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Indirect Publications

The indirect publications which cite publications from the MLPCN or MLSCN centers are listed below. You can access  a specific year by clicking on the links in the left menu.

2009

Abdul-Ghani, R., Loutfy, N., Sahn, A. E., & Hassan, A. (2009). Current chemotherapy arsenal for schistosomiasis mansoni: Alternatives and challenges. Parasitology Research, 104(5), 955-965.

Abdul-Ghani, R. A., Loutfy, N., & Hassan, A. (2009). Experimentally promising antischistosomal drugs: A review of some drug candidates not reaching the clinical use. Parasitology Research, 105(4), 899-906.

Abulafia, D. P., De Rivero Vaccari, J. P., Lozano, J. D., Lotocki, G., Keane, R. W., & Dietrich, W. D. (2009). Inhibition of the inflammasome complex reduces the inflammatory response after thromboembolic stroke in mice. Journal of Cerebral Blood Flow and Metabolism, 29(3), 534-544.

Allgeier, S. H., Vezina, C. M., Lin, T. -., Moore, R. W., Silverstone, A. E., Mukai, M., et al. (2009). Estrogen signaling is not required for prostatic bud patterning or for its disruption by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology and Applied Pharmacology, 239(1), 80-86.

Ananthan, S., Zhang, W., & Hobrath, J. V. (2009). Recent advances in structure-based virtual screening of G-protein coupled receptors. AAPS Journal, 11(1), 178-185.

Andersen, M. E., & Krewski, D. (2009). Toxicity testing in the 21st century: Bringing the vision to life. Toxicological Sciences, 107(2), 324-330.

Angelopoulos, N., Hadjiprocopis, A., & Walkinshaw, M. D. (2009). Bayesian model averaging for ligand discovery. Journal of Chemical Information and Modeling, 49(6), 1547-1557.

Antony, J., Kellershohn, K., Mohr-Andrä, M., Kebig, A., Prilla, S., Muth, M., et al. (2009). Dualsteric GPCR targeting: A novel route to binding and signaling pathway selectivity. FASEB Journal, 23(2), 442-450.

Arkin, M. R., & Whitty, A. (2009). The road less traveled: Modulating signal transduction enzymes by inhibiting their protein-protein interactions. Current Opinion in Chemical Biology, 13(3), 284-290.

Auld, D. S., Zhang, Y. -., Southall, N. T., Rai, G., Landsman, M., MacLure, J., et al. (2009). A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution. Journal of Medicinal Chemistry, 52(5), 1450-1458.

Bachovchin, D. A., Brown, S. J., Rosen, H., & Cravatt, B. F. (2009). Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes. Nature Biotechnology, 27(4), 387-394.

Barton, M., & Meyer, M. R. (2009). Postmenopausal hypertension: Mechanisms and therapy. Hypertension, 54(1), 11-18.

Baškovč, J., Bevk, D., Stanovnik, B., & Svete, J. (2009). Bis-enaminone based parallel solution-phase synthesis of 1,4-dihydropyridine derivatives. Journal of Combinatorial Chemistry, 11(3), 500-507.

Baxendale, I. R., Ley, S. V., Mansfield, A. C., & Smith, C. D. (2009). Multistep synthesis using modular flow reactors: Bestmann-ohira reagent for the formation of alkynes and triazoles. Angewandte Chemie – International Edition, 48(22), 4017-4021.

Bayne, C. J. (2009). Successful parasitism of vector snail biomphalaria glabrata by the human blood fluke (trematode) schistosoma mansoni: A 2009 assessment. Molecular and Biochemical Parasitology, 165(1), 8-18.

Bergsbaken, T., Fink, S. L., & Cookson, B. T. (2009). Pyroptosis: Host cell death and inflammation. Nature Reviews Microbiology, 7(2), 99-109.

Berrodin, T. J., Chang, K. C. N., Komm, B. S., Freedman, L. P., & Nagpal, S. (2009). Differential biochemical and cellular actions of premarin estrogens: Distinct pharmacology of bazedoxifene-conjugated estrogens combination. Molecular Endocrinology, 23(1), 74-85.

Bharate, S. B., Nemmani, K. V. S., & Vishwakarma, R. A. (2009). Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): An emerging target for type 2 diabetes. Expert Opinion on Therapeutic Patents, 19(2), 237-264.

Bickel, P. E., Tansey, J. T., & Welte, M. A. (2009). PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores. Biochimica Et Biophysica Acta – Molecular and Cell Biology of Lipids, 1791(6), 419-440.

Biersack, B., & Schobert, R. (2009). Metallodrug conjugates with steroids and selective estrogen receptor modulators (SERM). Current Medicinal Chemistry, 16(18), 2324-2337.

Biffinger, J., Ribbens, M., Ringeisen, B., Pietron, J., Finkel, S., & Nealson, K. (2009). Characterization of electrochemically active bacteria utilizing a high-throughput voltage-based screening assay. Biotechnology and Bioengineering, 102(2), 436-444.

Blackburn, W. H., Dickerson, E. B., Smith, M. H., McDonald, J. F., & Lyon, L. A. (2009). Peptide-functionalized nanogels for targeted siRNA delivery. Bioconjugate Chemistry, 20(5), 960-968.

Blaskovich, M. A. T. (2009). Drug discovery and protein tyrosine phosphatases. Current Medicinal Chemistry, 16(17), 2095-2176.

Blom, W. M., van Nielen, W. G. L., de Groene, E. M., & Albers, R. (2009). A cell-based screening assay for natural killer cell activity. International Immunopharmacology, 9(6), 746-752.

Blum, L. C., & Reymond, J. -. (2009). 970 million druglike small molecules for virtual screening in the chemical universe database GDB-13. Journal of the American Chemical Society, 131(25), 8732-8733.

Bogdan, A. R., & Sach, N. W. (2009). The use of copper flow reactor technology for the continuous synthesis of 1,4-disubstituted 1,2,3-triazoles. Advanced Synthesis and Catalysis, 351(6), 849-854.

Boisselier, E., & Astruc, D. (2009). Gold nanoparticles in nanomedicine: Preparations, imaging, diagnostics, therapies and toxicity. Chemical Society Reviews, 38(6), 1759-1782.

Bourque, M., Dluzen, D. E., & Di Paolo, T. (2009). Neuroprotective actions of sex steroids in parkinson’s disease. Frontiers in Neuroendocrinology, 30(2), 142-157.

Bouskine, A., Nebout, M., Brücker-Davis, F., Banahmed, M., & Fenichel, P. (2009). Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor. Environmental Health Perspectives, 117(7), 1053-1058.

Brady, L. S., Winsky, L., Goodman, W., Oliveri, M. E., & Stover, E. (2009). NIMH initiatives to facilitate collaborations among industry, academia, and government for the discovery and clinical testing of novel models and drugs for psychiatric disorders. Neuropsychopharmacology, 34(1), 229-243.

Brannan, J. M., Dong, W., Prudkin, L., Behrens, C., Lotan, R., Bekele, B. N., et al. (2009). Expression of the receptor tyrosine kinase EphA2 is increased in smokers and predicts poor survival in non -small cell lung cancer. Clinical Cancer Research, 15(13), 4423-4430.

Brinton, R. D. (2009). Estrogen-induced plasticity from cells to circuits: Predictions for cognitive function. Trends in Pharmacological Sciences, 30(4), 212-222.

Brufani, M., Ceccacci, F., Filocamo, L., Garofalo, B., Joudioux, R., Bella, A. L., et al. (2009). Novel locally active estrogens accelerate cutaneous wound healing. A preliminary study. Molecular Pharmaceutics, 6(2), 543-556.

Bryant, C., & Fitzgerald, K. A. (2009). Molecular mechanisms involved in inflammasome activation. Trends in Cell Biology, 19(9), 455-464.

Burr, I., Winchester, T., Keighley, W., & Sewing, A. (2009). Compound management beyond efficiency. Journal of Biomolecular Screening, 14(5), 485-491.

Caffrey, C. R., Rohwer, A., Oellien, F., Marhöfer, R. J., Braschi, S., Oliveira, G., et al. (2009). A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, schistosoma mansoni. PLoS ONE, 4(2)

Camerer, E., Regard, J. B., Cornelissen, I., Srinivasan, Y., Duong, D. N., Palmer, D., et al. (2009). Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. Journal of Clinical Investigation, 119(7), 1871-1879.

Campbell, W. C., Conder, G. A., & Marchiondo, A. A. (2009). Future of the animal health industry at a time of food crisis. Veterinary Parasitology, 163(3), 188-195.

Card, A., Caldwell, C., Min, H., Lokchander, B., Xi, H., Sciabola, S., et al. (2009). High-throughput biochemical kinase selectivity assays: Panel development and screening applications. Journal of Biomolecular Screening, 14(1), 31-42.

Castellino, F. J., & Ploplis, V. A. (2009). The protein C pathway and pathologic processes. Journal of Thrombosis and Haemostasis, 7(SUPPL. 1), 140-145.

Chae, J. J., Aksentijevich, I., & Kastner, D. L. (2009). Advances in the understanding of familial mediterranean fever and possibilities for targeted therapy. British Journal of Haematology, 146(5), 467-478.

Chang, E., Congdon, E. E., Honson, N. S., Duff, K. E., & Kuret, J. (2009). Structure-activity relationship of cyanine tau aggregation inhibitors. Journal of Medicinal Chemistry, 52(11), 3539-3547.

Chen, C. -., & Reamer, R. A. (2009). A facile synthesis of N,3-disubstituted indoles and 3-hydroxyl indolines via an intramolecular SNAr of fluorinated amino alcohols. Tetrahedron Letters, 50(14), 1529-1532.

Chen, G., Shaw, M. H., Kim, Y. -., & Nuñez, G. (2009). NOD-like receptors: Role in innate immunity and inflammatory disease

Chu, Z., Andrade, J., Shupnik, M. A., & Moenter, S. M. (2009). Differential regulation of gonadotropin-releasing hormone neuron activity and membrane properties by acutely applied estradiol: Dependence on dose and estrogen receptor subtype. Journal of Neuroscience, 29(17), 5616-5627.

Clapham, K. M., Batsanov, A. S., Bryce, M. R., & Tarbit, B. (2009). Trifluoromethyl-substituted pyridyl- and pyrazolylboronic acids and esters: Synthesis and suzuki-miyaura cross-coupling reactions. Organic and Biomolecular Chemistry, 7(10), 2155-2161.

Clarke, D. L., Dakshinamurti, S., Larsson, A. -., Ward, J. E., & Yamasaki, A. (2009). Lipid metabolites as regulators of airway smooth muscle function. Pulmonary Pharmacology and Therapeutics, 22(5), 426-435.

Codocedo, J. F., Rodríguez, F. E., & Huidobro-Toro, J. P. (2009). Neurosteroids differentially modulate P2X4 ATP-gated channels through non-genomic interactions. Journal of Neurochemistry, 110(2), 734-744.

Coma, I., Clark, L., Diez, E., Harper, G., Herranz, J., Hofmann, G., et al. (2009). Process validation and screen reproducibility in high-throughput screening. Journal of Biomolecular Screening, 14(1), 66-76.

Conn, P. J., Jones, C. K., & Lindsley, C. W. (2009). Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders. Trends in Pharmacological Sciences, 30(3), 148-155.

Cornil, C. A. (2009). Rapid regulation of brain oestrogen synthesis: The behavioural roles of oestrogens and their fates. Journal of Neuroendocrinology, 21(3), 217-226.

Corona, G., Elia, C., Casetta, B., Diana, C., Rosalen, S., Bari, M., et al. (2009). A liquid chromatography-tandemmass spectrometry method for the simultaneous determination of exemestane and its metabolite 17-dihydroexemestane in human plasma. Journal of Mass Spectrometry, 44(6), 920-928.

Creton, R. (2009). Automated analysis of behavior in zebrafish larvae. Behavioural Brain Research, 203(1), 127-136.

D’Anglemont De Tassigny, X., Campagne, C., Steculorum, S., & Prevot, V. (2009). Estradiol induces physical association of neuronal nitric oxide synthase with NMDA receptor and promotes nitric oxide formation via estrogen receptor activation in primary neuronal cultures. Journal of Neurochemistry, 109(1), 214-224.

Damodaran, K., Nielsen, S. D., Geib, S. J., Zhang, W., Lu, Y., & Curran, D. P. (2009). Aryl-Csp3 bond rotation barriers of 2-aryl perhydropyrrolo[3,4- c]pyrrole-1,3-diones. Journal of Organic Chemistry, 74(15), 5481-5485.

Danot, O., Marquenet, E., Vidal-Ingigliardi, D., & Richet, E. (2009). Wheel of life, wheel of death: A mechanistic insight into signaling by STAND proteins. Structure, 17(2), 172-182.

de Azevedo Jr., W. F., Dias, R., Timmers, L. F. S. M., Pauli, I., Caceres, R. A., & Soares, M. B. P. (2009). Bioinformatics tools for screening of antiparasitic drugs. Current Drug Targets, 10(3), 232-239.

de Azevedo Jr., W. F., Caceres, R. A., Pauli, I., Timmers, L. F. S. M., Barcellos, G. B., Rocha, K. B., et al. (2009). Protein-drug interaction studies for development of drugs against plasmodium falciparum. Current Drug Targets, 10(3), 271-278.

de Kloe, G. E., Bailey, D., Leurs, R., & de Esch, I. J. P. (2009). Transforming fragments into candidates: Small becomes big in medicinal chemistry. Drug Discovery Today, 14(13-14), 630-646.

De Paoli, P. (2009). Institutional shared resources and translational cancer research. Journal of Translational Medicine, 7

De Wael, F., Jeanjot, P., Moens, C., Verbeuren, T., Cordi, A., Bouskela, E., et al. (2009). In vitro and in vivo studies of 6,8-(diaryl)imidazo[1,2-a]pyrazin-3(7H)-ones as new antioxidants. Bioorganic and Medicinal Chemistry, 17(13), 4336-4344.

Debotton, N., Giladi, O., Parnes, M., & Benita, S. (2009). Novel high-content paclitaxel palmitate nanospheres for improved cancer treatment. Journal of Drug Delivery Science and Technology, 19(4), 275-282.

Delomenède, M., Buchet, R., & Mebarek, S. (2009). Lansoprazole is an uncompetitive inhibitor of tissue-nonspecific alkaline phosphatase. Acta Biochimica Polonica, 56(2), 301-306.

Demian, D. J., Clugston, S. L., Foster, M. M., Rameh, L., Sarkes, D., Townson, S. A., et al. (2009). High-throughput, cell-free, liposome-based approach for assessing in vitro activity of lipid kinases. Journal of Biomolecular Screening, 14(7), 838-844.

Deshmukh, S. K., Mishra, P. D., Kulkarni-Almeida, A., Verekar, S., Sahoo, M. R., Periyasamy, G., et al. (2009). Anti-inflammatory and anticancer activity of ergoflavin isolated from an endophytic fungus. Chemistry and Biodiversity, 6(5), 784-789.

Diamond, M. S. (2009). Progress on the development of therapeutics against west nile virus. Antiviral Research, 83(3), 214-227.

Ding, X. -., Zhang, H. -., Qi, L., Zhao, B. -., Lian, S., Lv, H. -., et al. (2009). Synthesis of novel pyrazole carboxamide derivatives and discovery of modulators for apoptosis or autophagy in A549 lung cancer cells. Bioorganic and Medicinal Chemistry Letters, 19(18), 5325-5328.

Dissous, C., Ahier, A., & Long, T. (2009). A new promising drug against schistosomiasis. [Un nouvel espoir dans le traitement de la schistosomiase] Medecine/Sciences, 25(1), 24-26.

Doghman, M., & Lalli, E. (2009). A matter of dosage: SF-1 in adrenocortical development and cancer. Annales d’Endocrinologie, 70(3), 148-152.

dos Santos Filho, J. M., Leite, A. C. L., Oliveira, B. G. d., Moreira, D. R. M., Lima, M. S., Soares, M. B. P., et al. (2009). Design, synthesis and cruzain docking of 3-(4-substituted-aryl)-1,2,4-oxadiazole-N-acylhydrazones as anti-trypanosoma cruzi agents. Bioorganic and Medicinal Chemistry, 17(18), 6682-6691.

Drennan, M. B., Elewaut, D., & Hogquist, K. A. (2009). Thymic emigration: Sphingosine-1-phosphate receptor-1-dependent models and beyond. European Journal of Immunology, 39(4), 925-930.

Duerfeldt, A. S., Brandt, G. E. L., & Blagg, B. S. J. (2009). Design, synthesis, and biological evaluation of conformationally constrained cis-amide HSP90 inhibitors. Organic Letters, 11(11), 2353-2356.

Dunworth, W. P., & Caron, K. M. (2009). G protein-coupled receptors as potential drug targets for lymphangiogenesis and lymphatic vascular diseases. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(5), 650-656.

Eglen, R. M., & Reisine, T. (2009). The current status of drug discovery against the human kinome. Assay and Drug Development Technologies, 7(1), 22-43.

Ekonomiuk, D., Su, X. -., Ozawa, K., Bodenreider, C., Siew, P. L., Otting, G., et al. (2009). Flaviviral protease inhibitors identified by fragment-based library docking into a structure generated by molecular dynamics. Journal of Medicinal Chemistry, 52(15), 4860-4868.

Ekonomiuk, D., Su, X. -., Ozawa, K., Bodenreider, C., Lim, S. P., Yin, Z., et al. (2009). Discovery of a non-peptidic inhibitor of west nile virus NS3 protease by high-throughput docking. PLoS Neglected Tropical Diseases, 3(1)

Ellmann, S., Sticht, H., Thiel, F., Beckmann, M. W., Strick, R., & Strissel, P. L. (2009). Estrogen and progesterone receptors: From molecular structures to clinical targets. Cellular and Molecular Life Sciences, 66(15), 2405-2426.

Emerson, C. H. (2009). Circulating thyroid stimulating hormones: Why, when, and what to measure. Thyroid, 19(1), 1-4.

Entzeroth, M., Flotow, H., & Condron, P. (2009). Overview of high-throughput screening. Current Protocols in Pharmacology, (SUPPL. 44), 9.4.1-9.4.27.

Ezgimen, M. D., Mueller, N. H., Teramoto, T., & Padmanabhan, R. (2009). Effects of detergents on the west nile virus protease activity. Bioorganic and Medicinal Chemistry, 17(9), 3278-3282.

Fehrenbacher, J. C., LoVerme, J., Clarke, W., Hargreaves, K. M., Piomelli, D., & Taylor, B. K. (2009). Rapid pain modulation with nuclear receptor ligands. Brain Research Reviews, 60(1), 114-124.

Fenton, R. A. (2009). Essential role of vasopressin-regulated urea transport processes in the mammalian kidney. Pflugers Archiv European Journal of Physiology, 458(1), 169-177.

Fisher, N., Warman, A. J., Ward, S. A., & Biagini, G. A. (2009). Chapter 17 type II NADH: Quinone oxidoreductases of plasmodium falciparum and mycobacterium tuberculosis. kinetic and high-throughput assays

Fix-Stenzel, S. R., Hayes, M. E., Zhang, X., Wallace, G. A., Grongsaard, P., Schaffter, L. M., et al. (2009). A stereoselective and scalable synthesis of a conformationally constrained S1P1 agonist. Tetrahedron Letters, 50(28), 4081-4083.

Foley, T. L., & Burkart, M. D. (2009). A homogeneous resonance energy transfer assay for phosphopantetheinyl transferase. Analytical Biochemistry, 394(1), 39-47.

Foss Jr., F. W., Mathews, T. P., Kharel, Y., Kennedy, P. C., Snyder, A. H., Davis, M. D., et al. (2009). Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs. Bioorganic and Medicinal Chemistry, 17(16), 6123-6136.

Fowler, R. A., Adhikari, N. K. J., Scales, D. C., Lee, W. L., & Rubenfeld, G. D. (2009). Update in critical care 2008. American Journal of Respiratory and Critical Care Medicine, 179(9), 743-758.

Fox, E. M., Andrade, J., & Shupnik, M. A. (2009). Novel actions of estrogen to promote proliferation: Integration of cytoplasmic and nuclear pathways. Steroids, 74(7), 622-627.

Franchi, L., Eigenbrod, T., Muñoz-Planillo, R., & Nuñez, G. (2009). The inflammasome: A caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nature Immunology, 10(3), 241-247.

Franchi, L., Warner, N., Viani, K., & Nuñez, G. (2009). Function of nod-like receptors in microbial recognition and host defense. Immunological Reviews, 227(1), 106-128.

Fraser, I. D. C., & Germain, R. N. (2009). Navigating the network: Signaling cross-talk in hematopoietic cells. Nature Immunology, 10(4), 327-331.

Gao, J., Sidhu, S. S., & Wells, J. A. (2009). Two-state selection of conformation-specific antibodies. Proceedings of the National Academy of Sciences of the United States of America, 106(9), 3071-3076.

Gasparri, F. (2009). An overview of cell phenotypes in HCS: Limitations and advantages. Expert Opinion on Drug Discovery, 4(6), 643-657.

Gavrilyuk, J. I., Wuellner, U., Salahuddin, S., Goswami, R. K., Sinha, S. C., & Barbas III, C. F. (2009). An efficient chemical approach to bispecific antibodies and antibodies of high valency. Bioorganic and Medicinal Chemistry Letters, 19(14), 3716-3720.

George, S., Kumbhakar, M., Singh, P. K., Ganguly, R., Nath, S., & Pal, H. (2009). Fluorescence spectroscopic investigation to identify the micelle to gel transition of aqueous triblock copolymer solutions. Journal of Physical Chemistry B, 113(15), 5117-5127.

Gerber, A. N., Masuno, K., & Diamond, M. I. (2009). Discovery of selective glucocorticoid receptor modulators by multiplexed reporter screening. Proceedings of the National Academy of Sciences of the United States of America, 106(12), 4929-4934.

Gil, C., & Bräse, S. (2009). Solid-phase synthesis of biologically active benzoannelated nitrogen heterocycles: An update. Journal of Combinatorial Chemistry, 11(2), 175-197.

Gilbert, D. F., Wilson, J. C., Nink, V., Lynch, J. W., & Osborne, G. W. (2009). Multiplexed labeling of viable cells for high-throughput analysis of glycine receptor function using flow cytometry. Cytometry Part A, 75(5), 440-449.

Gossens, K., Naus, S., Corbel, S. Y., Lin, S., Rossi, F. M. V., Kast, J., et al. (2009). Thymic progenitor homing and lymphocyte homeostasis are linked via s1p-controlled expression of thymic p-selectin/ccl25. Journal of Experimental Medicine, 206(4), 761-778.

Graf, C., Rovina, P., & Bornancin, F. (2009). A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides. Analytical Biochemistry, 384(1), 166-169.

Grigorova, I. L., Schwab, S. R., Phan, T. G., Pham, T. H. M., Okada, T., & Cyster, J. G. (2009). Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells. Nature Immunology, 10(1), 58-65.

Guise, T. A., & Brown, S. A. (2009). Cancer treatment-related bone disease. Critical Reviews in Eukaryotic Gene Expression, 19(1), 47-60.

Habig, M., Blechschmidt, A., Dressler, S., Hess, B., Patel, V., Billich, A., et al. (2009). Efficient elimination of nonstoichiometric enzyme inhibitors from HTS hit lists. Journal of Biomolecular Screening, 14(6), 679-689.

Hakamata, W., Kurihara, M., Okuda, H., Nishio, T., & Oku, T. (2009). Design and screening strategies for α-glucosidase inhibitors based on enzymological information. Current Topics in Medicinal Chemistry, 9(1), 3-12.

Hammer, M. M., Kotecha, N., Irish, J. M., Nolan, G. P., & Krutzik, P. O. (2009). WebFlow: A software package for high-throughput analysis of flow cytometry data. Assay and Drug Development Technologies, 7(1), 44-55.

Hammond, R., Mauk, R., Ninaci, D., Nelson, D., & Gibbs, R. B. (2009). Chronic treatment with estrogen receptor agonists restores acquisition of a spatial learning task in young ovariectomized rats. Hormones and Behavior, 56(3), 309-314.

Han, G., Ma, H., Chintala, R., Fulton, D. J. R., Barman, S. A., & White, R. E. (2009). Essential role of the 90-kilodalton heat shock protein in mediating nongenomic estrogen signaling in coronary artery smooth muscle. Journal of Pharmacology and Experimental Therapeutics, 329(3), 850-855.

Hansch, C., & Verma, R. P. (2009). A QSAR study for the cytotoxic activities of taxoids against macrophage (MΦ)-like cells. European Journal of Medicinal Chemistry, 44(1), 274-279.

Hara, T., Hirasawa, A., Sun, Q., Sadakane, K., Itsubo, C., Iga, T., et al. (2009). Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn-Schmiedeberg’s Archives of Pharmacology, 380(3), 247-255.

Harland, L., & Gaulton, A. (2009). Drug target central. Expert Opinion on Drug Discovery, 4(8), 857-872.

Hartung, H. -. (2009). New oral therapies may offer improved treatment options for patients with multiple sclerosis. Current Opinion in Neurology, 22(SUPPL. 1), S10-S14.

Hatae, J., Takami, N., Lin, H., Honda, A., & Inoue, R. (2009). 17β-estradiol-induced enhancement of estrogen receptor biosynthesis via MAPK pathway in mouse skeletal muscle myoblasts. Journal of Physiological Sciences, 59(3), 181-190.

Haynes, M. K., Strouse, J. J., Waller, A., Leitao, A., Curpan, R. F., Bologa, C., et al. (2009). Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt® high-throughput flow cytometry system. Journal of Biomolecular Screening, 14(6), 596-609.

He, M. -., Liu, L., Ge, W., Shaw, P. -., Jiang, R., Wu, L. -., et al. (2009). Antiangiogenic activity of tripterygium wilfordii and its terpenoids. Journal of Ethnopharmacology, 121(1), 61-68.

Hegedus, C., Szakács, G., Homolya, L., Orbán, T. I., Telbisz, Á, Jani, M., et al. (2009). Ins and outs of the ABCG2 multidrug transporter: An update on in vitro functional assays. Advanced Drug Delivery Reviews, 61(1), 47-56.

Herbst, K. J., Allen, M. D., & Zhang, J. (2009). The cAMP-dependent protein kinase inhibitor H-89 attenuates the bioluminescence signal produced by renilla luciferase. PLoS ONE, 4(5)

Herroeder, S., Reichardt, P., Sassmann, A., Zimmermann, B., Jaeneke, D., Hoeckner, J., et al. (2009). Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility. Immunity, 30(5), 708-720.

Himanen, J. P., Goldgur, Y., Miao, H., Myshkin, E., Guo, H., Buck, M., et al. (2009). Ligand recognition by A-class eph receptors: Crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex. EMBO Reports, 10(7), 722-728.

Hiss, D. C., & Gabriels, G. A. (2009). Implications of endoplasmic reticulum stress, the unfolded protein response and apoptosis for molecular cancer therapy. part I: Targeting p53, Mdm2, GADD153/CHOP, GRP78/BiP and heat shock proteins. Expert Opinion on Drug Discovery, 4(8), 799-821.

Hollins, B., Kuravi, S., Digby, G. J., & Lambert, N. A. (2009). The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers. Cellular Signalling, 21(6), 1015-1021.

Homma, K., Katagiri, K., Nishitoh, H., & Ichijo, H. (2009). Targeting ASK1 in ER stress-related neurodegenerative diseases. Expert Opinion on Therapeutic Targets, 13(6), 653-664.

Huang, X., Cao, J., & Huang, J. (2009). Solid-phase synthesis of benzofused tricycles based on benzimidazole from resin-bound 3-(2-aminophenylamino)-2-seleno-ester. Journal of Combinatorial Chemistry, 11(4), 515-518.

Hutter, M. C. (2009). In silico prediction of drug properties. Current Medicinal Chemistry, 16(2), 189-202.

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Rohrer, S. G., & Baumann, K. (2009). Maximum unbiased validation (MUV) data sets for virtual screening based on PubChem bioactivity data. Journal of Chemical Information and Modeling, 49(2), 169-184.

Rojo, F., González-Navarrete, I., Bragado, R., Dalmases, A., Menéndez, S., Cortes-Sempere, M., et al. (2009). Mitogen-activated protein kinase phosphatase-1 in human breast cancer independently predicts prognosis and is repressed by doxorubicin. Clinical Cancer Research, 15(10), 3530-3539.

Romero-Sandoval, E. A., Horvath, R., Landry, R. P., & DeLeo, J. A. (2009). Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation. Molecular Pain, 5

Rosen, H., Gonzalez-Cabrera, P. J., Sanna, M. G., & Brown, S. (2009). Sphingosine 1-phosphate receptor signaling

Rosén, J., Lövgren, A., Kogej, T., Muresan, S., Gottfries, J., & Backlund, A. (2009). ChemGPS-NPWeb: Chemical space navigation online. Journal of Computer-Aided Molecular Design, 23(4), 253-259.

Rossi, K. A., Nayeem, A., Weigelt, C. A., & Krystek Jr., S. R. (2009). Closing the side-chain gap in protein loop modeling. Journal of Computer-Aided Molecular Design, 23(7), 411-418.

Saha, S., Qi, J., Wang, S., Wang, M., Li, X., Kim, Y. -., et al. (2009). PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation. Cell Host and Microbe, 5(2), 137-150.

Sakamoto, S., Kabe, Y., Hatakeyama, M., Yamaguchi, Y., & Handa, H. (2009). Development and application of high-performance affinity beads: Toward chemical biology and drug discovery. Chemical Record, 9(1), 66-85.

Sampath, A., & Padmanabhan, R. (2009). Molecular targets for flavivirus drug discovery. Antiviral Research, 81(1), 6-15.

Sánchez, G., de Oliveira Alvares, L., Oberholzer, M. V., Genro, B., Quillfeldt, J., Costa da Costa, J., et al. (2009). M4 muscarinic receptors are involved in modulation of neurotransmission at synapses of schaffer collaterals on CA1 hippocampal neurons in rats. Journal of Neuroscience Research, 87(3), 691-700.

Sánchez-Ollé, G., Duque, J., Egido-Gabás, M., Casas, J., Lluch, M., Chabás, A., et al. (2009). Promising results of the chaperone effect caused by iminosugars and aminocyclitol derivatives on mutant glucocerebrosidases causing gaucher disease. Blood Cells, Molecules, and Diseases, 42(2), 159-166.

SÁnchez-Pedregal, V. M., & Griesinger, C. (2009). The tubulin binding mode of MT stabilizing and destabilizing agents studied by NMR

Sancho, A. G., Wang, X., Sui, B., & Curran, D. P. (2009). Comparison of the relative reactivities of the triisopropylsilyl group with two fluorous analogs. Advanced Synthesis and Catalysis, 351(7-8), 1035-1040.

Satoh, W., Takahashi, S., Sassa, F., Fukuda, J., & Suzuki, H. (2009). On-chip culturing of hepatocytes and monitoring their ammonia metabolism. Lab on a Chip – Miniaturisation for Chemistry and Biology, 9(1), 35-37.

Sattler, K., & Levkau, B. (2009). Sphingosine-1-phosphate as a mediator of high-density lipoprotein effects in cardiovascular protection. Cardiovascular Research, 82(2), 201-211.

Scheiber, J., Chen, B., Milik, M., Sukuru, S. C. K., Bender, A., Mikhailov, D., et al. (2009). Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis. Journal of Chemical Information and Modeling, 49(2), 308-317.

Schlueter, P. J., & Peterson, R. T. (2009). Systematizing serendipity for cardiovascular drug discovery. Circulation, 120(3), 255-263.

Schmitz, C. H. J., Rowat, A. C., Köster, S., & Weitz, D. A. (2009). Dropspots: A picoliter array in a microfluidic device. Lab on a Chip – Miniaturisation for Chemistry and Biology, 9(1), 44-49.

Schneider, G., Hartenfeller, M., Reutlinger, M., Tanrikulu, Y., Proschak, E., & Schneider, P. (2009). Voyages to the (un)known: Adaptive design of bioactive compounds. Trends in Biotechnology, 27(1), 18-26.

Schulz, C., Von Andrian, U., & Massberg, S. (2009). Trafficking of murine hematopoietic stem and progenitor cells in health and vascular disease. Microcirculation, 16(6), 497-507.

Schwede, T., Sali, A., Honig, B., Levitt, M., Berman, H. M., Jones, D., et al. (2009). Outcome of a workshop on applications of protein models in biomedical research. Structure, 17(2), 151-159.

Schwerte, T. (2009). Cardio-respiratory control during early development in the model animal zebrafish. Acta Histochemica, 111(3), 230-243.

Scott, W. L., Alsina, J., Audu, C. O., Babaev, E., Cook, L., Dage, J. L., et al. (2009). Distributed drug discovery, part 2: Global rehearsal of alkylating agents for the synthesis of resin-bound unnatural amino acids and virtual D3 catalog construction. Journal of Combinatorial Chemistry, 11(1), 14-33.

Scott, W. L., & O’Donnell, M. J. (2009). Distributed drug discovery, part 1: Linking aeademia and combinatorial chemistry to find drug leads for developing world diseases. Journal of Combinatorial Chemistry, 11(1), 3-13.

Sergienko, E., Su, Y., Chan, X., Brown, B., Hurder, A., Narisawa, S., et al. (2009). Identification and characterization of novel tissue-nonspecific alkaline phosphatase inhibitors with diverse modes of action. Journal of Biomolecular Screening, 14(7), 824-837.

Servent, D., & Fruchart-Gaillard, C. (2009). Muscarinic toxins: Tools for the study of the pharmacological and functional properties of muscarinic receptors. Journal of Neurochemistry, 109(5), 1193-1202.

Severin, A., Joseph, R. E., Boyken, S., Fulton, D. B., & Andreotti, A. H. (2009). Proline isomerization preorganizes the itk SH2 domain for binding to the itk SH3 domain. Journal of Molecular Biology, 387(3), 726-743.

Shaw, A. S., & Filbert, E. L. (2009). Scaffold proteins and immune-cell signalling. Nature Reviews Immunology, 9(1), 47-56.

Shaw, J. T. (2009). Naturally diverse: Highlights in versatile synthetic methods enabling target- and diversity-oriented synthesis. Natural Product Reports, 26(1), 11-26.

Shimizu, T. (2009). Lipid mediators in health and disease: Enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation

Silverman, G. A., Luke, C. J., Bhatia, S. R., Long, O. S., Vetica, A. C., Perlmutter, D. H., et al. (2009). Modeling molecular and cellular aspects of human disease using the nematode caenorhabditis elegans. Pediatric Research, 65(1), 10-18.

Singh, N., Guha, R., Giulianotti, M. A., Pinilla, C., Houghten, R. A., & Medina-Franco, J. L. (2009). Chemoinformatic analysis of combinatorial libraries, drugs, natural products, and molecular libraries small molecule repository. Journal of Chemical Information and Modeling, 49(4), 1010-1024.

Sinha, R. K., Park, C., Hwang, I. -., Davis, M. D., & Kehrl, J. H. (2009). B lymphocytes exit lymph nodes through cortical lymphatic sinusoids by a mechanism independent of sphingosine-1-phosphate-mediated chemotaxis. Immunity, 30(3), 434-446.

Slack, M., Winkler, D., Krämer, J., & Hesterkamp, T. (2009). A multiplexed approach to hit finding. Current Opinion in Drug Discovery and Development, 12(3), 351-357.

Slysz, G. W., Baker, C. A. H., Bozsa, B. M., Dang, A., Percy, A. J., Bennett, M., et al. (2009). Hydra: Software for tailored processing of H/D exchange data from MS or tandem MS analyses. BMC Bioinformatics, 10

Smalter, A., Huan, J., & Lushington, G. (2009). Graph wavelet alignment kernels for drug virtual screening. Journal of Bioinformatics and Computational Biology, 7(3), 473-497.

Smiley, D. A., & Khalil, R. A. (2009). Estrogenic compounds, estrogen receptors and vascular cell signaling in the aging blood vessels. Current Medicinal Chemistry, 16(15), 1863-1887.

Smith, P. J., Khan, I. A., & Errington, R. J. (2009). Cytomics and cellular informatics – coping with asymmetry and heterogeneity in biological systems. Drug Discovery Today, 14(5-6), 271-277.

Smits, H. L. (2009). Prospects for the control of neglected tropical diseases by mass drug administration. Expert Review of Anti-Infective Therapy, 7(1), 37-56.

Sölder, E., Kremser, C., Rohr, I., Hutzler, P., & Debbage, P. (2009). Molecular mapping deep within a living human organ: Analysis of microvessel function on the timescale of seconds and with sub-micrometre spatial resolutio. Histochemistry and Cell Biology, 131(5), 537-551.

Solinas, R., DiCesare, J. C., & Baures, P. W. (2009). Parallel synthesis of a library of symmetrically- and dissymmetrically- disubstituted imidazole-4,5-dicarboxamides bearing amino acid esters. Molecules, 14(1), 352-363.

Soulère, L. (2009). Toward docking-based virtual screening for discovering antitubulin agents by targeting taxane and colchicine binding sites. ChemMedChem, 4(2), 161-163.

Spichty, M., Taly, A., Hagn, F., Kessler, H., Barluenga, S., Winssinger, N., et al. (2009). The HSP90 binding mode of a radicicol-like E-oxime determined by docking, binding free energy estimations, and NMR 15N chemical shifts. Biophysical Chemistry, 143(3), 111-123.

Stocks, M. J., Wilden, G. R. H., Pairaudeau, G., Perry, M. W. D., Steele, J., & Stonehouse, J. P. (2009). A practical method for targeted library design balancing lead-like properties with diversity. ChemMedChem, 4(5), 800-808.

Su, X. -., Ozawa, K., Yagi, H., Lim, S. P., Wen, D., Ekonomiuk, D., et al. (2009). NMR study of complexes between low molecular mass inhibitors and the west nile virus NS2B-NS3 protease. FEBS Journal, 276(15), 4244-4255.

Sukocheva, O., Wadham, C., & Xia, P. (2009). Role of sphingolipids in the cytoplasmic signaling of estrogens. Steroids, 74(7), 562-567.

Sukuru, S. C. K., Jenkins, J. L., Beckwith, R. E. J., Scheiber, J., Bender, A., Mikhailov, D., et al. (2009). Plate-based diversity selection based on empirical HTS data to enhance the number of hits and their chemical diversity. Journal of Biomolecular Screening, 14(6), 690-699.

Sweeney, J., Kouttab, N., & Kurtis, J. (2009). Stored red blood cell supernatant facilitates thrombin generation. Transfusion, 49(8), 1569-1579.

Takken, F. L. W., & Tameling, W. I. L. (2009). To nibble at plant resistance proteins. Science, 324(5928), 744-746.

Tan, H. Y., Ng, T. W., & Liew, O. W. (2009). Filterless fluorometry with enhanced sensitivity. Journal of Fluorescence, 19(2), 375-379.

Tao, R., Hoover, H. E., Zhang, J., Honbo, N., Alano, C. C., & Karliner, J. S. (2009). Cardiomyocyte S1P1 receptor-mediated extracellular signal-related kinase signaling and desensitization. Journal of Cardiovascular Pharmacology, 53(6), 486-494.

Terasawa, E., Noel, S. D., & Keen, K. L. (2009). Rapid action of oestrogen in luteinising hormone-releasing hormone neurones: The role of GPR30. Journal of Neuroendocrinology, 21(4), 316-321.

Thammacharoen, S., Geary, N., Lutz, T. A., Ogawa, S., & Asarian, L. (2009). Divergent effects of estradiol and the estrogen receptor-α agonist PPT on eating and activation of PVN CRH neurons in ovariectomized rats and mice. Brain Research, 1268(C), 88-96.

Thorpe, K. L., Maack, G., Benstead, R., & Tyler, C. R. (2009). Estrogenic wastewater treatment works effluents reduce egg production in fish. Environmental Science and Technology, 43(8), 2976-2982.

Tietze, L. F., & Krewer, B. (2009). Novel analogues of CC-1065 and the duocarmycins for the use in targeted tumour therapies. Anti-Cancer Agents in Medicinal Chemistry, 9(3), 304-325.

Titus, S. A., Beacham, D., Shahane, S. A., Southall, N., Xia, M., Huang, R., et al. (2009). A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel. Analytical Biochemistry, 394(1), 30-38.

Tomašić, T., & Mašič, L. P. (2009). Rhodanine as a privileged scaffold in drug discovery. Current Medicinal Chemistry, 16(13), 1596-1629.

Tomlinson, S. M., Malmstrom, R. D., & Watowich, S. J. (2009). New approaches to structure-based discovery of dengue protease inhibitors. Infectious Disorders – Drug Targets, 9(3), 327-343.

Top, S., Thibaudeau, C., Vessières, A., Brulé, E., Le Bideau, F., Joerger, J. -., et al. (2009). Synthesis and structure activity relationship of organometallic steroidal androgen derivatives. Organometallics, 28(5), 1414-1424.

Tu, G., Hu, D., Yang, G., & Yu, T. (2009). The correlation between GPR30 and clinicopathologic variables in breast carcinomas. Technology in Cancer Research and Treatment, 8(3), 231-234.

Turk, S., Kovač, A., Boniface, A., Bostock, J. M., Chopra, I., Blanot, D., et al. (2009). Discovery of new inhibitors of the bacterial peptidoglycan biosynthesis enzymes MurD and MurF by structure-based virtual screening. Bioorganic and Medicinal Chemistry, 17(5), 1884-1889.

Van Den Enden, E. (2009). Pharmacotherapy of helminth infection. Expert Opinion on Pharmacotherapy, 10(3), 435-451.

Villar, H. O., & Hansen, M. R. (2009). Mining and visualizing the chemical content of large databases. Current Opinion in Drug Discovery and Development, 12(3), 367-375.

Vincent, J. -., Artigas, A., Petersen, L. C., & Meyer, C. (2009). A multicenter, randomized, double-blind, placebo-controlled, dose-escalation trial assessing safety and efficacy of active site inactivated recombinant factor VIIa in subjects with acute lung injury or acute respiratory distress syndrome. Critical Care Medicine, 37(6), 1874-1880.

Vogel, P., Donoviel, M. S., Read, R., Hansen, G. M., Hazlewood, J., Anderson, S. J., et al. (2009). Incomplete inhibition of sphingosine 1-phosphate lyase modulates imune system function yet prevents early lethality and non-lymphoid lesions. PLoS ONE, 4(1)

Vogt, A., Cholewinski, A., Shen, X., Nelson, S. G., Lazo, J. S., Tsang, M., et al. (2009). Automated image-based phenotypic analysis in zebrafish embryos. Developmental Dynamics, 238(3), 656-663.

Wagner, R. N., Proell, M., Kufer, T. A., & Schwarzenbacher, R. (2009). Evaluation of nod-like receptor (NLR) effector domain interactions. PLoS ONE, 4(4)

Wallace, G. A., Gordon, T. D., Hayes, M. E., Konopacki, D. B., Fix-Stenzel, S. R., Zhang, X., et al. (2009). Scalable synthesis and isolation of the four stereoisomers of methyl 1-amino-3-(4-bromophenyl)cyclopentanecarboxylate, useful intermediates for the synthesis of S1P1 receptor agonists. Journal of Organic Chemistry, 74(13), 4886-4889.

Walser, M., Pellaux, R., Meyer, A., Bechtold, M., Vanderschuren, H., Reinhardt, R., et al. (2009). Novel method for high-throughput colony PCR screening in nanoliter-reactors. Nucleic Acids Research, 37(8)

Wang, X. -., Li, Q., Wu, J. -., & Tu, S. -. (2009). Efficient method for the synthesis of pyranoquinoline, thiopyranoquinoline, thienoquinoline, and naphtho[2,7]naphthyridine derivatives catalyzed by iodine. Journal of Combinatorial Chemistry, 11(3), 433-437.

Wang, Y., Xiao, J., Suzek, T. O., Zhang, J., Wang, J., & Bryant, S. H. (2009). PubChem: A public information system for analyzing bioactivities of small molecules. Nucleic Acids Research, 37(SUPPL. 2), W623-W633.

Weigert, A., Weis, N., & Brüne, B. (2009). Regulation of macrophage function by sphingosine-1-phosphate. Immunobiology, 214(9-10), 748-760.

Weiler, H., & Kerschen, E. (2009). Modulation of sepsis outcome with variants of activated protein C. Journal of Thrombosis and Haemostasis, 7(SUPPL. 1), 127-131.

Weill, N., & Rognan, D. (2009). Development and validation of a novel protein-ligand fingerprint to mine chemogenomic space: Application to G protein-coupled receptors and their ligands. Journal of Chemical Information and Modeling, 49(4), 1049-1062.

Wellendorph, P., Johansen, L. D., & Bräuner-Osborne, H. (2009). Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients. Molecular Pharmacology, 76(3), 453-465.

Wetzel, S., Klein, K., Renner, S., Rauh, D., Oprea, T. I., Mutzel, P., et al. (2009). Interactive exploration of chemical space with scaffold hunter. Nature Chemical Biology, 5(8), 581-583.

Wheeler, G. N., & Brändli, A. W. (2009). Simple vertebrate models for chemical genetics and drug discovery screens: Lessons from zebrafish and xenopus. Developmental Dynamics, 238(6), 1287-1308.

Williams, N. K., Bamert, R. S., Patel, O., Wang, C., Walden, P. M., Wilks, A. F., et al. (2009). Dissecting specificity in the janus kinases: The structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains. Journal of Molecular Biology, 387(1), 219-232.

Windahl, S. H., Andersson, N., Chagin, A. S., Mårtensson, U. E. A., Carlsten, H., Olde, B., et al. (2009). The role of the G protein-coupled receptor GPR30 in the effects of estrogen in ovariectomized mice. American Journal of Physiology – Endocrinology and Metabolism, 296(3), E490-E496.

Wu, Y. J., Chen, D. W., Liu, J. L., Zhang, J. H., Luo, H. S., & Cui, S. (2009). Estradiol promotes pituitary cell proliferation and gonadotroph differentiation at different doses and with different mechanisms in chick embryo. Steroids, 74(4-5), 441-448.

Xu, J., Ji, Y., Zhang, X., Drake, M., & Esmon, C. T. (2009). Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccaride-induced septic shock. Journal of Thrombosis and Haemostasis, 7(5), 851-856.

Xu, Y., Su, Y. -., & Yao, Y. -. (2009). Advances in research on pharmacokinetic models of high-throughput screening for drug discovery. Pharmaceutical Care and Research, 9(3), 218-221.

Xu, Y., & Li, X. -. (2009). Multi-target therapeutics and new drug discovery. Yaoxue Xuebao, 44(3), 226-230.

Yang, L., Ho, N. Y., Alshut, R., Legradi, J., Weiss, C., Reischl, M., et al. (2009). Zebrafish embryos as models for embryotoxic and teratological effects of chemicals. Reproductive Toxicology, 28(2), 245-253.

Yarmush, M. L., & King, K. R. (2009). Living-cell microarrays

Yaziji, V., Coelho, A., Maatougui, A. E., Brea, J., Loza, M. I., Garcia-Mera, X., et al. (2009). Divergent solution-phase synthesis of diarylpyrimidine libraries as selective A3 adenosine receptor antagonists. Journal of Combinatorial Chemistry, 11(4), 519-522.

Yet, L. (2009). Chapter 5.4: Five-membered ring systems: With more than one N atom

Yi, C. H., & Yuan, J. (2009). The jekyll and hyde functions of caspases. Developmental Cell, 16(1), 21-34.

Yonesu, K., Ohnuki, T., Ono, Y., Takatsu, T., & Nara, F. (2009). Ascotricins A and B, novel antagonists of sphingosine-1-phosphate receptor 1 from ascotricha chartarum berk. SANK 14186. Journal of Antibiotics, 62(7), 359-364.

Yonesu, K., Kawase, Y., Inoue, T., Takagi, N., Tsuchida, J., Takuwa, Y., et al. (2009). Involvement of sphingosine-1-phosphate and S1P1 in angiogenesis: Analyses using a new S1P1 antagonist of non-sphingosine-1-phosphate analog. Biochemical Pharmacology, 77(6), 1011-1020.

Yu, L., Mohanram, V., Simonson, O. E., Smith, C. I. E., Spetz, A. -., & Mohamed, A. J. (2009). Proteasome inhibitors block HIV-1 replication by affecting both cellular and viral targets. Biochemical and Biophysical Research Communications, 385(1), 100-105.

Yuan, M. -., Shuai, Q., Wang, L., Li, X. -., & Yu, R. -. (2009). 5-bromo-1-methyl-indolin-2-one. Acta Crystallographica Section E: Structure Reports Online, 65(7)

Zallocchi, M., Meehan, D. T., Delimont, D., Askew, C., Garige, S., Gratton, M. A., et al. (2009). Localization and expression of clarin-1, the Clrn1 gene product, in auditory hair cells and photoreceptors. Hearing Research, 255(1-2), 109-120.

Zambianchi, M., Di Maria, F., Cazzato, A., Gigli, G., Piacenza, M., Della Sala, F., et al. (2009). Microwave-assisted synthesis of thiophene fluorophores, labeling and multilabeling of monoclonal antibodies, and long lasting staining of fixed cells. Journal of the American Chemical Society, 131(31), 10892-10900.

Zaragoza-Sundqvist, M., Eriksson, H., Rohman, M., & Greasley, P. J. (2009). High-quality cost-effective compound management support for HTS. Journal of Biomolecular Screening, 14(5), 509-514.

Zhang, C. -., Xiao, S. -., Utzinger, J., Chollet, J., Keiser, J., & Tanner, M. (2009). Histopathological changes in adult schistosoma japonicum harbored in mice treated with a single dose of mefloquine. Parasitology Research, 104(6), 1407-1416.

Zhang, J., Sattler, M., Tonon, G., Grabher, C., Lababidi, S., Zimmerhackl, A., et al. (2009). Targeting angiogenesis via a c-Myc/hypoxia-inducible factor-1α- dependent pathway in multiple myeloma. Cancer Research, 69(12), 5082-5090.

Zhang, Y., Byun, Y., Ren, Y. R., Liu, J. O., Laterra, J., & Pomper, M. G. (2009). Identification of inhibitors of ABCG2 by a bioluminescence imaging-based high-throughput assay. Cancer Research, 69(14), 5867-5875.

Zhang, Z., Zhang, Z. -., Fauser, U., & Schluesener, H. J. (2009). Distribution of Foxp3+ T-regulatory cells in experimental autoimmune neuritis rats. Experimental Neurology, 216(1), 75-82.

Zhao, C. -., Deng, Q. -., Zhang, D. -., Cai, W. -., & Zhang, J. -. (2009). Developmental profile and subcellular localization of the non-genomic membranous estrogen receptor GPR30 in the hippocampus of postnatal female rats. Progress in Biochemistry and Biophysics, 36(1), 103-107.

Zhu, H., Ye, L., Richard, A., Golbraikh, A., Wright, F. A., Rusyn, I., et al. (2009). A novel two-step hierarchical quantitative structure-activity relationship modeling work flow for predicting acute toxicity of chemicals in rodents. Environmental Health Perspectives, 117(8), 1257-1264.

2008

Abdul-Ghani, R., Loutfy, N., Sahn, A. E., & Hassan, A. (2009). Current chemotherapy arsenal for schistosomiasis mansoni: Alternatives and challenges. Parasitology Research, 104(5), 955-965.

Abdul-Ghani, R. A., Loutfy, N., & Hassan, A. (2009). Experimentally promising antischistosomal drugs: A review of some drug candidates not reaching the clinical use. Parasitology Research, 105(4), 899-906.

Abulafia, D. P., De Rivero Vaccari, J. P., Lozano, J. D., Lotocki, G., Keane, R. W., & Dietrich, W. D. (2009). Inhibition of the inflammasome complex reduces the inflammatory response after thromboembolic stroke in mice. Journal of Cerebral Blood Flow and Metabolism, 29(3), 534-544.

Allgeier, S. H., Vezina, C. M., Lin, T. -., Moore, R. W., Silverstone, A. E., Mukai, M., et al. (2009). Estrogen signaling is not required for prostatic bud patterning or for its disruption by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology and Applied Pharmacology, 239(1), 80-86.

Ananthan, S., Zhang, W., & Hobrath, J. V. (2009). Recent advances in structure-based virtual screening of G-protein coupled receptors. AAPS Journal, 11(1), 178-185.

Andersen, M. E., & Krewski, D. (2009). Toxicity testing in the 21st century: Bringing the vision to life. Toxicological Sciences, 107(2), 324-330.

Angelopoulos, N., Hadjiprocopis, A., & Walkinshaw, M. D. (2009). Bayesian model averaging for ligand discovery. Journal of Chemical Information and Modeling, 49(6), 1547-1557.

Antony, J., Kellershohn, K., Mohr-Andrä, M., Kebig, A., Prilla, S., Muth, M., et al. (2009). Dualsteric GPCR targeting: A novel route to binding and signaling pathway selectivity. FASEB Journal, 23(2), 442-450.

Arkin, M. R., & Whitty, A. (2009). The road less traveled: Modulating signal transduction enzymes by inhibiting their protein-protein interactions. Current Opinion in Chemical Biology, 13(3), 284-290.

Auld, D. S., Zhang, Y. -., Southall, N. T., Rai, G., Landsman, M., MacLure, J., et al. (2009). A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution. Journal of Medicinal Chemistry, 52(5), 1450-1458.

Bachovchin, D. A., Brown, S. J., Rosen, H., & Cravatt, B. F. (2009). Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes. Nature Biotechnology, 27(4), 387-394.

Barton, M., & Meyer, M. R. (2009). Postmenopausal hypertension: Mechanisms and therapy. Hypertension, 54(1), 11-18.

Baškovč, J., Bevk, D., Stanovnik, B., & Svete, J. (2009). Bis-enaminone based parallel solution-phase synthesis of 1,4-dihydropyridine derivatives. Journal of Combinatorial Chemistry, 11(3), 500-507.

Baxendale, I. R., Ley, S. V., Mansfield, A. C., & Smith, C. D. (2009). Multistep synthesis using modular flow reactors: Bestmann-ohira reagent for the formation of alkynes and triazoles. Angewandte Chemie - International Edition, 48(22), 4017-4021.

Bayne, C. J. (2009). Successful parasitism of vector snail biomphalaria glabrata by the human blood fluke (trematode) schistosoma mansoni: A 2009 assessment. Molecular and Biochemical Parasitology, 165(1), 8-18.

Bergsbaken, T., Fink, S. L., & Cookson, B. T. (2009). Pyroptosis: Host cell death and inflammation. Nature Reviews Microbiology, 7(2), 99-109.

Berrodin, T. J., Chang, K. C. N., Komm, B. S., Freedman, L. P., & Nagpal, S. (2009). Differential biochemical and cellular actions of premarin estrogens: Distinct pharmacology of bazedoxifene-conjugated estrogens combination. Molecular Endocrinology, 23(1), 74-85.

Bharate, S. B., Nemmani, K. V. S., & Vishwakarma, R. A. (2009). Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): An emerging target for type 2 diabetes. Expert Opinion on Therapeutic Patents, 19(2), 237-264.

Bickel, P. E., Tansey, J. T., & Welte, M. A. (2009). PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores. Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 1791(6), 419-440.

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Schneider, G., Hartenfeller, M., Reutlinger, M., Tanrikulu, Y., Proschak, E., & Schneider, P. (2009). Voyages to the (un)known: Adaptive design of bioactive compounds. Trends in Biotechnology, 27(1), 18-26.

Schulz, C., Von Andrian, U., & Massberg, S. (2009). Trafficking of murine hematopoietic stem and progenitor cells in health and vascular disease. Microcirculation, 16(6), 497-507.

Schwede, T., Sali, A., Honig, B., Levitt, M., Berman, H. M., Jones, D., et al. (2009). Outcome of a workshop on applications of protein models in biomedical research. Structure, 17(2), 151-159.

Schwerte, T. (2009). Cardio-respiratory control during early development in the model animal zebrafish. Acta Histochemica, 111(3), 230-243.

Scott, W. L., Alsina, J., Audu, C. O., Babaev, E., Cook, L., Dage, J. L., et al. (2009). Distributed drug discovery, part 2: Global rehearsal of alkylating agents for the synthesis of resin-bound unnatural amino acids and virtual D3 catalog construction. Journal of Combinatorial Chemistry, 11(1), 14-33.

Scott, W. L., & O'Donnell, M. J. (2009). Distributed drug discovery, part 1: Linking aeademia and combinatorial chemistry to find drug leads for developing world diseases. Journal of Combinatorial Chemistry, 11(1), 3-13.

Sergienko, E., Su, Y., Chan, X., Brown, B., Hurder, A., Narisawa, S., et al. (2009). Identification and characterization of novel tissue-nonspecific alkaline phosphatase inhibitors with diverse modes of action. Journal of Biomolecular Screening, 14(7), 824-837.

Servent, D., & Fruchart-Gaillard, C. (2009). Muscarinic toxins: Tools for the study of the pharmacological and functional properties of muscarinic receptors. Journal of Neurochemistry, 109(5), 1193-1202.

Severin, A., Joseph, R. E., Boyken, S., Fulton, D. B., & Andreotti, A. H. (2009). Proline isomerization preorganizes the itk SH2 domain for binding to the itk SH3 domain. Journal of Molecular Biology, 387(3), 726-743.

Shaw, A. S., & Filbert, E. L. (2009). Scaffold proteins and immune-cell signalling. Nature Reviews Immunology, 9(1), 47-56.

Shaw, J. T. (2009). Naturally diverse: Highlights in versatile synthetic methods enabling target- and diversity-oriented synthesis. Natural Product Reports, 26(1), 11-26.

Shimizu, T. (2009). Lipid mediators in health and disease: Enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation

Silverman, G. A., Luke, C. J., Bhatia, S. R., Long, O. S., Vetica, A. C., Perlmutter, D. H., et al. (2009). Modeling molecular and cellular aspects of human disease using the nematode caenorhabditis elegans. Pediatric Research, 65(1), 10-18.

Singh, N., Guha, R., Giulianotti, M. A., Pinilla, C., Houghten, R. A., & Medina-Franco, J. L. (2009). Chemoinformatic analysis of combinatorial libraries, drugs, natural products, and molecular libraries small molecule repository. Journal of Chemical Information and Modeling, 49(4), 1010-1024.

Sinha, R. K., Park, C., Hwang, I. -., Davis, M. D., & Kehrl, J. H. (2009). B lymphocytes exit lymph nodes through cortical lymphatic sinusoids by a mechanism independent of sphingosine-1-phosphate-mediated chemotaxis. Immunity, 30(3), 434-446.

Slack, M., Winkler, D., Krämer, J., & Hesterkamp, T. (2009). A multiplexed approach to hit finding. Current Opinion in Drug Discovery and Development, 12(3), 351-357.

Slysz, G. W., Baker, C. A. H., Bozsa, B. M., Dang, A., Percy, A. J., Bennett, M., et al. (2009). Hydra: Software for tailored processing of H/D exchange data from MS or tandem MS analyses. BMC Bioinformatics, 10

Smalter, A., Huan, J., & Lushington, G. (2009). Graph wavelet alignment kernels for drug virtual screening. Journal of Bioinformatics and Computational Biology, 7(3), 473-497.

Smiley, D. A., & Khalil, R. A. (2009). Estrogenic compounds, estrogen receptors and vascular cell signaling in the aging blood vessels. Current Medicinal Chemistry, 16(15), 1863-1887.

Smith, P. J., Khan, I. A., & Errington, R. J. (2009). Cytomics and cellular informatics - coping with asymmetry and heterogeneity in biological systems. Drug Discovery Today, 14(5-6), 271-277.

Smits, H. L. (2009). Prospects for the control of neglected tropical diseases by mass drug administration. Expert Review of Anti-Infective Therapy, 7(1), 37-56.

Sölder, E., Kremser, C., Rohr, I., Hutzler, P., & Debbage, P. (2009). Molecular mapping deep within a living human organ: Analysis of microvessel function on the timescale of seconds and with sub-micrometre spatial resolutio. Histochemistry and Cell Biology, 131(5), 537-551.

Solinas, R., DiCesare, J. C., & Baures, P. W. (2009). Parallel synthesis of a library of symmetrically- and dissymmetrically- disubstituted imidazole-4,5-dicarboxamides bearing amino acid esters. Molecules, 14(1), 352-363.

Soulère, L. (2009). Toward docking-based virtual screening for discovering antitubulin agents by targeting taxane and colchicine binding sites. ChemMedChem, 4(2), 161-163.

Spichty, M., Taly, A., Hagn, F., Kessler, H., Barluenga, S., Winssinger, N., et al. (2009). The HSP90 binding mode of a radicicol-like E-oxime determined by docking, binding free energy estimations, and NMR 15N chemical shifts. Biophysical Chemistry, 143(3), 111-123.

Stocks, M. J., Wilden, G. R. H., Pairaudeau, G., Perry, M. W. D., Steele, J., & Stonehouse, J. P. (2009). A practical method for targeted library design balancing lead-like properties with diversity. ChemMedChem, 4(5), 800-808.

Su, X. -., Ozawa, K., Yagi, H., Lim, S. P., Wen, D., Ekonomiuk, D., et al. (2009). NMR study of complexes between low molecular mass inhibitors and the west nile virus NS2B-NS3 protease. FEBS Journal, 276(15), 4244-4255.

Sukocheva, O., Wadham, C., & Xia, P. (2009). Role of sphingolipids in the cytoplasmic signaling of estrogens. Steroids, 74(7), 562-567.

Sukuru, S. C. K., Jenkins, J. L., Beckwith, R. E. J., Scheiber, J., Bender, A., Mikhailov, D., et al. (2009). Plate-based diversity selection based on empirical HTS data to enhance the number of hits and their chemical diversity. Journal of Biomolecular Screening, 14(6), 690-699.

Sweeney, J., Kouttab, N., & Kurtis, J. (2009). Stored red blood cell supernatant facilitates thrombin generation. Transfusion, 49(8), 1569-1579.

Takken, F. L. W., & Tameling, W. I. L. (2009). To nibble at plant resistance proteins. Science, 324(5928), 744-746.

Tan, H. Y., Ng, T. W., & Liew, O. W. (2009). Filterless fluorometry with enhanced sensitivity. Journal of Fluorescence, 19(2), 375-379.

Tao, R., Hoover, H. E., Zhang, J., Honbo, N., Alano, C. C., & Karliner, J. S. (2009). Cardiomyocyte S1P1 receptor-mediated extracellular signal-related kinase signaling and desensitization. Journal of Cardiovascular Pharmacology, 53(6), 486-494.

Terasawa, E., Noel, S. D., & Keen, K. L. (2009). Rapid action of oestrogen in luteinising hormone-releasing hormone neurones: The role of GPR30. Journal of Neuroendocrinology, 21(4), 316-321.

Thammacharoen, S., Geary, N., Lutz, T. A., Ogawa, S., & Asarian, L. (2009). Divergent effects of estradiol and the estrogen receptor-α agonist PPT on eating and activation of PVN CRH neurons in ovariectomized rats and mice. Brain Research, 1268(C), 88-96.

Thorpe, K. L., Maack, G., Benstead, R., & Tyler, C. R. (2009). Estrogenic wastewater treatment works effluents reduce egg production in fish. Environmental Science and Technology, 43(8), 2976-2982.

Tietze, L. F., & Krewer, B. (2009). Novel analogues of CC-1065 and the duocarmycins for the use in targeted tumour therapies. Anti-Cancer Agents in Medicinal Chemistry, 9(3), 304-325.

Titus, S. A., Beacham, D., Shahane, S. A., Southall, N., Xia, M., Huang, R., et al. (2009). A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel. Analytical Biochemistry, 394(1), 30-38.

Tomašić, T., & Mašič, L. P. (2009). Rhodanine as a privileged scaffold in drug discovery. Current Medicinal Chemistry, 16(13), 1596-1629.

Tomlinson, S. M., Malmstrom, R. D., & Watowich, S. J. (2009). New approaches to structure-based discovery of dengue protease inhibitors. Infectious Disorders - Drug Targets, 9(3), 327-343.

Top, S., Thibaudeau, C., Vessières, A., Brulé, E., Le Bideau, F., Joerger, J. -., et al. (2009). Synthesis and structure activity relationship of organometallic steroidal androgen derivatives. Organometallics, 28(5), 1414-1424.

Tu, G., Hu, D., Yang, G., & Yu, T. (2009). The correlation between GPR30 and clinicopathologic variables in breast carcinomas. Technology in Cancer Research and Treatment, 8(3), 231-234.

Turk, S., Kovač, A., Boniface, A., Bostock, J. M., Chopra, I., Blanot, D., et al. (2009). Discovery of new inhibitors of the bacterial peptidoglycan biosynthesis enzymes MurD and MurF by structure-based virtual screening. Bioorganic and Medicinal Chemistry, 17(5), 1884-1889.

Van Den Enden, E. (2009). Pharmacotherapy of helminth infection. Expert Opinion on Pharmacotherapy, 10(3), 435-451.

Villar, H. O., & Hansen, M. R. (2009). Mining and visualizing the chemical content of large databases. Current Opinion in Drug Discovery and Development, 12(3), 367-375.

Vincent, J. -., Artigas, A., Petersen, L. C., & Meyer, C. (2009). A multicenter, randomized, double-blind, placebo-controlled, dose-escalation trial assessing safety and efficacy of active site inactivated recombinant factor VIIa in subjects with acute lung injury or acute respiratory distress syndrome. Critical Care Medicine, 37(6), 1874-1880.

Vogel, P., Donoviel, M. S., Read, R., Hansen, G. M., Hazlewood, J., Anderson, S. J., et al. (2009). Incomplete inhibition of sphingosine 1-phosphate lyase modulates imune system function yet prevents early lethality and non-lymphoid lesions. PLoS ONE, 4(1)

Vogt, A., Cholewinski, A., Shen, X., Nelson, S. G., Lazo, J. S., Tsang, M., et al. (2009). Automated image-based phenotypic analysis in zebrafish embryos. Developmental Dynamics, 238(3), 656-663.

Wagner, R. N., Proell, M., Kufer, T. A., & Schwarzenbacher, R. (2009). Evaluation of nod-like receptor (NLR) effector domain interactions. PLoS ONE, 4(4)

Wallace, G. A., Gordon, T. D., Hayes, M. E., Konopacki, D. B., Fix-Stenzel, S. R., Zhang, X., et al. (2009). Scalable synthesis and isolation of the four stereoisomers of methyl 1-amino-3-(4-bromophenyl)cyclopentanecarboxylate, useful intermediates for the synthesis of S1P1 receptor agonists. Journal of Organic Chemistry, 74(13), 4886-4889.

Walser, M., Pellaux, R., Meyer, A., Bechtold, M., Vanderschuren, H., Reinhardt, R., et al. (2009). Novel method for high-throughput colony PCR screening in nanoliter-reactors. Nucleic Acids Research, 37(8)

Wang, X. -., Li, Q., Wu, J. -., & Tu, S. -. (2009). Efficient method for the synthesis of pyranoquinoline, thiopyranoquinoline, thienoquinoline, and naphtho[2,7]naphthyridine derivatives catalyzed by iodine. Journal of Combinatorial Chemistry, 11(3), 433-437.

Wang, Y., Xiao, J., Suzek, T. O., Zhang, J., Wang, J., & Bryant, S. H. (2009). PubChem: A public information system for analyzing bioactivities of small molecules. Nucleic Acids Research, 37(SUPPL. 2), W623-W633.

Weigert, A., Weis, N., & Brüne, B. (2009). Regulation of macrophage function by sphingosine-1-phosphate. Immunobiology, 214(9-10), 748-760.

Weiler, H., & Kerschen, E. (2009). Modulation of sepsis outcome with variants of activated protein C. Journal of Thrombosis and Haemostasis, 7(SUPPL. 1), 127-131.

Weill, N., & Rognan, D. (2009). Development and validation of a novel protein-ligand fingerprint to mine chemogenomic space: Application to G protein-coupled receptors and their ligands. Journal of Chemical Information and Modeling, 49(4), 1049-1062.

Wellendorph, P., Johansen, L. D., & Bräuner-Osborne, H. (2009). Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients. Molecular Pharmacology, 76(3), 453-465.

Wetzel, S., Klein, K., Renner, S., Rauh, D., Oprea, T. I., Mutzel, P., et al. (2009). Interactive exploration of chemical space with scaffold hunter. Nature Chemical Biology, 5(8), 581-583.

Wheeler, G. N., & Brändli, A. W. (2009). Simple vertebrate models for chemical genetics and drug discovery screens: Lessons from zebrafish and xenopus. Developmental Dynamics, 238(6), 1287-1308.

Williams, N. K., Bamert, R. S., Patel, O., Wang, C., Walden, P. M., Wilks, A. F., et al. (2009). Dissecting specificity in the janus kinases: The structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains. Journal of Molecular Biology, 387(1), 219-232.

Windahl, S. H., Andersson, N., Chagin, A. S., Mårtensson, U. E. A., Carlsten, H., Olde, B., et al. (2009). The role of the G protein-coupled receptor GPR30 in the effects of estrogen in ovariectomized mice. American Journal of Physiology - Endocrinology and Metabolism, 296(3), E490-E496.

Wu, Y. J., Chen, D. W., Liu, J. L., Zhang, J. H., Luo, H. S., & Cui, S. (2009). Estradiol promotes pituitary cell proliferation and gonadotroph differentiation at different doses and with different mechanisms in chick embryo. Steroids, 74(4-5), 441-448.

Xu, J., Ji, Y., Zhang, X., Drake, M., & Esmon, C. T. (2009). Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccaride-induced septic shock. Journal of Thrombosis and Haemostasis, 7(5), 851-856.

Xu, Y., Su, Y. -., & Yao, Y. -. (2009). Advances in research on pharmacokinetic models of high-throughput screening for drug discovery. Pharmaceutical Care and Research, 9(3), 218-221.

Xu, Y., & Li, X. -. (2009). Multi-target therapeutics and new drug discovery. Yaoxue Xuebao, 44(3), 226-230.

Yang, L., Ho, N. Y., Alshut, R., Legradi, J., Weiss, C., Reischl, M., et al. (2009). Zebrafish embryos as models for embryotoxic and teratological effects of chemicals. Reproductive Toxicology, 28(2), 245-253.

Yarmush, M. L., & King, K. R. (2009). Living-cell microarrays

Yaziji, V., Coelho, A., Maatougui, A. E., Brea, J., Loza, M. I., Garcia-Mera, X., et al. (2009). Divergent solution-phase synthesis of diarylpyrimidine libraries as selective A3 adenosine receptor antagonists. Journal of Combinatorial Chemistry, 11(4), 519-522.

Yet, L. (2009). Chapter 5.4: Five-membered ring systems: With more than one N atom

Yi, C. H., & Yuan, J. (2009). The jekyll and hyde functions of caspases. Developmental Cell, 16(1), 21-34.

Yonesu, K., Ohnuki, T., Ono, Y., Takatsu, T., & Nara, F. (2009). Ascotricins A and B, novel antagonists of sphingosine-1-phosphate receptor 1 from ascotricha chartarum berk. SANK 14186. Journal of Antibiotics, 62(7), 359-364.

Yonesu, K., Kawase, Y., Inoue, T., Takagi, N., Tsuchida, J., Takuwa, Y., et al. (2009). Involvement of sphingosine-1-phosphate and S1P1 in angiogenesis: Analyses using a new S1P1 antagonist of non-sphingosine-1-phosphate analog. Biochemical Pharmacology, 77(6), 1011-1020.

Yu, L., Mohanram, V., Simonson, O. E., Smith, C. I. E., Spetz, A. -., & Mohamed, A. J. (2009). Proteasome inhibitors block HIV-1 replication by affecting both cellular and viral targets. Biochemical and Biophysical Research Communications, 385(1), 100-105.

Yuan, M. -., Shuai, Q., Wang, L., Li, X. -., & Yu, R. -. (2009). 5-bromo-1-methyl-indolin-2-one. Acta Crystallographica Section E: Structure Reports Online, 65(7)

Zallocchi, M., Meehan, D. T., Delimont, D., Askew, C., Garige, S., Gratton, M. A., et al. (2009). Localization and expression of clarin-1, the Clrn1 gene product, in auditory hair cells and photoreceptors. Hearing Research, 255(1-2), 109-120.

Zambianchi, M., Di Maria, F., Cazzato, A., Gigli, G., Piacenza, M., Della Sala, F., et al. (2009). Microwave-assisted synthesis of thiophene fluorophores, labeling and multilabeling of monoclonal antibodies, and long lasting staining of fixed cells. Journal of the American Chemical Society, 131(31), 10892-10900.

Zaragoza-Sundqvist, M., Eriksson, H., Rohman, M., & Greasley, P. J. (2009). High-quality cost-effective compound management support for HTS. Journal of Biomolecular Screening, 14(5), 509-514.

Zhang, C. -., Xiao, S. -., Utzinger, J., Chollet, J., Keiser, J., & Tanner, M. (2009). Histopathological changes in adult schistosoma japonicum harbored in mice treated with a single dose of mefloquine. Parasitology Research, 104(6), 1407-1416.

Zhang, J., Sattler, M., Tonon, G., Grabher, C., Lababidi, S., Zimmerhackl, A., et al. (2009). Targeting angiogenesis via a c-Myc/hypoxia-inducible factor-1α- dependent pathway in multiple myeloma. Cancer Research, 69(12), 5082-5090.

Zhang, Y., Byun, Y., Ren, Y. R., Liu, J. O., Laterra, J., & Pomper, M. G. (2009). Identification of inhibitors of ABCG2 by a bioluminescence imaging-based high-throughput assay. Cancer Research, 69(14), 5867-5875.

Zhang, Z., Zhang, Z. -., Fauser, U., & Schluesener, H. J. (2009). Distribution of Foxp3+ T-regulatory cells in experimental autoimmune neuritis rats. Experimental Neurology, 216(1), 75-82.

Zhao, C. -., Deng, Q. -., Zhang, D. -., Cai, W. -., & Zhang, J. -. (2009). Developmental profile and subcellular localization of the non-genomic membranous estrogen receptor GPR30 in the hippocampus of postnatal female rats. Progress in Biochemistry and Biophysics, 36(1), 103-107.

Zhu, H., Ye, L., Richard, A., Golbraikh, A., Wright, F. A., Rusyn, I., et al. (2009). A novel two-step hierarchical quantitative structure-activity relationship modeling work flow for predicting acute toxicity of chemicals in rodents. Environmental Health Perspectives, 117(8), 1257-1264.

2007

Adelman, D. E., & Deangelis, K. L. (2007). Patent metrics: The mismeasure of innovation in the biotech patent debate. Texas Law Review, 85(7), 1677-1744.

Agrafiotis, D. K., Bandyopadhyay, D., Wegner, J. K., & Van Vlijmen, H. (2007). Recent advances in  chemoinformatics. Journal of Chemical Information and Modeling, 47(4), 1279-1293.

Baumruker, T., Billich, A., & Brinkmann, V. (2007). FTY720, an immunomodulatory sphingolipid mimetic: Translation of a novel mechanism into clinical benefit in multiple sclerosis. Expert Opinion on Investigational Drugs, 16(3), 283-289.

Biggins, J. B., & Koh, J. T. (2007). Chemical biology of steroid and nuclear hormone receptors. Current Opinion in Chemical Biology, 11(1), 99-110.

Bodnar, R. J. (2007). Endogenous opiates and behavior: 2006. Peptides, 28(12), 2435-2513.

Boonyaratanakornkit, V., & Edwards, D. P. (2007). Receptor mechanisms mediating non-genomic actions of sex steroids. Seminars in Reproductive Medicine, 25(3), 139-153.

Brinkmann, V. (2007). Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology. Pharmacology and Therapeutics, 115(1), 84-105.

Camp, D., Avery, V., Street, I., & Quinn, R. J. (2007). Progress toward establishing an open access molecular screening capability in the australasian region. ACS Chemical Biology, 2(12), 764-767.

Camp, D. (2007). Establishment of an open access compound management facility in australia to stimulate applied, basic and translational biomedical research. Drug Discovery World, 8(2), 61-64+66.

Carpenter, A. E. (2007). Image-based chemical screening. Nature Chemical Biology, 3(8), 461-465.

Chagin, A. S., & Sävendahl, L. (2007). Brief report: GPR30 estrogen receptor expression in the growth plate declines as puberty progresses. Journal of Clinical Endocrinology and Metabolism, 92(12), 4873-4877.

Chun, J. (2007). Immunology: The sources of a lipid conundrum. Science, 316(5822), 208-210.

Congdon, E. E., Necula, M., Blackstone, R. D., & Kuret, J. (2007). Potency of a tau fibrillization inhibitor is influenced by its aggregation state. Archives of Biochemistry and Biophysics, 465(1), 127-135.

Cooke, N., & Zécri, F. (2007). Chapter 16 sphingosine 1-phosphate type 1 receptor modulators: Recent advances and therapeutic potential

Craig Jordan, V., Lewis-Wambi, J., Kim, H., Cunliffe, H., Ariazi, E., Sharma, C. G. N., et al. (2007). Exploiting the apoptotic actions of oestrogen to reverse antihormonal drug resistance in oestrogen receptor positive breast cancer patients. Breast, 16(2 SUPPL.), 105-113.

Dams, G., Van Acker, K., Gustin, E., Vereycken, I., Bunkens, L., Holemans, P., et al. (2007). A time-resolved fluorescence assay to identify small-molecule inhibitors of HIV-1 fusion. Journal of Biomolecular Screening, 12(6), 865-874.

Di Virgilio, F. (2007). Liaisons dangereuses: P2X7 and the inflammasome. Trends in Pharmacological Sciences, 28(9), 465-472.

Dix, D. J., Houck, K. A., Martin, M. T., Richard, A. M., Setzer, R. W., & Kavlock, R. J. (2007). The toxcast program for prioritizing toxicity testing of environmental chemicals. Toxicological Sciences, 95(1), 5-12.

Dodge, J. A., & Richardson, T. I. (2007). Chapter 10 novel selective estrogen receptor modulators (SERMs)

Dolle, R. E., Le Bourdonnec, B., Goodman, A. J., Morales, G. A., Salvino, J. M., & Zhang, W. (2007). Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2006. Journal of Combinatorial Chemistry, 9(6), 855-902.

Dove, A. (2007). High-throughput screening goes to school. Nature Methods, 4(6), 523-532.

Duncan, J. A., & Pan-Yun Ting, J. (2007). Rebuilding host-pathogen interaction from the ground up: In vitro reconstitution of the inflammasome. Cell Host and Microbe, 1(1), 7-9.

Dyatlovitskaya, E. V. (2007). The role of lysosphingolipids in the regulation of biological processes. Biochemistry (Moscow), 72(5), 479-484.

Edwards, P. (2007). Manipulating molecular architecture in parallel. Drug Discovery Today, 12(3-4), 183-184.

Feldman, R. D., & Gros, R. (2007). Choreographing the rapid vascular effects of estrogen: Sorting out the partners and the steps. Hypertension, 49(6), 1222-1224.

Fenton, R. A., & Knepper, M. A. (2007). Urea and renal function in the 21st century: Insights from knockout mice. Journal of the American Society of Nephrology, 18(3), 679-688.

Fernandes-Alnemri, T., Wu, J., Yu, J. -., Datta, P., Miller, B., Jankowski, W., et al. (2007). The pyroptosome: A supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death and Differentiation, 14(9), 1590-1604.

Foss Jr., F. W., Snyder, A. H., Davis, M. D., Rouse, M., Okusa, M. D., Lynch, K. R., et al. (2007). Synthesis and biological evaluation of γ-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorganic and Medicinal Chemistry, 15(2), 663-677.

Freche, B., Reig, N., & Van Der Goot, F. G. (2007). The role of the inflammasome in cellular responses to toxins and bacterial effectors. Seminars in Immunopathology, 29(3), 249-260.

G. Shuker, D. E. (2007). Chemical genetics. Physical Chemistry Chemical Physics, 9(26), 165-173.

Gombos, K., Szele, E., Kiss, I., Varjas, T., Puskás, L., Kozma, L., et al. (2007). Characterization of microarray gene expression profiles of early stage thyroid tumours. Cancer Genomics and Proteomics, 4(6), 403-410.

Hahn, F., & Schepers, U. (2007). Solid phase chemistry for the directed synthesis of biologically active polyamine analogs, derivatives, and conjugates

Hammes, S. R., & Levin, E. R. (2007). Extranuclear steroid receptors: Nature and actions. Endocrine Reviews, 28(7), 726-741.

Hänel, P., Andréani, P., & Gräler, M. H. (2007). Erythrocytes store and release sphingosine 1-phosphate in blood. FASEB Journal, 21(4), 1202-1209.

Hanessian, S., Charron, G., Billich, A., & Guerini, D. (2007). Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors. Bioorganic and Medicinal Chemistry Letters, 17(2), 491-494.

Henry, T., & Monack, D. M. (2007). Activation of the inflammasome upon francisella tularensis infection: Interplay of innate immune pathways and virulence factors. Cellular Microbiology, 9(11), 2543-2551.

Huryn, D. M., & Cosford, N. D. P. (2007). Chapter 26 the molecular libraries screening center network (MLSCN): Identifying chemical probes of biological systems

Huwiler, A., & Zangemeister-Wittke, U. (2007). Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy. Critical Reviews in oncology/hematology, 63(2), 150-159.

Jin, Y., Birlea, S. A., Fain, P. R., & Spritz, R. A. (2007). Genetic variations in NALP1 are associated with generalized vitiligo in a romanian population. Journal of Investigative Dermatology, 127(11), 2558-2562.

Johnston, J. B., Rahman, M. M., & McFadden, G. (2007). Strategies that modulate inflammasomes - insights from host-pathogen interactions. Seminars in Immunopathology, 29(3), 261-274.

Johnston, P. A., Foster, C. A., Tong, Y. S., Skoko, J. J., Shinde, S., Wipf, P., et al. (2007). Development and implementation of a 384-well homogeneous fluorescence intensity high-throughput screening assay to identify mitogen-activated protein kinase phosphatase-1 dual-specificity protein phosphatase inhibitors. Assay and Drug Development Technologies, 5(3), 319-332.

Jones, J., Rodgers, J., Heil, M., May, J., White, L., Maddry, J. A., et al. (2007). High throughput drug screening for human immunodeficiency virus type 1 reactivating compounds. Assay and Drug Development Technologies, 5(2), 181-189.

Jordan, V. C., & O'Malley, B. W. (2007). Selective estrogen-receptor modulators and antihormonal resistance in breast cancer. Journal of Clinical Oncology, 25(36), 5815-5824.

Jung, C. G., Kim, H. J., Miron, V. E., Cook, S., Kennedy, T. E., Foster, C. A., et al. (2007). Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells. Glia, 55(16), 1656-1667.

Kanneganti, T. -., Lamkanfi, M., & Núñez, G. (2007). Intracellular NOD-like receptors in host defense and disease. Immunity, 27(4), 549-559.

Kawasumi, M., & Nghiem, P. (2007). Chemical genetics: Elucidating biological systems with small-molecule compounds. Journal of Investigative Dermatology, 127(7), 1577-1584.

Kenakin, T., & Domanico, P. (2007). Pharmacologists get a bigger and better tool box. Current Opinion in Pharmacology, 7(5), 505-506.

Kofoed, J., & Reymond, J. -. (2007). Identification of protease substrates by combinatorial profiling on TentaGel beads. Chemical Communications, (43), 4453-4455.

Kozarich, J. W. (2007). New LSD therapies unfolding. Chemistry and Biology, 14(9), 976-977.

Lazo, J. S., Brady, L. S., & Dingledine, R. (2007). Building a pharmacological lexicon: Small molecule discovery in academia. Molecular Pharmacology, 72(1), 1-7.

Martinon, F., Gaide, O., Pétrilli, V., Mayor, A., & Tschopp, J. (2007). NALP inflammasomes: A central role in innate immunity. Seminars in Immunopathology, 29(3), 213-229.

McDermott, M. F., & Tschopp, J. (2007). From inflammasomes to fevers, crystals and hypertension: How basic research explains inflammatory diseases. Trends in Molecular Medicine, 13(9), 381-388.

Meyer zu Heringdorf, D., & Jakobs, K. H. (2007). Lysophospholipid receptors: Signalling, pharmacology and regulation by lysophospholipid metabolism. Biochimica Et Biophysica Acta - Biomembranes, 1768(4), 923-940.

Miao, E. A., Andersen-Nissen, E., Warren, S. E., & Aderem, A. (2007). TLR5 and ipaf: Dual sensors of bacterial flagellin in the innate immune system. Seminars in Immunopathology, 29(3), 275-288.

Mitchell, M. O. (2007). Antibacterial agents against methicillin-resistant staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Anti-Infective Agents in Medicinal Chemistry, 6(4), 243-247.

Mitra, P., Payne, S. G., Milstien, S., & Spiegel, S. (2007). A rapid and sensitive method to measure secretion of sphingosine-1-phosphate

Muller, C. D., Peluso, J., Tabaka-Moreira, H., Taquet, N., Dumont, S., & Reimund, J. -. (2007). Can flow cytometry play a part in cell based high-content screening? Cytometry Part A, 71(11), 901-904.

Murph, M., & Mills, G. B. (2007). Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression. Expert Reviews in Molecular Medicine, 9(28), 1-18.

Murphy, E., & Steenbergen, C. (2007). Gender-based differences in mechanisms of protection in myocardial ischemia-reperfusion injury. Cardiovascular Research, 75(3), 478-486.

Myat, L. O., Thangada, S., Wu, M. -., Liu, C. H., Macdonald, T. L., Lynch, K. R., et al. (2007). Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. Journal of Biological Chemistry, 282(12), 9082-9089.

Nakamura, T., Yonesu, K., Mizuno, Y., Suzuki, C., Sakata, Y., Takuwa, Y., et al. (2007). Synthesis and SAR studies of a novel class of S1P1 receptor antagonists. Bioorganic and Medicinal Chemistry, 15(10), 3548-3564.

Narita, S. -., Goldblum, R. M., Watson, C. S., Brooks, E. G., Estes, D. M., Curran, E. M., et al. (2007). Environmental estrogens induce mast cell degranulation and enhance IgE-mediated release of allergic mediators. Environmental Health Perspectives, 115(1), 48-52.

Neilson, J. R., Zheng, G. X. Y., Burge, C. B., & Sharp, P. A. (2007). Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes and Development, 21(5), 578-589.

Nombela-Arrieta, C., Mempel, T. R., Soriano, S. F., Mazo, I., Wymann, M. P., Hirsch, E., et al. (2007). A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. Journal of Experimental Medicine, 204(3), 497-510.

Okamoto, I., Yamasaki, R., Sawamura, M., Kato, T., Nagayama, N., Takeya, T., et al. (2007). Redox-induced conformational alteration of N,N-diarylamides. Organic Letters, 9(26), 5545-5547.

Omori, K., Shikata, Y., Sarai, K., Watanabe, N., Wada, J., Goda, N., et al. (2007). Edaravone mimics sphingosine-1-phosphate-induced endothelial barrier enhancement in human microvascular endothelial cells. American Journal of Physiology - Cell Physiology, 293(5), C1523-C1531.

Onuoha, S. C., Mukund, S. R., Coulstock, E. T., Sengerovà, B., Shaw, J., McLaughlin, S. H., et al. (2007). Mechanistic studies on Hsp90 inhibition by ansamycin derivatives. Journal of Molecular Biology, 372(2), 287-297.

Oprea, T. I., Tropsha, A., Faulon, J. -., & Rintoul, M. D. (2007). Systems chemical biology. Nature Chemical Biology, 3(8), 447-450.

Oprea, T. I., Allu, T. K., Fara, D. C., Rad, R. F., Ostopovici, L., & Bologa, C. G. (2007). Lead-like, drug-like or "pub-like": How different are they? Journal of Computer-Aided Molecular Design, 21(1-3), 113-119.

Osak, B., & Fitzgerald, L. R. (2007). A β-lactamase reporter assay for monitoring the activation of the smoothened pathway. Assay and Drug Development Technologies, 5(6), 785-792.

Osinde, M., Mullershausen, F., & Dev, K. K. (2007). Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors. Neuropharmacology, 52(5), 1210-1218.

Oskeritzian, C. A., Milstien, S., & Spiegel, S. (2007). Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis. Pharmacology and Therapeutics, 115(3), 390-399.

Pabst, R. (2007). Plasticity and heterogeneity of lymphoid organs. what are the criteria to call a lymphoid organ primary, secondary or tertiary? Immunology Letters, 112(1), 1-8.

Pedra, J. H. F., Sutterwala, F. S., Sukumaran, B., Ogura, Y., Qian, F., Montgomery, R. R., et al. (2007). ASC/PYCARD and caspase-1 regulate the IL-18/IFN-γ axis during anaplasma phagocytophilum infection. Journal of Immunology, 179(7), 4783-4791.

Peters, S. L., & Alewijnse, A. E. (2007). Sphingosine-1-phosphate signaling in the cardiovascular system. Current Opinion in Pharmacology, 7(2), 186-192.

Petrie, H. T., & Zúñiga-Pflücker, J. C. (2007). Zoned out: Functional mapping of stromal signaling microenvironments in the thymus

Pétrilli, V., Dostert, C., Muruve, D. A., & Tschopp, J. (2007). The inflammasome: A danger sensing complex triggering innate immunity. Current Opinion in Immunology, 19(6), 615-622.

Pétrilli, V., Papin, S., Dostert, C., Mayor, A., Martinon, F., & Tschopp, J. (2007). Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death and Differentiation, 14(9), 1583-1589.

Pietras, R. J., & Márquez-Garbán, D. C. (2007). Membrane-associated estrogen receptor signaling pathways in human cancers. Clinical Cancer Research, 13(16), 4672-4676.

Pohjala, L., Hakkola, J., & Vuorela, P. (2007). Predictive value of cellular methods in toxicological evaluation of lead candidates: An insight to hepatotoxicity. Drug Discovery Today: Technologies, 4(3-4), e97-e101.

Reddy, A. S., Pati, S. P., Kumar, P. P., Pradeep, H. N., & Sastry, G. N. (2007). Virtual screening in drug discovery - A computational perspective. Current Protein and Peptide Science, 8(4), 329-351.

Regitz-Zagrosek, V., Wintermantel, T. M., & Schubert, C. (2007). Estrogens and SERMs in coronary heart disease. Current Opinion in Pharmacology, 7(2), 130-139.

Rodrigues, D. J., Lyons, R., Laflin, P., Pointon, W., & Kammonen, J. (2007). A three-stage experimental strategy to evaluate and validate an interplate IC50 format. Assay and Drug Development Technologies, 5(6), 805-813.

Sakurai, A., Kurata, A., Onishi, Y., Hirano, H., & Ishikawa, T. (2007). Prediction of drug-induced intrahepatic cholestasis: In vitro screening and QSAR analysis of drugs inhibiting the human bile salt export pump. Expert Opinion on Drug Safety, 6(1), 71-86.

Sankala, H. M., Hait, N. C., Paugh, S. W., Shida, D., Lépine, S., Elmore, L. W., et al. (2007). Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. Cancer Research, 67(21), 10466-10474.

Schuffenhauer, A., Ertl, P., Roggo, S., Wetzel, S., Koch, M. A., & Waldmann, H. (2007). The scaffold tree - visualization of the scaffold universe by hierarchical scaffold classification. Journal of Chemical Information and Modeling, 47(1), 47-58.

Schwab, S. R., & Cyster, J. G. (2007). Finding a way out: Lymphocyte egress from lymphoid organs. Nature Immunology, 8(12), 1295-1301.

Scior, T., Bernard, P., Medina-Franco, J. L., & Maggiora, G. M. (2007). Large compound databases for structure-activity relationships studies in drug discovery. Mini-Reviews in Medicinal Chemistry, 7(8), 851-860.

Scott, P. -., Tremblay, A., Brochu, M., & St-Louis, J. (2007). Vasorelaxant action of 17β-estradiol in rat uterine arteries: Role of nitric oxide synthases and estrogen receptors. American Journal of Physiology - Heart and Circulatory Physiology, 293(6), H3713-H3719.

Seshadri, S., Duncan, M. D., Hart, J. M., Gavrilin, M. A., & Wewers, M. D. (2007). Pyrin levels in human monocytes and monocyte-derived macrophages regulate IL-1β processing and release. Journal of Immunology, 179(2), 1274-1281.

Shah, J. Z., & Bt Salim, N. (2007). A soft hierarchical algorithm for the clustering of multiple bioactive chemical compounds. Paper presented at the , 4414 LNBI 140-153.

Sidransky, E., LaMarca, M. E., & Ginns, E. I. (2007). Therapy for gaucher disease: Don't stop thinking about tomorrow. Molecular Genetics and Metabolism, 90(2), 122-125.

Skoura, A., Sanchez, T., Claffey, K., Mandala, S. M., Proia, R. L., & Hla, T. (2007). Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. Journal of Clinical Investigation, 117(9), 2506-2516.

Southan, C., Várkonyi, P., & Muresan, S. (2007). Complementarity between public and commercial databases: New opportunities in medicinal chemistry informatics. Current Topics in Medicinal Chemistry, 7(15), 1502-1508.

Spiegel, S., & Milstien, S. (2007). Functions of the multifaceted family of sphingosine kinases and some close relatives. Journal of Biological Chemistry, 282(4), 2125-2129.

Spritz, R. A. (2007). The genetics of generalized vitiligo and associated autoimmune diseases. Pigment Cell Research, 20(4), 271-278.

Stehlik, C., & Dorfleutner, A. (2007). COPs and POPs: Modulators of inflammasome activity. Journal of Immunology, 179(12), 7993-7998.

Stein, V., Sielaff, I., Johnsson, K., & Hollfelder, F. (2007). A covalent chemical genotype-phenotype linkage for in vitro protein evolution. ChemBioChem, 8(18), 2191-2194.

Taussig, M. J., Stoevesandt, O., Borrebaeck, C. A. K., Bradbury, A. R., Cahill, D., Cambillau, C., et al. (2007). ProteomeBinders: Planning a european resource of affinity reagents for analysis of the human proteome. Nature Methods, 4(1), 13-17.

Tierno, M. B., Johnston, P. A., Foster, C., Skoko, J. J., Shinde, S. N., Shun, T. Y., et al. (2007). Development and optimization of high-throughput in vitro protein phosphatase screening assays. Nature Protocols, 2(5), 1134-1144.

Tikhonova, I. G., Chi, S. S., Neumann, S., Thomas, C. J., Raaka, B. M., Costanzi, S., et al. (2007). Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition. Journal of Medicinal Chemistry, 50(13), 2981-2989.

Vasudevan, N., & Pfaff, D. W. (2007). Membrane-initiated actions of estrogens in neuroendocrinology: Emerging principles. Endocrine Reviews, 28(1), 1-19.

Wallqvist, A., Huang, R., & Covell, D. G. (2007). Chemoinformatic analysis of NCI preclinical tumor data: Evaluating compound efficacy from mouse xenograft data, NCI-60 screening data, and compound descriptors. Journal of Chemical Information and Modeling, 47(4), 1414-1427.

Walzer, T., Chiossone, L., Chaix, J., Calver, A., Carozzo, C., Garrigue-Antar, L., et al. (2007). Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor. Nature Immunology, 8(12), 1337-1344.

Weiss, D. S., Henry, T., & Monack, D. M. (2007). Francisella tularensis: Activation of the inflammasome

Wells, J. A., & McClendon, C. L. (2007). Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature, 450(7172), 1001-1009.

Wetzel, S., Schuffenhauer, A., Roggo, S., Ertl, P., & Waldmann, H. (2007). Cheminformatic analysis of natural products and their chemical space. Chimia, 61(6), 355-360.

Winzell, M. S., & Ahrén, B. (2007). G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes. Pharmacology and Therapeutics, 116(3), 437-448.

Wu, G. S. (2007). Role of mitogen-activated protein kinase phosphatases (MKPs) in cancer. Cancer and Metastasis Reviews, 26(3-4), 579-585.

Yu, J. -., Fernandes-Alnemri, T., Datta, P., Wu, J., Juliana, C., Solorzano, L., et al. (2007). Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants. Molecular Cell, 28(2), 214-227.

Zhang, Z., & Schluesener, H. J. (2007). FTY720: A most promising immunosuppressant modulating immune cell functions. Mini-Reviews in Medicinal Chemistry, 7(8), 845-850.

Zhang, Z., Wang, P., Ding, N., Song, G., & Li, Y. (2007). Total synthesis of cleistetroside-2, partially acetylated dodecanyl tetrarhamnoside derivative isolated from cleistopholis patens and cleistopholis glauca. Carbohydrate Research, 342(9), 1159-1168.

Zhao, Y., He, D., Zhao, J., Wang, L., Leff, A. R., Spannhake, E. W., et al. (2007). Lysophosphatidic acid induces interleukin-13 (IL-13) receptor α2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells. Journal of Biological Chemistry, 282(14), 10172-10179.

Zhao, Z., Xiao, Y., Elson, P., Tan, H., Plummer, S. J., Berk, M., et al. (2007). Plasma lysophosphatidylcholine levels: Potential biomarkers for colorectal cancer. Journal of Clinical Oncology, 25(19), 2696-2701.

2006

Beller, M., & Oliver, B. (2006). One hundred years of high-throughput drosophila research. Chromosome Research, 14(4), 349-362. Retrieved from www.scopus.com

Choi, Y., Shimogawa, H., Murakami, K., Ramdas, L., Zhang, W., Qin, J., et al. (2006). Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2. Chemistry and Biology, 13(3), 241-249. Retrieved from www.scopus.com

Collins, I., & Workman, P. (2006). New approaches to molecular cancer therapeutics. Nature Chemical Biology, 2(12), 689-700. Retrieved from www.scopus.com

Cornil, C. A., Ball, G. F., & Balthazart, J. (2006). Functional significance of the rapid regulation of brain estrogen action: Where do the estrogens come from? Brain Research, 1126(1), 2-26. Retrieved from www.scopus.com

De Haro, L., & Panda, S. (2006). Systems biology of circadian rhythms: An outlook. Journal of Biological Rhythms, 21(6), 507-518. Retrieved from www.scopus.com

Goodnow Jr., R. A. (2006). Hit and lead identification: Integrated technology-based approaches. Drug Discovery Today: Technologies, 3(4), 367-375. Retrieved from www.scopus.com

Hirano, H., Kurata, A., Onishi, Y., Sakurai, A., Saito, H., Nakagawa, H., et al. (2006). High-speed screening and QSAR analysis of human ATP-binding cassette transporter ABCB11 (bile salt export pump) to predict drug-induced intrahepatic cholestasis. Molecular Pharmaceutics, 3(3), 252-265. Retrieved from www.scopus.com

Insel, T. R. (2006). Translational research in the decade of discovery. Hormones and Behavior, 50(4), 504-505. Retrieved from www.scopus.com

Irwin, J. J. (2006). How good is your screening library? Current Opinion in Chemical Biology, 10(4), 352-356. Retrieved from www.scopus.com

Kozikowski, A. P., Roth, B., & Tropsha, A. (2006). Why academic drug discovery makes sense [2]. Science, 313(5791), 1235-1236. Retrieved from www.scopus.com

Krier, M., Bret, G., & Rognan, D. (2006). Assessing the scaffold diversity of screening libraries. Journal of Chemical Information and Modeling, 46(2), 512-524. Retrieved from www.scopus.com

Lazo, J. S. (2006). Roadmap or roadkill: A pharmacologist's analysis of the NIH molecular libraries initiative. Molecular Interventions, 6(5), 240-243. Retrieved from www.scopus.com

Li, A., Mustafi, D., Fu, Q., Tereshko, V., Chen, D. L., Tice, J. D., et al. (2006). Nanoliter microfluidic hybrid method for simultaneous screening and optimization validated with crystallization of membrane proteins. Proceedings of the National Academy of Sciences of the United States of America, 103(51), 19243-19248. Retrieved from www.scopus.com

Lipinski, C. A. (2006). The anti-intellectual effects of intellectual property. Current Opinion in Chemical Biology, 10(4), 380-383. Retrieved from www.scopus.com

Muegge, I., & Oloff, S. (2006). Advances in virtual screening. Drug Discovery Today: Technologies, 3(4), 405-411. Retrieved from www.scopus.com

Ogretmen, B. (2006). Sphingolipids in cancer: Regulation of pathogenesis and therapy. FEBS Letters, 580(23), 5467-5476. Retrieved from www.scopus.com

Oprea, T. I., & Tropsha, A. (2006). Target, chemical and bioactivity databases - integration is key. Drug Discovery Today: Technologies, 3(4), 357-365. Retrieved from www.scopus.com

Paolini, G. V., Shapland, R. H. B., Van Hoorn, W. P., Mason, J. S., & Hopkins, A. L. (2006). Global mapping of pharmacological space. Nature Biotechnology, 24(7), 805-815. Retrieved from www.scopus.com

Parker, C. N., & Bajorath, J. (2006). Towards unified compound screening strategies: A critical evaluation of error sources in experimental and virtual high-throughput screening. QSAR and Combinatorial Science, 25(12), 1153-1161. Retrieved from www.scopus.com

Prakesch, M., Sharma, U., Sharma, M., Khadem, S., Leek, D. M., & Arya, P. (2006). Part 1. modular approach to obtaining diverse tetrahydroquinoline-derived polycyclic skeletons for use in high-throughput generation of natural-product-like chemical probes. Journal of Combinatorial Chemistry, 8(5), 715-734. Retrieved from www.scopus.com

Richard, A. M. (2006). Future of toxicology-predictive toxicology: An expanded view of "chemical toxicity". Chemical Research in Toxicology, 19(10), 1257-1262. Retrieved from www.scopus.com

Richard, A. M., Gold, L. S., & Nicklaus, M. C. (2006). Chemical structure indexing of toxicity data on the internet: Moving toward a flat world. Current Opinion in Drug Discovery and Development, 9(3), 314-325. Retrieved from www.scopus.com

Schuffenhauer, A., & Brown, N. (2006). Chemical diversity and biological activity. Drug Discovery Today: Technologies, 3(4), 387-395. Retrieved from www.scopus.com

Schultz, C. (2006). Lipid-induced phenotypes. Nature Chemical Biology, 2(8), 396-398. Retrieved from www.scopus.com

Seuwen, K., Ludwig, M. -., & Wolf, R. M. (2006). Receptors for protons or lipid messengers or both? Journal of Receptors and Signal Transduction, 26(5-6), 599-610. Retrieved from www.scopus.com

Sharma, U., Srivastava, S., Prakesch, M., Sharma, M., Leek, D. M., & Arya, P. (2006). Part 2: Building diverse natural-product-like architectures from a tetrahydroaminoquinoline scaffold. modular solution- and solid-phase approaches for use in high-throughput generation of chemical probes. Journal of Combinatorial Chemistry, 8(5), 735-761. Retrieved from www.scopus.com

Shoichet, B. K. (2006). Interpreting steep dose-response curves in early inhibitor discovery. Journal of Medicinal Chemistry, 49(25), 7274-7277. Retrieved from www.scopus.com

Stahl, D., & Sibrowski, W. (2006). Editorial: Hot topic: Autoimmunity. Current Pharmaceutical Design, 12(2), 129-130. Retrieved from www.scopus.com

Uga, H., Kuramori, C., Ohta, A., Tsuboi, Y., Tanaka, H., Hatakeyama, M., et al. (2006). A new mechanism of methotrexate action revealed by target screening with affinity beads. Molecular Pharmacology, 70(5), 1832-1839. Retrieved from www.scopus.com

Weatherman, R. V. (2006). Untangling the estrogen receptor web. Nature Chemical Biology, 2(4), 175-176. Retrieved from www.scopus.com

Wehling, M., & Lösel, R. (2006). Non-genomic steroid hormone effects: Membrane or intracellular receptors? Journal of Steroid Biochemistry and Molecular Biology, 102(1-5 SPEC. ISS.), 180-183. Retrieved from www.scopus.com

Wild, D. J., & Wiggins, G. D. (2006). Challenges for chemoinformatics education in drug discovery. Drug Discovery Today, 11(9-10), 436-439. Retrieved from www.scopus.com

Willighagen, E. L., Wehrens, R., & Buydens, L. M. C. (2006). Molecular chemometrics. Critical Reviews in Analytical Chemistry, 36(3-4), 189-198. Retrieved from www.scopus.com

2004-2005

Bologa, C., Allu, T. K., Olah, M., Kappler, M. A., & Oprea, T. I. (2005). Descriptor collision and confusion: Toward the design of descriptors to mask chemical structures. Journal of Computer-Aided Molecular Design, 19(9-10), 625-635. Retrieved from www.scopus.com

Eguchi, Y. (2005). Chemogenomics. Folia Pharmacologica Japonica, 125(6), 365-371. Retrieved from www.scopus.com

Girke, T., Cheng, L. -., & Raikhel, N. (2005). ChemMine. A compound mining database for chemical genomics. Plant Physiology, 138(2), 573-577. Retrieved from www.scopus.com

Haggarty, S. J. (2005). The principle of complementarity: Chemical versus biological space. Current Opinion in Chemical Biology, 9(3), 296-303. Retrieved from www.scopus.com

Hodder, P. (2005). Building a uHTS laboratory. communications from the frontier. Drug Discovery World, 7(1), 31-42. Retrieved from www.scopus.com

Hopkins, A., Lanfear, J., Lipinski, C., & Beeley, L. (2005). Chemical tools for indications discovery Retrieved from www.scopus.com

Kaiser, D., Zdrazil, B., & Ecker, G. F. (2005). Similarity-based descriptors (SIBAR) - A tool for safe exchange of chemical information? Journal of Computer-Aided Molecular Design, 19(9-10), 687-692. Retrieved from www.scopus.com

Lengauer, C., Diaz Jr., L. A., & Saha, S. (2005). Cancer drug discovery through collaboration. Nature Reviews Drug Discovery, 4(5), 375-380. Retrieved from www.scopus.com

O'Connor, K. A., & Roth, B. L. (2005). Finding new tricks for old drugs: An efficient route for public-sector drug discovery. Nature Reviews Drug Discovery, 4(12), 1005-1014. Retrieved from www.scopus.com

Shang, S., & Tan, D. S. (2005). Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries. Current Opinion in Chemical Biology, 9(3), 248-258. Retrieved from www.scopus.com

Webb, T. R. (2005). Current directions in the evolution of compound libraries. Current Opinion in Drug Discovery and Development, 8(3), 303-308. Retrieved from www.scopus.com

Workman, P. (2005). Genomics and the second golden era of cancer drug development. Molecular BioSystems, 1(1), 17-26. Retrieved from www.scopus.com