The Technology Development Initiatives began with the Molecular Libraries Pilot Phase and included Chemical Diversity, Assay Development, Cheminformatics, Instrumentation, and Predictive ADME/Toxicology. Of these five original initiatives, three will continue into the Production Phase of Molecular Libraries:
Assay Development supports the development of a continuously evolving stream of outstanding assays that can be miniaturized, automated and further used within the Molecular Libraries Probe Production Centers Network (MLPCN) for screening, disseminating information about small molecule-target interactions, and discovering novel molecular probes. Another aim of this effort is to enable the design of pharmacologic tools to explore cellular and physiological functions.
Chemical Diversity supports the development of new and diverse chemical libraries for screening in the MLSCN centers, as well as new methods for producing, isolating, characterizing, and modifying natural products.
Instrumentation supports the development of new instrumentation and devices for high-throughput screening. Topics currently supported include miniaturization and novel methods of detection of chemical/target interactions.
For the benefit of the biomedical research community, the Technology Development Initiatives were strategically designed to provide a set of novel technologies and innovative resources for elucidating the behavior of small molecule modulators, develop new and diverse chemical libraries for screening by the MLSCN Centers, stimulate the development of assays that could be automated and used within the MLSCN, discover creative and successful methods as well as instruments for use in high-throughput screening, and to support the development of further means of predicting Absorption, Distribution, Metabolism, Excretion (ADME) and toxicology novel molecules.
Points of Contact
For further information about each of the Technology Development Initiatives, contact:
Mark Scheideler, Ph.D.
Program Director, Molecular Libraries
Technology Development, NINDS
National Institutes of Health
6001 Executive Blvd., Room 2107
Rockville, MD 20852 (Express Mail)
Bethesda, MD 20892-9527 (Regular Mail)
Telephone: (301) 496-1779
Fax: (301) 402-1501
John M. Schwab, Ph.D.
Division of Pharmacology, Physiology, and Biological Chemistry
National Institute of General Medical Sciences
45 Center Drive, Room 2As.43A MSC 6200
Bethesda, MD 20892-6200
Telephone: (301) 594-3827
FAX: (301) 480-2802
Division of Extramural Research
National Human Genome Research Institute
5635 Fishers Lane
Suite 4076, MSC 9305
Rockville, MD 20892-9305 (regular mail)
Rockville, MD 20852 (courier mail)
Telephone: (301) 496-7531
Brenda Korte, Ph.D
National Institute of Biomedical Imaging and Bioengineering
Co-Leader, MLI Instrumentation Project Team