Screening Centers
Center Descriptions
The Molecular Libraries Screening Centers Network (MLSCN) consists of 10 centers with a diverse set of screening platform technologies that include ultraHTS, cell based imaging, and flow cytometry. The ten screening centers are capable of running almost any biochemical or cell-based assays. Assay formats that can be implemented in the network include cell-based, biochemical, protein-protein interactions and some model organisms. At this time, whole organism assay capability is being developed within the network and is currently available to a limited extent and only at very low throughput. The network can implement biological assays using a variety of detection systems that include: luminescence, fluorescence, FLIPR, FRET, SPA, absorbance, ELISA, microscopy-based imaging, and small molecule microarray.
A brief summary of each of the Center’s capabilities can be found below.
The below chart contains information about the awarded MLSCN principal investigators, their relative institutional affiliation, the name of their Molecular Libraries Screening Center, and links to their proposed research project and Center Web site.
MLSCN Centers
| PI Name | Institution Name | Title |
|---|---|---|
| Austin, Chris | NHGRI | NIH Chemical Genomics Center (NCGC) Additional Information |
| Diamond, Scott | University Of Pennsylvania | The Penn Center for Molecular Discovery Additional Information Abstract (from CRISP) |
| Dingledine, Raymond | Emory University | Emory Chemistry-Biology Center in the MLSCN Abstract (from CRISP) |
| Lazo, John | University Of Pittsburgh At Pittsburgh | University of Pittsburgh Molecular Libraries Screening Center Additional Information Abstract (from CRISP) |
| Piazza, Gary | Southern Research Institute | Southern Research Molecular Libraries Screening Center Abstract (from CRISP) |
| Reed, John | The Burnham Institute | San Diego Center for Chemical Genomics Abstract (from CRISP) |
| Rosen, Hugh | The Scripps Research Institute | Scripps Research Institute Molecular Screening Center Abstract (from CRISP) |
| Rothman, James | Columbia University Medical Center | MLSCN Center at Columbia University Abstract (from CRISP) |
| Sklar, Larry | University Of New Mexico Albuquerque | New Mexico Molecular Libraries Screening Center Additional Information Abstract (from CRISP) |
| Weaver, C. David | Vanderbilt University | Vanderbilt Screening Center for GPCRs, Ion Channels, and Transporters Additional Information Abstract (from CRISP) |
