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(114) Indirect Publications in 2007

Adelman, D. E., & Deangelis, K. L. (2007). Patent metrics: The mismeasure of innovation in the biotech patent debate. Texas Law Review, 85(7), 1677-1744.

Agrafiotis, D. K., Bandyopadhyay, D., Wegner, J. K., & Van Vlijmen, H. (2007). Recent advances in  chemoinformatics. Journal of Chemical Information and Modeling, 47(4), 1279-1293.

Baumruker, T., Billich, A., & Brinkmann, V. (2007). FTY720, an immunomodulatory sphingolipid mimetic: Translation of a novel mechanism into clinical benefit in multiple sclerosis. Expert Opinion on Investigational Drugs, 16(3), 283-289.

Biggins, J. B., & Koh, J. T. (2007). Chemical biology of steroid and nuclear hormone receptors. Current Opinion in Chemical Biology, 11(1), 99-110.

Bodnar, R. J. (2007). Endogenous opiates and behavior: 2006. Peptides, 28(12), 2435-2513.

Boonyaratanakornkit, V., & Edwards, D. P. (2007). Receptor mechanisms mediating non-genomic actions of sex steroids. Seminars in Reproductive Medicine, 25(3), 139-153.

Brinkmann, V. (2007). Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology. Pharmacology and Therapeutics, 115(1), 84-105.

Camp, D., Avery, V., Street, I., & Quinn, R. J. (2007). Progress toward establishing an open access molecular screening capability in the australasian region. ACS Chemical Biology, 2(12), 764-767.

Camp, D. (2007). Establishment of an open access compound management facility in australia to stimulate applied, basic and translational biomedical research. Drug Discovery World, 8(2), 61-64+66.

Carpenter, A. E. (2007). Image-based chemical screening. Nature Chemical Biology, 3(8), 461-465.

Chagin, A. S., & Sävendahl, L. (2007). Brief report: GPR30 estrogen receptor expression in the growth plate declines as puberty progresses. Journal of Clinical Endocrinology and Metabolism, 92(12), 4873-4877.

Chun, J. (2007). Immunology: The sources of a lipid conundrum. Science, 316(5822), 208-210.

Congdon, E. E., Necula, M., Blackstone, R. D., & Kuret, J. (2007). Potency of a tau fibrillization inhibitor is influenced by its aggregation state. Archives of Biochemistry and Biophysics, 465(1), 127-135.

Cooke, N., & Zécri, F. (2007). Chapter 16 sphingosine 1-phosphate type 1 receptor modulators: Recent advances and therapeutic potential

Craig Jordan, V., Lewis-Wambi, J., Kim, H., Cunliffe, H., Ariazi, E., Sharma, C. G. N., et al. (2007). Exploiting the apoptotic actions of oestrogen to reverse antihormonal drug resistance in oestrogen receptor positive breast cancer patients. Breast, 16(2 SUPPL.), 105-113.

Dams, G., Van Acker, K., Gustin, E., Vereycken, I., Bunkens, L., Holemans, P., et al. (2007). A time-resolved fluorescence assay to identify small-molecule inhibitors of HIV-1 fusion. Journal of Biomolecular Screening, 12(6), 865-874.

Di Virgilio, F. (2007). Liaisons dangereuses: P2X7 and the inflammasome. Trends in Pharmacological Sciences, 28(9), 465-472.

Dix, D. J., Houck, K. A., Martin, M. T., Richard, A. M., Setzer, R. W., & Kavlock, R. J. (2007). The toxcast program for prioritizing toxicity testing of environmental chemicals. Toxicological Sciences, 95(1), 5-12.

Dodge, J. A., & Richardson, T. I. (2007). Chapter 10 novel selective estrogen receptor modulators (SERMs)

Dolle, R. E., Le Bourdonnec, B., Goodman, A. J., Morales, G. A., Salvino, J. M., & Zhang, W. (2007). Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2006. Journal of Combinatorial Chemistry, 9(6), 855-902.

Dove, A. (2007). High-throughput screening goes to school. Nature Methods, 4(6), 523-532.

Duncan, J. A., & Pan-Yun Ting, J. (2007). Rebuilding host-pathogen interaction from the ground up: In vitro reconstitution of the inflammasome. Cell Host and Microbe, 1(1), 7-9.

Dyatlovitskaya, E. V. (2007). The role of lysosphingolipids in the regulation of biological processes. Biochemistry (Moscow), 72(5), 479-484.

Edwards, P. (2007). Manipulating molecular architecture in parallel. Drug Discovery Today, 12(3-4), 183-184.

Feldman, R. D., & Gros, R. (2007). Choreographing the rapid vascular effects of estrogen: Sorting out the partners and the steps. Hypertension, 49(6), 1222-1224.

Fenton, R. A., & Knepper, M. A. (2007). Urea and renal function in the 21st century: Insights from knockout mice. Journal of the American Society of Nephrology, 18(3), 679-688.

Fernandes-Alnemri, T., Wu, J., Yu, J. -., Datta, P., Miller, B., Jankowski, W., et al. (2007). The pyroptosome: A supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death and Differentiation, 14(9), 1590-1604.

Foss Jr., F. W., Snyder, A. H., Davis, M. D., Rouse, M., Okusa, M. D., Lynch, K. R., et al. (2007). Synthesis and biological evaluation of γ-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorganic and Medicinal Chemistry, 15(2), 663-677.

Freche, B., Reig, N., & Van Der Goot, F. G. (2007). The role of the inflammasome in cellular responses to toxins and bacterial effectors. Seminars in Immunopathology, 29(3), 249-260.

G. Shuker, D. E. (2007). Chemical genetics. Physical Chemistry Chemical Physics, 9(26), 165-173.

Gombos, K., Szele, E., Kiss, I., Varjas, T., Puskás, L., Kozma, L., et al. (2007). Characterization of microarray gene expression profiles of early stage thyroid tumours. Cancer Genomics and Proteomics, 4(6), 403-410.

Hahn, F., & Schepers, U. (2007). Solid phase chemistry for the directed synthesis of biologically active polyamine analogs, derivatives, and conjugates

Hammes, S. R., & Levin, E. R. (2007). Extranuclear steroid receptors: Nature and actions. Endocrine Reviews, 28(7), 726-741.

Hänel, P., Andréani, P., & Gräler, M. H. (2007). Erythrocytes store and release sphingosine 1-phosphate in blood. FASEB Journal, 21(4), 1202-1209.

Hanessian, S., Charron, G., Billich, A., & Guerini, D. (2007). Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors. Bioorganic and Medicinal Chemistry Letters, 17(2), 491-494.

Henry, T., & Monack, D. M. (2007). Activation of the inflammasome upon francisella tularensis infection: Interplay of innate immune pathways and virulence factors. Cellular Microbiology, 9(11), 2543-2551.

Huryn, D. M., & Cosford, N. D. P. (2007). Chapter 26 the molecular libraries screening center network (MLSCN): Identifying chemical probes of biological systems

Huwiler, A., & Zangemeister-Wittke, U. (2007). Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy. Critical Reviews in oncology/hematology, 63(2), 150-159.

Jin, Y., Birlea, S. A., Fain, P. R., & Spritz, R. A. (2007). Genetic variations in NALP1 are associated with generalized vitiligo in a romanian population. Journal of Investigative Dermatology, 127(11), 2558-2562.

Johnston, J. B., Rahman, M. M., & McFadden, G. (2007). Strategies that modulate inflammasomes – insights from host-pathogen interactions. Seminars in Immunopathology, 29(3), 261-274.

Johnston, P. A., Foster, C. A., Tong, Y. S., Skoko, J. J., Shinde, S., Wipf, P., et al. (2007). Development and implementation of a 384-well homogeneous fluorescence intensity high-throughput screening assay to identify mitogen-activated protein kinase phosphatase-1 dual-specificity protein phosphatase inhibitors. Assay and Drug Development Technologies, 5(3), 319-332.

Jones, J., Rodgers, J., Heil, M., May, J., White, L., Maddry, J. A., et al. (2007). High throughput drug screening for human immunodeficiency virus type 1 reactivating compounds. Assay and Drug Development Technologies, 5(2), 181-189.

Jordan, V. C., & O’Malley, B. W. (2007). Selective estrogen-receptor modulators and antihormonal resistance in breast cancer. Journal of Clinical Oncology, 25(36), 5815-5824.

Jung, C. G., Kim, H. J., Miron, V. E., Cook, S., Kennedy, T. E., Foster, C. A., et al. (2007). Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells. Glia, 55(16), 1656-1667.

Kanneganti, T. -., Lamkanfi, M., & Núñez, G. (2007). Intracellular NOD-like receptors in host defense and disease. Immunity, 27(4), 549-559.

Kawasumi, M., & Nghiem, P. (2007). Chemical genetics: Elucidating biological systems with small-molecule compounds. Journal of Investigative Dermatology, 127(7), 1577-1584.

Kenakin, T., & Domanico, P. (2007). Pharmacologists get a bigger and better tool box. Current Opinion in Pharmacology, 7(5), 505-506.

Kofoed, J., & Reymond, J. -. (2007). Identification of protease substrates by combinatorial profiling on TentaGel beads. Chemical Communications, (43), 4453-4455.

Kozarich, J. W. (2007). New LSD therapies unfolding. Chemistry and Biology, 14(9), 976-977.

Lazo, J. S., Brady, L. S., & Dingledine, R. (2007). Building a pharmacological lexicon: Small molecule discovery in academia. Molecular Pharmacology, 72(1), 1-7.

Martinon, F., Gaide, O., Pétrilli, V., Mayor, A., & Tschopp, J. (2007). NALP inflammasomes: A central role in innate immunity. Seminars in Immunopathology, 29(3), 213-229.

McDermott, M. F., & Tschopp, J. (2007). From inflammasomes to fevers, crystals and hypertension: How basic research explains inflammatory diseases. Trends in Molecular Medicine, 13(9), 381-388.

Meyer zu Heringdorf, D., & Jakobs, K. H. (2007). Lysophospholipid receptors: Signalling, pharmacology and regulation by lysophospholipid metabolism. Biochimica Et Biophysica Acta – Biomembranes, 1768(4), 923-940.

Miao, E. A., Andersen-Nissen, E., Warren, S. E., & Aderem, A. (2007). TLR5 and ipaf: Dual sensors of bacterial flagellin in the innate immune system. Seminars in Immunopathology, 29(3), 275-288.

Mitchell, M. O. (2007). Antibacterial agents against methicillin-resistant staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Anti-Infective Agents in Medicinal Chemistry, 6(4), 243-247.

Mitra, P., Payne, S. G., Milstien, S., & Spiegel, S. (2007). A rapid and sensitive method to measure secretion of sphingosine-1-phosphate

Muller, C. D., Peluso, J., Tabaka-Moreira, H., Taquet, N., Dumont, S., & Reimund, J. -. (2007). Can flow cytometry play a part in cell based high-content screening? Cytometry Part A, 71(11), 901-904.

Murph, M., & Mills, G. B. (2007). Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression. Expert Reviews in Molecular Medicine, 9(28), 1-18.

Murphy, E., & Steenbergen, C. (2007). Gender-based differences in mechanisms of protection in myocardial ischemia-reperfusion injury. Cardiovascular Research, 75(3), 478-486.

Myat, L. O., Thangada, S., Wu, M. -., Liu, C. H., Macdonald, T. L., Lynch, K. R., et al. (2007). Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. Journal of Biological Chemistry, 282(12), 9082-9089.

Nakamura, T., Yonesu, K., Mizuno, Y., Suzuki, C., Sakata, Y., Takuwa, Y., et al. (2007). Synthesis and SAR studies of a novel class of S1P1 receptor antagonists. Bioorganic and Medicinal Chemistry, 15(10), 3548-3564.

Narita, S. -., Goldblum, R. M., Watson, C. S., Brooks, E. G., Estes, D. M., Curran, E. M., et al. (2007). Environmental estrogens induce mast cell degranulation and enhance IgE-mediated release of allergic mediators. Environmental Health Perspectives, 115(1), 48-52.

Neilson, J. R., Zheng, G. X. Y., Burge, C. B., & Sharp, P. A. (2007). Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes and Development, 21(5), 578-589.

Nombela-Arrieta, C., Mempel, T. R., Soriano, S. F., Mazo, I., Wymann, M. P., Hirsch, E., et al. (2007). A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. Journal of Experimental Medicine, 204(3), 497-510.

Okamoto, I., Yamasaki, R., Sawamura, M., Kato, T., Nagayama, N., Takeya, T., et al. (2007). Redox-induced conformational alteration of N,N-diarylamides. Organic Letters, 9(26), 5545-5547.

Omori, K., Shikata, Y., Sarai, K., Watanabe, N., Wada, J., Goda, N., et al. (2007). Edaravone mimics sphingosine-1-phosphate-induced endothelial barrier enhancement in human microvascular endothelial cells. American Journal of Physiology – Cell Physiology, 293(5), C1523-C1531.

Onuoha, S. C., Mukund, S. R., Coulstock, E. T., Sengerovà, B., Shaw, J., McLaughlin, S. H., et al. (2007). Mechanistic studies on Hsp90 inhibition by ansamycin derivatives. Journal of Molecular Biology, 372(2), 287-297.

Oprea, T. I., Tropsha, A., Faulon, J. -., & Rintoul, M. D. (2007). Systems chemical biology. Nature Chemical Biology, 3(8), 447-450.

Oprea, T. I., Allu, T. K., Fara, D. C., Rad, R. F., Ostopovici, L., & Bologa, C. G. (2007). Lead-like, drug-like or “pub-like”: How different are they? Journal of Computer-Aided Molecular Design, 21(1-3), 113-119.

Osak, B., & Fitzgerald, L. R. (2007). A β-lactamase reporter assay for monitoring the activation of the smoothened pathway. Assay and Drug Development Technologies, 5(6), 785-792.

Osinde, M., Mullershausen, F., & Dev, K. K. (2007). Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors. Neuropharmacology, 52(5), 1210-1218.

Oskeritzian, C. A., Milstien, S., & Spiegel, S. (2007). Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis. Pharmacology and Therapeutics, 115(3), 390-399.

Pabst, R. (2007). Plasticity and heterogeneity of lymphoid organs. what are the criteria to call a lymphoid organ primary, secondary or tertiary? Immunology Letters, 112(1), 1-8.

Pedra, J. H. F., Sutterwala, F. S., Sukumaran, B., Ogura, Y., Qian, F., Montgomery, R. R., et al. (2007). ASC/PYCARD and caspase-1 regulate the IL-18/IFN-γ axis during anaplasma phagocytophilum infection. Journal of Immunology, 179(7), 4783-4791.

Peters, S. L., & Alewijnse, A. E. (2007). Sphingosine-1-phosphate signaling in the cardiovascular system. Current Opinion in Pharmacology, 7(2), 186-192.

Petrie, H. T., & Zúñiga-Pflücker, J. C. (2007). Zoned out: Functional mapping of stromal signaling microenvironments in the thymus

Pétrilli, V., Dostert, C., Muruve, D. A., & Tschopp, J. (2007). The inflammasome: A danger sensing complex triggering innate immunity. Current Opinion in Immunology, 19(6), 615-622.

Pétrilli, V., Papin, S., Dostert, C., Mayor, A., Martinon, F., & Tschopp, J. (2007). Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death and Differentiation, 14(9), 1583-1589.

Pietras, R. J., & Márquez-Garbán, D. C. (2007). Membrane-associated estrogen receptor signaling pathways in human cancers. Clinical Cancer Research, 13(16), 4672-4676.

Pohjala, L., Hakkola, J., & Vuorela, P. (2007). Predictive value of cellular methods in toxicological evaluation of lead candidates: An insight to hepatotoxicity. Drug Discovery Today: Technologies, 4(3-4), e97-e101.

Reddy, A. S., Pati, S. P., Kumar, P. P., Pradeep, H. N., & Sastry, G. N. (2007). Virtual screening in drug discovery – A computational perspective. Current Protein and Peptide Science, 8(4), 329-351.

Regitz-Zagrosek, V., Wintermantel, T. M., & Schubert, C. (2007). Estrogens and SERMs in coronary heart disease. Current Opinion in Pharmacology, 7(2), 130-139.

Rodrigues, D. J., Lyons, R., Laflin, P., Pointon, W., & Kammonen, J. (2007). A three-stage experimental strategy to evaluate and validate an interplate IC50 format. Assay and Drug Development Technologies, 5(6), 805-813.

Sakurai, A., Kurata, A., Onishi, Y., Hirano, H., & Ishikawa, T. (2007). Prediction of drug-induced intrahepatic cholestasis: In vitro screening and QSAR analysis of drugs inhibiting the human bile salt export pump. Expert Opinion on Drug Safety, 6(1), 71-86.

Sankala, H. M., Hait, N. C., Paugh, S. W., Shida, D., Lépine, S., Elmore, L. W., et al. (2007). Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. Cancer Research, 67(21), 10466-10474.

Schuffenhauer, A., Ertl, P., Roggo, S., Wetzel, S., Koch, M. A., & Waldmann, H. (2007). The scaffold tree – visualization of the scaffold universe by hierarchical scaffold classification. Journal of Chemical Information and Modeling, 47(1), 47-58.

Schwab, S. R., & Cyster, J. G. (2007). Finding a way out: Lymphocyte egress from lymphoid organs. Nature Immunology, 8(12), 1295-1301.

Scior, T., Bernard, P., Medina-Franco, J. L., & Maggiora, G. M. (2007). Large compound databases for structure-activity relationships studies in drug discovery. Mini-Reviews in Medicinal Chemistry, 7(8), 851-860.

Scott, P. -., Tremblay, A., Brochu, M., & St-Louis, J. (2007). Vasorelaxant action of 17β-estradiol in rat uterine arteries: Role of nitric oxide synthases and estrogen receptors. American Journal of Physiology – Heart and Circulatory Physiology, 293(6), H3713-H3719.

Seshadri, S., Duncan, M. D., Hart, J. M., Gavrilin, M. A., & Wewers, M. D. (2007). Pyrin levels in human monocytes and monocyte-derived macrophages regulate IL-1β processing and release. Journal of Immunology, 179(2), 1274-1281.

Shah, J. Z., & Bt Salim, N. (2007). A soft hierarchical algorithm for the clustering of multiple bioactive chemical compounds. Paper presented at the , 4414 LNBI 140-153.

Sidransky, E., LaMarca, M. E., & Ginns, E. I. (2007). Therapy for gaucher disease: Don’t stop thinking about tomorrow. Molecular Genetics and Metabolism, 90(2), 122-125.

Skoura, A., Sanchez, T., Claffey, K., Mandala, S. M., Proia, R. L., & Hla, T. (2007). Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. Journal of Clinical Investigation, 117(9), 2506-2516.

Southan, C., Várkonyi, P., & Muresan, S. (2007). Complementarity between public and commercial databases: New opportunities in medicinal chemistry informatics. Current Topics in Medicinal Chemistry, 7(15), 1502-1508.

Spiegel, S., & Milstien, S. (2007). Functions of the multifaceted family of sphingosine kinases and some close relatives. Journal of Biological Chemistry, 282(4), 2125-2129.

Spritz, R. A. (2007). The genetics of generalized vitiligo and associated autoimmune diseases. Pigment Cell Research, 20(4), 271-278.

Stehlik, C., & Dorfleutner, A. (2007). COPs and POPs: Modulators of inflammasome activity. Journal of Immunology, 179(12), 7993-7998.

Stein, V., Sielaff, I., Johnsson, K., & Hollfelder, F. (2007). A covalent chemical genotype-phenotype linkage for in vitro protein evolution. ChemBioChem, 8(18), 2191-2194.

Taussig, M. J., Stoevesandt, O., Borrebaeck, C. A. K., Bradbury, A. R., Cahill, D., Cambillau, C., et al. (2007). ProteomeBinders: Planning a european resource of affinity reagents for analysis of the human proteome. Nature Methods, 4(1), 13-17.

Tierno, M. B., Johnston, P. A., Foster, C., Skoko, J. J., Shinde, S. N., Shun, T. Y., et al. (2007). Development and optimization of high-throughput in vitro protein phosphatase screening assays. Nature Protocols, 2(5), 1134-1144.

Tikhonova, I. G., Chi, S. S., Neumann, S., Thomas, C. J., Raaka, B. M., Costanzi, S., et al. (2007). Bidirectional, iterative approach to the structural delineation of the functional “chemoprint” in GPR40 for agonist recognition. Journal of Medicinal Chemistry, 50(13), 2981-2989.

Vasudevan, N., & Pfaff, D. W. (2007). Membrane-initiated actions of estrogens in neuroendocrinology: Emerging principles. Endocrine Reviews, 28(1), 1-19.

Wallqvist, A., Huang, R., & Covell, D. G. (2007). Chemoinformatic analysis of NCI preclinical tumor data: Evaluating compound efficacy from mouse xenograft data, NCI-60 screening data, and compound descriptors. Journal of Chemical Information and Modeling, 47(4), 1414-1427.

Walzer, T., Chiossone, L., Chaix, J., Calver, A., Carozzo, C., Garrigue-Antar, L., et al. (2007). Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor. Nature Immunology, 8(12), 1337-1344.

Weiss, D. S., Henry, T., & Monack, D. M. (2007). Francisella tularensis: Activation of the inflammasome

Wells, J. A., & McClendon, C. L. (2007). Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature, 450(7172), 1001-1009.

Wetzel, S., Schuffenhauer, A., Roggo, S., Ertl, P., & Waldmann, H. (2007). Cheminformatic analysis of natural products and their chemical space. Chimia, 61(6), 355-360.

Winzell, M. S., & Ahrén, B. (2007). G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes. Pharmacology and Therapeutics, 116(3), 437-448.

Wu, G. S. (2007). Role of mitogen-activated protein kinase phosphatases (MKPs) in cancer. Cancer and Metastasis Reviews, 26(3-4), 579-585.

Yu, J. -., Fernandes-Alnemri, T., Datta, P., Wu, J., Juliana, C., Solorzano, L., et al. (2007). Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants. Molecular Cell, 28(2), 214-227.

Zhang, Z., & Schluesener, H. J. (2007). FTY720: A most promising immunosuppressant modulating immune cell functions. Mini-Reviews in Medicinal Chemistry, 7(8), 845-850.

Zhang, Z., Wang, P., Ding, N., Song, G., & Li, Y. (2007). Total synthesis of cleistetroside-2, partially acetylated dodecanyl tetrarhamnoside derivative isolated from cleistopholis patens and cleistopholis glauca. Carbohydrate Research, 342(9), 1159-1168.

Zhao, Y., He, D., Zhao, J., Wang, L., Leff, A. R., Spannhake, E. W., et al. (2007). Lysophosphatidic acid induces interleukin-13 (IL-13) receptor α2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells. Journal of Biological Chemistry, 282(14), 10172-10179.

Zhao, Z., Xiao, Y., Elson, P., Tan, H., Plummer, S. J., Berk, M., et al. (2007). Plasma lysophosphatidylcholine levels: Potential biomarkers for colorectal cancer. Journal of Clinical Oncology, 25(19), 2696-2701.