
    At the American Society for Cell Biology Meeting
    San Francisco, CA

    Registration is now open: click here to register online. (Meeting registration is free.)

    During this session, attendees will hear from MLPCN personnel and biologists who have used these freely available network resources. Speakers will share their experiences with the assay development aspect of the program and describe their specific projects. These projects cover research areas that are of particular interest to meeting attendees, including chromatin dynamics, stem cell development, and cancer biology.

    • Developing Cell-based Assays for High-Throughput Screening of Epigenetic Modulators. Elisabeth Martinez, University of Texas Southwestern Medical Center at Dallas

    • A High-Throughput Screen in Yeast for Compounds That Affect Aging and Age-related Diseases. David Goldfarb, University of Rochester

    • Screening of Phenotypic Responses Induced by Small Molecules in Prostate Cancer Cells Using the HyperCyt High-Throughput Flow Cytometry System. Todd Thompson, University of New Mexico

    • Parallel Multiplicative Target Screening against Diverse Bacterial Replicases: Identification of Specific Inhibitors with Broad Spectrum Potential. Charles McHenry, University of Colorado

    • Synthetic Lethal Screening and Oncogenic-RAS Signaling. Wan Seok Yang, Columbia University

    • Identification of Chemical Probes to Interrogate Complex Biology Using Integrated Biological Screening and Chemistry. Michelle Palmer, Broad Institute

    • Impacting Translational Research via uHTS: Discovery of Specific and Potent Chemical Probes via the Molecular Libraries Initiative. Peter Hodder, The Scripps Research Institute

    • From HTS & HCS to Probe Development: Challenges and successes during the MLSCN Pilot phase of the MLPCN. Thomas Chung, Burnham Institute for Medical Research

    Molecular Libraries Screening Center (MLSCN) Symposium

    April 6, 2008
    At the Society for Biomolecular Sciences Meeting
    St. Louis, MO

    Click here for more information on the MLSCN Symposium: NIH Roadmap Molecular Libraries Screening Centers Network: A Resource for the Research Community

    High Throughput Screening for Neuroscience Meeting

    November 14, 2008
    At the Society for Neuroscience Annual Meeting
    Washington, DC

    Registration is now open: click here to register online. (Meeting registration is free.)

    The High Throughput Screening for Neuroscience is a satellite event of the Annual Meeting of the Society for Neuroscience on November 14, 2008 in Washington DC. This meeting will provide a scientific forum on the burgeoning research activities applying high-throughput screening (HTS) and chemical technologies in neuroscience research. The aims are to enable the rapid translation of new scientific knowledge into tangible benefits for public health. The meeting organizer, NIH Roadmap Molecular Libraries Program (MLP), supports the discovery of new small molecular entities or classes to facilitate basic research and accelerate the development of therapeutics. Meeting participants will learn about state of the art HTS technologies and important progress made by applying HTS approaches.

      • GPCR and Transporter signaling

        • Speakers include: Bryan Roth, University of North Carolina at Chapel Hill; P. Jeffrey Conn, Vanderbilt University; Richard Neubig, University of Michigan; & Eric Delpire, Vanderbilt University

      • Ion Channel - tools and channelopathies

        • Speakers Include: William Catterall, University of Washington; Lily Jan, University of California, San Francisco; Ming Zhou, Columbia University; Grzegorz Bulaj, University of Utah

      • Rare Diseases

        • Speakers Include: Stuart Peltz, PTC therapeutics; Joel M. Gottesfeld, The Scripps Research Institute; Richard A. Gatti, University of California, Los Angeles; Elliot J. Androphy, University of Massachusetts Medical School

      • Emerging Target Areas and HTS Approaches

        • Speakers Include: Lee L. Rubin, Harvard University; Sheng Ding, The Scripps Research Institute; Stephen Haggarty, Harvard Medical School/Broad Institute

      • The Nuts and Bolts of HTS and Probe Production

        • Speakers Include: Christopher P. Austin, NIH Chemical Genomics Center; Min Li, Johns Hopkins University; Craig Lindsley, Vanderbilt University; Jeffrey Aubé, University of Kansas

        For titles and abstracts of each speakers’ talk, please see the meeting program below.

    The purpose of these travel awards is to encourage junior investigators to initiate interdisciplinary interactions with investigators in the fields of neuroscience, neuropharmacology, chemical biology, chemical informatics and drug discovery.