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(90) Direct Publications in 2008




  1. A comparative analysis of standard microtiter plate reading versus imaging in cellular assays. Bushway, P., Mercola, M. & Price, J. Assay and Drug Development Technologies, 2008, 6(4): 557-567.
  2. Automated Calcium Measurements in Live Cardiomyocytes Charlot, D., Campa, V., Mercola, M., Ingermanson, R., McDonough, P.M., & Price, J.H. 2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Proceedings, ISBI, art. no. 4540996:316-319.
  3. Rapid Multistep Synthesis of 1,2,4-Oxadiazoles in a Single Continuous Microreactor Sequence. Grant D., Dahl R., Cosford, N. D. J Org Chem, 2008, 73(18): 7219-7223.
  4. High throughput synthesis of peptide α-thioesters through the use of “volatilizable” support. Li, Y., Yu, Y., Giulianotti, M., & Houghten, R.A. J Comb Chem, 2008, 10(5): 613-616.
  5. Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors. Noberini, R., Koolpe, M., Peddibhotla, S., Dahl, R., Su, Y., Cosford, N. D. P., Roth, G. P., & Pasquale, E. B. J Biol Chem, 2008, 283: 29461-29472.
  6. Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 Receptor. Qin. H., Shi, J., Noberini, R., Pasquale, E. B., & Song. J. J Biol Chem, 2008, 283: 29473-29484.
  7. Digital differential interference contrast autofocus for high-resolution oil-immersion microscopy. Shen, F., Hodgson, L., Price, J.H., & Hahn, K.M. Cytommetry A, 2008, 73(7): 658-666.
  8. A TR3/Nur77 Peptide-Based High Throughput Fluorescence Polarization Screen for Small Molecule Bcl-B Inhibitors. Yip, K.W., Godoi, P.H.C., Zhai, D., Garcia, X., Cellitti, J.F., Cuddy, M., Gerlic, M., Chen, Y., Satterthwait, A., Vasile, S.,  Sergienko, E., and Reed.  J.C., J Biomol Screening, 2008, 13(7): 665-673.

Columbia (MLSCN)


Emory (MLSCN)

  1. Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein (Hsp90): Synthesis, biology, and molecular modeling. Ganesh, T., Min, J., Thepchatri, P., Du, Y., Li, L., Lewis, I., Wilson, L., Fu, H., Chiosis, G., Dingledine, R., Liotta, D., Snyder, J. & Sun, A. Bioorg. Med. Chem., 2008, 16(14):6903-6910.


  1. Characterization of chemical libraries for luciferase inhibitory activity. Auld, D.S., Southall, N., Jadhav, A., Johnson R.L., Diller D., Simeonov A., Austin, C.P, & Inglese, J. Journal of Medicinal Chemistry, 2008, 10.1021/jm701302v
  2. Specific Mechanism for Nonspecific Activation in Reporter-Gene Assays. Auld, D.S., Thorne, N., Nguyen, D.T. & Inglese, J.A. Chemical Biology, 2008, 3(8): 463-470.
  3. Molecular Sensors for Transcriptional and Post-transcriptional Assays, in Chemical Genomics. Auld, D.S., & Thorne, N. Cambridge University Press, Fu, H., ed. 2008.
  4. Comprehensive Mechanistic Analysis of Hits from High-Throughput and Docking Screens against beta-Lactamase. Babaoglu, K., Simeonov, A., Irwin, J., Nelson, M., Feng, B., Thomas, C., Cancian, L., Costi, M., Maltby, D., Jadhav, A., Austin, C., Shoichet, B. J Med Chem., 2008, 51(8): 2502-2511.
  5. COPI complex is a regulator of lipid homeostasis. Beller, M., Sztalryd, C., Southall, N., Bell, M., Jackle, H., Auld, D.S. & Oliver, B. PLoS Biol, 2008, 6(11): e292. doi:10.1371/journal.pbio.0060292
  6. A bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker. Cho, M.H., Niles, A., Huang, R., Inglese, J., Austin, C.P., Riss, T. & Xia, M. Toxicol In Vitro, 2008, 22(4): 1099-1106.
  7. Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2007. Dolle, R., Le Bourdonnec, B., Goodman, A., Morales, G., Thomas, C., Zhang, W. J. Comb Chem., 2008, 10(6): 753-802.
  8. A virtual screen for diverse ligands: discovery of selective G protein-coupled receptor antagonists. Engel, S., Skoumbourdis, A.P., Childress, J., Neumann, S., Deschamps, J.R., Thomas, C.J., Colson, A.O., Costanzi, S., & Gershengorn, M.C. J Am Chem Soc, 2008, 130 (15): 5115-5123.
  9. Characterization of diversity in toxicity mechanisms using in vitro cytotoxicity assays in quantitative high throughput screening. Huang, R., Southall, N., Cho, M.H., Xia, M., Inglese, J., & Austin, C.P. Chem. Res. Toxicol., 2008, 21(3): 659–667.
  10. High Throughput Screening (HTS) Techniques: Overview of Applications in Chemical Biology. Inglese, J., & Auld, D.S. In Wiley Encyclopedia of Chemical Biology, 2008, Begley, T., ed, John Wiley & Sons, Inc.
  11. Examining the Chirality, Conformation and Selective Kinase Inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550). Jiang, J.K., Ghoreschi, K., Deflorian, F., Chen, Z., Perreira, M., Pesu, M., Smith, J., Nguyen, D.T., Liu, E.H., Leister, W., Costanzi, S., O’Shea, J.J., Thomas, C.J. Journal of Medicinal Chemistry, 2008, In press.
  12. A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression. Johnson, R., Huang, W., Jadhav, A., Austin, C.P., Inglese, J., & Martinez, E.D. Analytical Biochemistry, 2008, 375: 237-248.
  13. Tetracycline-Inducible Gene Expression in Conditionally Immortalized Mouse Podocytes. Kajiyama, H., Titus, S., Austin, C., Chiotos, K., Matsumoto, T., Sakairi, T. & Kopp, J. American Journal of Nephrology, 2008, 29: 153-163.
  14. Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment. Kavlock, R.J., Austin, C.P. & Tice, R.R. Assay and Drug Development Technologies, 2008, 6: 551-555.
  15. A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction. Kimple, A.J., Yasgar, A., Hughes, M., Jadhav, A., Willard, F.S., Muller, R.E., Austin, C.P., Inglese, J., Ibeanu, G.C., Siderovski, D.P. & Simeonov, A. Comb Chem High Throughput Screen, 2008, 11(5): 396-409.
  16. A 1,536-Well-Based Kinetic HTS Assay for Inhibitors of Schistosoma mansoni Thioredoxin Glutathione Reductase.Lea, W.A., Jadhav, A., Rai, G., Sayed, A., Cass, C., Inglese, J., Williams, D., Austin, C.P. & Simeonov, A. Assay and Drug Development Technologies, 2008, 6: 551-555.
  17. Comparison on Functional Assays for Gq-coupled GPCRs by Measuring Inositol Monophospate and Intracellular Calcium in 1536-well Plate Format. Liu, K., Titus, S., Southall, N., Zhu, P., Inglese, J., Austin, C.P. & Zheng,W. Current Chemical Genomics, 2008, 1:70-78.
  18. Comparison of Raltegravir and Elvitagravir on HIV-1 Integrase Catalytic Reactions and on a Series of Drug-Resistant Integrase Mutants. Marinello, J., Marchand, C., Mott, B.T., Bain, A., Thomas, C.J., Pommier, Y. Biochemistry, 2008, 27(36): 9345-9354.
  19. A robotics platform for quantitative high-throughput screening. Michael, S., Auld, D., Klumpp, C., Jadhav, A., Zheng, W., Thorne, N., Austin, C.P., Inglese, J. & Simeonov A. Assay and Drug Development Technologies, 2008, 6(5): 637-657.
  20. A Low-Molecular-Weight Antagonist for the Human Thyrotropin Receptor with Therapeutic Potential for Hyperthyroidism. Neumann, S., Kleinau, G., Costanzi, S., Moore, S., Jiang, J.K., Raaka , B.M., Thomas, C.J., Krause, G., & Gershengorn, M.C. Endocrinology, 2008, 149(12): 5945-5950.
  21. Selective targeting of ITK blocks multiple steps of HIV replication. Readinger, J.A., Schiralli, G.M., Jiang, J.K., Thomas, C.J., August, A., Henderson, A.J. & Schwartzberg, P.L. Proc Natl Acad Sci USA, 2008, 105(18): 6684-6689.
  22. Identification of oxadiazoles as new drug leads for control of schistosomiasis. Sayed, A.A., Simeonov, A., Thomas, C.J., Inglese, J., Austin, C.P., & Williams, D.L. Nature Medicine, 2008, 14: 407-412.
  23. Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade. Simeonov, A., Jadhav, A., Sayed, A.A., Wang, Y., Nelson, M.E., Thomas, C.J., Inglese, J., Williams, D.L., & Austin, C.P. PLoS Negl Trop Dis, 2008, 2(1):1-10.
  24. Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction. Simeonov, A., Yasgar, A., Jadhav, A., Lokesh, G.L., Klumpp, C., Michael, S., Austin, C.P., Natarajan, A., & Inglese, J. Analytical Biochemistry, 2008, 375: 60-70.
  25. Fluorescence Spectroscopic Profiling of Compound Libraries. Simeonov, A., Jadhav, A., Thomas, C.J., Wang, Y., Huang, R., Southall, N., Shinn, P., Smith, J., Austin, C.P., & Inglese, J. Journal of Medicinal Chemisty, 2008, In Press.
  26. Identification of a potent new chemotype for the selective inhibition of PDE4. Skoumbourdis, A.P., Huang, R., Southall, N., Leister, W., Guo, V., Cho, M.H., Inglese, J., Nirenberg, M., Austin, C.P., Xia, M., & Thomas, C.J. Bioorganic and Medicinal Chemistry Letters, 2008, 18 (4):1297-1303.
  27. Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor. Titus, S., Neumann, S., Zheng, W., Southall, N., Michael, S., Klumpp, C., Yasgar, A., Shinn, P., Thomas, C.J., Inglese, J., Gershengorn, M.C., & Austin, C.P. Journal of Biomolecular Screening, 2008, 13(2):120-127.
  28. A Cell-Based PDE4 Assay in 1536-Well Plate Format for High-Throughput Screening. Titus, S., Xiao, L., Southall, N., Lu, J., Inglese, J., Brasch, M., Austin , C. P. & Zheng, W. Journal of Biomolecular Screening, 2008, In press.
  29. Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor. Titus, S., Neumann, S., Zheng, W., Southall, N., Michael, S., Klumpp, C., Yasgar, A., Shinn, P., Thomas, C.J., Inglese, J., Gershengorn, M.C., Austin, C.P. J Biomol Screen., 2008, 13:120-7.
  30. Optimization and Validation of Two Miniaturized Glucocerebrosidase Enzyme Assays for High Throughput Screening. Urban, D.J., Zheng, W., Goker-Alpan, O., Jadhav, A., LaMarca, M.E., Inglese, J., Sidransky, E. & Austin, C.P. Combinatorial Chemistry & High Throughput Screening, 2008, 11(10):817-824.
  31. Compound cytotoxicity profiling using quantitative high-throughput screening. Xia, M., Huang, R., Witt, K.L., Southall, N., Fostel, J., Cho, M.H., Jadhav, A., Smith, C.S., Inglese, J., Portier, C.J., Tice, R.R., & Austin, C.P. Environmental Health Prospectives, 2008, In press.
  32. Identification of N-(quinoline-8-yl)bezenesulfonamides as agents capable of down-regulating NFkB activity within two separate high-throughput screens of NFkB activation. Xie, Y., Deng, S., Thomas, C.J., Liu, Y., Zhang, Y-Q., Rinderspacher, A., Huang, W., Gong, G., Wyler, M., Cayanis, E., Aulner, N., Tobben, U., Chung, C.,Pampou, S., Southall, N., Vidovic, D., Schurer, S.,Branden, L., Davis, R. E., Staudt, L. M., Inglese, J., Austin, C.P., Landry, D.W., Smith, D.H., & Auld, D.S. Bioorganic and Medicinal Chemistry Letters, 2008, 18: 329-335.
  33. Compound management for quantitative high-throughput screening. Yasgar, A., Shinn, P., Jadhav, A., Auld, D.S., Michael, S., Zheng, W., Austin, C.P., Inglese, J., & Simeonov, A. Journal of the Association for Laboratory Automation, 2008, 12(2): 79-89.
  34. A novel class of small molecule inhibitors of Hsp90. Yi, F., & Regan, L. ACS Chemical Biology, 2008, 3(10):645-654.
  35. A miniaturized glucocorticoid receptor translocation assay using enzymatic fragment complementation evaluated with qHTS. Zhu, P.J., Zheng, W., Auld, D.S., Jadhav, A., Macarthur, R., Olson , K.R., Peng, K., Dotimas, H., Austin, C.P., Inglese, J. Combinatorial Chemistry & High Throughput Screening, 2008, 11(7): 545-559.

New Mexico

  1. A Multifunctional Androgen Receptor Screening (MARS) Assay for the Identification of Compounds that Modulate Androgen Receptor Activity Using the High-Throughput HyperCyt® Flow Cytometry System. Dennis, M., Bowles, H., MacKenzie, D., Burchiel, S., Edwards, B., Sklar, L., Prossnitz, E., & Thompson, T. Cytometry, 2008, 7: 390-399
  2. High content screening: flow cytometry analysis. Edwards, B.S., Young, S.M., Ivnitski-Steele, I., Ye, R., Prossnitz, E. & Sklar, L. In Cell Based Assays in High-Throughput Screening. Clemons, P.A., Tolliday, N.J. & Wagner, B.K., eds. Humana Press, Inc, Totowa, NJ. In Press 2008.
  3. High-throughput flow cytometry to detect selective inhibitors of ABCB1, ABCC1, and ABCG2 transporters. Ivnitski-Steele, I., Lawson, R.S., Lovato, D.M., Khawaja, H.M., Winter, S.S., Oprea, T.I., Sklar L.A., & Edwards, B.S. Assay and Drug Development Technologies, 2008, 6(2): 263-276.
  4. Preclinical development of a neutral, estrogen receptor-targeted, tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivative for imaging of breast and endometrial cancers. Nayak, T.K., Hathaway, H.J., Ramesh, C., Arterburn, J.B., Dai, D., Sklar, L.A., Norenberg, J.P., Prossnitz, E.R. J Nucl Med, 2008, 49(6): 978-986.
  5. Estrogen Signaling through the Transmembrane G protein-coupled Receptor GPR30. Prossnitz, E., Arterburn, J., Smith, H., Oprea, T., Sklar, L. & Hathaway H. Ann Rev Physiol, 2008, 70, 165-190.
  6. GPR30: a novel therapeutic target in estrogen-related disease. Prossnitz, E., Arterburn, J., Oprea, T., & Sklar, L.TIPS, 2008, 29, 116-123.
  7. The ins and outs of GPR30: A transmembrane estrogen receptor. Prossnitz, E.R., Oprea, T.I., Sklar, L.A., & Arterburn, J.B. J. Steroid. Biochem Mol Biol, 2008, 109(3-5): 350-353.
  8. Advances in Multiple Analyte Profiling. Salas, V., Edwards, B., & Sklar, L. Adv Clin Chem, 2008, 45: 47-74.
  9. Flow Cytometry Multiplexed Screening Methodologies. Salas, V., Strouse, J.J., Edwards, B.S., & Sklar, L.A. In Chemical Genomics Assays and Screens. Fu, H., Ed. Cambridge University Press. In Press 2008.
  10. Flow Cytometry for Real-Time Measurement of Guanine Nucleotide Binding and Exchange by Ras-like GTPases Schwartz, S.L., Tessema, M., Buranda, T., Pylypenko, O., Rak, A., Simons, P.C., Surviladze, Z., Sklar, L.A., & Wandinger-Ness, A. Anal. Biochem., 2008, 381(2):258-266.
  11. Identification of Off-Patent Drugs That Reverse Daunorubicin Efflux Mediated by ABCB1 in T-ALL Cells. Winter, S,. Lovato, D., Khawaja, H., Edwards, B., Ivnitski-Steele. I., Young, S.,Estes, D., Oprea, T., Sklar, L., & Larson, R. SBS, 2008, 15: 185-193.
  12. High Throughput Screening for Daunorubicin-mediated Drug Resistance Identifies Mometasone Furoate as a Novel ABCB1 Reversal Agent. Winter, S.S., Lovato, D.M., Khawaja, H.M., Edwards, B.S., Ivnitski-Steele, I.D., Young, S.M., Oprea, T.I., Sklar, L.A. & Larson, R.S. J. Biomol Screen, 2008, 13: 185-193.
  13. Detection of membrane biointeractions based on fluorescence superquenching. Zeineldin, R., Piyasena, M., Sklar, L., Whitten, D., Lopez, G. Langmuir, 2008, 24:4125-4131.

Penn (MLSCN)

  1. Molecular docking of cathepsin L inhibitors in the binding site of papain. Beavers, M., Myers, M., Shaw, P., Diamond, S., & Smith, A. J Chem Information & Modeling, 2008, 48(7):1464-1472.
  2. A Saccharomyces cerevisiae cell-based quantitative beta-galactosidase assay compatible with robotic handling and high-throughput screening. deAlmeida, R.A., Burgess, D., Shema, R., Motlekar, N., Napper, A.D., Diamond, S.L. & Pavitt., G.D. Yeast, 2008, 25: 71-76.
  3. Evaluation of an orthogonal pooling strategy for rapid high throughput screening of proteases. Moltekar, N., Diamond, S.L., & Napper, A. Assay & Drug Dev Tech, 2008, 6(3): 395-405.
  4. Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor. Myers, M.C., Shah, P.P., Diamond, S.L., Huryn, D.M., & Smith, A.B. Bioorganic and Medicinal Chemistry Letters, 2008, 18, 210-214.
  5. Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype. Myers, M., Shah, P., Beavers, M., Napper, A., Diamond, S., Smith, A., & Huyrn, D. Bioorg. Med. Chem. Lett., 2008, 18(12):3646-3651.
  6. Kinetic characterization and molecular docking of a novel, potent and selective slow-binding inhibitor of human cathepsin L. Shah, P., Myers, M., Beavers, M., Pruvis, J., Huryn, D., Smith, A., & Diamond, S. Molec Pharmacol, 2008, In press.
  7. Enzyme microarrays assembled by acoustic dispensing technology. Wong, E., & Diamond, S. Anal. Biochem., 2008, 381(1):101-106.

Pittsburgh (MLSCN)

  1. Toward a molecular understanding of the interaction of dual specificity phosphatases with substrates: Insights from structure-based modeling and high throughput screening. Bakan, A, Lazo, J., Wipf, P., Brummond K., & Bahar, I. Current Med Chem, 2008, in press.
  2. Is Cdc25 a druggable target? Lazo, J., & Wipf P. Anti-cancer Agents Med Chem, 2008, In press.
  3. Potent and selective disruption of protein kinase d functionality by a benzoxoloazepinolone. Sharlow, E.R., Giridhar, K., Lavelle, C., Chen, J., Leimgruber, S., Barrett, R., Bravo-Altamirano, K., Wipf, P., Lazo, J., & Wang, Q. J Biol Chem, 283(48): 33516-33526.
  4. Development, validation and implementation of immobilized metal affinity for phosphochemical (IMAP)-based fluorescence polarization (FP) and timed resolved-fluorescence resonance energy transfer (TR-FRET) high throughput screening assays. Sharlow, E., Leimgruber, S., Yellow-Duke, A., Barrett, R., Wang, Q., & Lazo, J.S. Nature Protocols, 2008, In Press.
  5. A cell-active inhibitor of mitogen activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells. Vogt, A., McDonald, P.R., Tamewitz, A., Sikorski, R., Wipf, P., Skoko, J.J., & Lazo, J.S. Molecular Cancer Therapeutics, 2008, In press.
  6. Data mining a small molecule drug screening representative subset from NIH PubChem. Xie, X.-Q. & Chen, J.-Z. Journal of Chemical Information and Modeling, 48(3): 465-475.


  1. Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method. Dai, S., Chalmers, M., Bruning, J., Bramlett, K., Osborne, H., Montrose-Rafizadeh, C., Barr, R., Wang, Y., Wang, M., Burris, T., Dodge, J., & Griffin, P. Proc Natl Acad Sci USA, 2008, 105: 7171-7176.
  2. A fluorescent plate reader assay for ceramide kinase. Don, A.S., & Rosen, H. Analytical Biochemistry, 2008, 375(2): 265-271.
  3. Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. Gonzalez-Cabrera, P.J., Jo, E., Sanna, M.G., Brown, S., Leaf, N., Marsolais, D., Schaeffer, M.T., Chapman, J., Cameron, M., Guerrero, M., Roberts, E. & Rosen, H. Mol Pharmacol, 2008, 74(5): 1308-1318.
  4. Utilizing high throughput screening data for predictive toxicology models: protocols and application to MLSCN assays. Guha, R., & Schurer, S. Comp Aided Mol Des, 2008, 22: 367-384.
  5. High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate. Lauer-Fields, J.L., Minond, D., Chase, P., Baillargeon, P., Saldanha, S., Stawikowska, R., Hodder, P., & Fields, G. Bioorg & Med Chem Letters, 2008, 17(3):990-1005.
  6. Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate. Lauer-Fields, J.L., Spicer, T.P., Chase, P.S., Cudic, M., Burstein, G.D., Nagase, H., Hodder, P. & Fields, GB. Analytical Biochemistry, 2008, 373: 43-51.
  7. Potent, selective and cell penetrant inhibitors of SF-1 by functional uHTS. Madoux, F., Li, X., Chase, P., Zastrow, G., Cameron, M.D., Conkright, J.J., Griffin, P.R., Thacher, S. & Hodder, P. Molecular Pharmacology, 2008, 73(6): 1776-1784.
  8. Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune response to influenza. Marsolais, D., Hahm,B., Edelmann, K.H., Walsh, K.B., Guerrero, M., Hatta, Y., Kawaoka, Y., Roberts, E., Oldstone, M.B. & Rosen, H. Mol Pharmacol, 2008, 74(3): 896-903.
  9. Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study. Nakai, R., Salisbury, C.M., Rosen, H., & Cravatt, B.F. Bioorganic & Medicinal Chemistry, 2008, 17(3):1101-1108.
  10. Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation. Niessen, F., Schaffner, F., Furlan-Freguia, C., Pawlinski, R., Bhattacharjee, G., Chun, J., Derian, C. K., Andrade-Gordon, P., Rosen, H., Ruf, W. Nature, 2008, 452: 654-658.
  11. Modulating tone: the overture of S1P receptor immunotherapeutics. Rosen, H., Gonzalez-Cabrera, P., Marsolais, D., Cahalan, S., Don, A. S., Sanna, M. G. Immunol Rev, 2008, 223: 221-235.
  12. Synthesis of Small Molecule Inhibitors of the Orphan Nuclear Receptor Steroidogenic Factor-1 (NR5A1) Based on Isoquinolinone Scaffolds. Roth, J., Madoux, F., Hodder, P. & Roush, W. Bioorg Med Chem Lett, 2008, 18(8): 2628-2632.
  13. Comparison of Miniaturized Time-Resolved Fluorescence Resonance Energy Transfer and Enzyme-Coupled Luciferase High-Throughput Screening Assays to Discover Inhibitors of Rho-Kinase II (ROCK-II). Schröter, T., Minond, D., Weiser, A., Dao, C., Habel, J., Spicer, T., Chase, P., Baillargeon, P., Scampavia, L., Schürer, S., Chung, C., Mader, C., Southern, M., Tsinoremas, N., LoGrasso, P., & Hodder, P. J Biomolecular Screening, 2008, 13(1):17-28.
  14. Ligand-binding pocket shape differences between S1P1 and S1P3 determine efficiency of chemical probe identification by uHTS. Schürer, S., Brown, S., Gonzales Cabrera, P., Schaeffer, M-T., Chapman, J., Jo, E., Chase, P., Spicer, T., Hodder, P. & Rosen, H. ACS Chem Biol, 2008, 3(8): 486-498.

Southern Research Institute

  1. Adapting Cell Based Assays to the High Throughput Screening Platform: Problems Encountered and Lessons Learned. Maddox, C.B., Rasmussen, L., & White, E.L.,J. Assoc. Lab. Automation, 2008, 13:168-173.




  1. A novel assay of Gi/o-linked G protein coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors. Niswender, C.M., Johnson, K.A., Luo, Q., Ayala, J., Kim, C., Conn, P.J., & Weaver, D. Molec Pharmacology, 2008, In press.
  2. An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Shirey, J.K., Xiang, Z., Orten, D., Brady, A.E., Johnson, K.A., Williams, R., Ayala, J.E., Rodriquez, A.L., Wess, J., Weaver, D., Niswender, C., & Conn, J.P. Nature Chemical Biology, 2008, 4: 42-50.
  3. Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists. Lewis, M., Sheffler, D., Williams, R., Bridges, T., Kennedy, J.P., Brogan, J.T., Mulder, M.J., Williams, L., Nalywajko, N.T., Niswender, C., Weaver, D., Conn, P.J., Lindsley, C.W. Bioorg & Med Chem Lett, 2008, 885-890.



Other Institutions

  1. Differentiation of AmpC beta-lactamase binders vs. decoys using classification kNN QSAR modeling and application of the QSAR classifier to virtual screening. Hsieh, J-H., Wang, X.S., Teotico, D., Golbraikh, A. & Tropsha, A. J Comput Aided Mol Des, 2008, DOI 10.1007/s10822-008-9199-2
  2. Use of cell viability data improves the prediction accuracy of conventional quantitative structure-activity relationship models of animal carcinogenicity. Zhu, H., Rusyn, I., Richard, A. & Tropsha, A. Environmental Health Perspectives, 2008, 116, 4: 506-513.